Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

Autor: Chegou, NN, Sutherland, JS, Malherbe, S, Crampin, AC, Corstjens, PL, Geluk, A, Mayanja-Kizza, H, Loxton, AG, van der Spuy, G, Stanley, K, Kotzé, LA, van der Vyver, M, Rosenkrands, I, Kidd, M, van Helden, PD, Dockrell, HM, Ottenhoff, TH, Kaufmann, SH, Walzl, G, AE-TBC consortium, COLLABORATORS, Kriel, M, Kriel, B, Awoniyi, DO, Maasdorp, E, Owolabi, O, Sillah, A, Mendy, J, Gindeh, A, Donkor, S, Togun, T, Ota, M, Simukonda, F, Amberbir, A, Chilongo, F, Houben, R, Kassa, D, Gebrezgeabher, A, Mesfin, G, Belay, Y, Gebremichael, G, Alemayehu, Y, Amutenya, FN, Nelongo, JN, Monye, L, Sheehama, JA, Iipinge, S, Namuganga, AR, Muzanye, G, Nsereko, M, Peters, P, Howe, R, Mihret, A, Bekele, Y, Tessema, B, Yamuah, L, Franken, KL, Fat, EM, de Dood, CJ, van der Ploeg-van Schip, JJ, Aagaard, C, Esterhuyse, MM, Cliff, JM

User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently needed at points of care in resource-limited settings. We investigated host biomarkers detected in serum samples obtained from adults with signs and symptoms suggestive o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4462c525078bdcd75d5f61a9ee0c0820

Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis.

Autor: Jacobs R; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Awoniyi DO; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Baumann R; Lionex Diagnostics and Therapeutics, Braunschweig, Germany; Medical Faculty, Institute for Translational Medicine, Medical School Hamburg (MSH) - Medical University, Hamburg, Germany; Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany., Stanley K; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., McAnda S; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Kaempfer S; Lionex Diagnostics and Therapeutics, Braunschweig, Germany., Malherbe ST; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Singh M; Lionex Diagnostics and Therapeutics, Braunschweig, Germany., Walzl G; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Chegou NN; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: novel@sun.ac.za.

Publikováno v: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2022 Mar; Vol. 133, pp. 102169. Date of Electronic Publication: 2022 Jan 31.

Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease.

Autor: Awoniyi DO; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, Cape Town, South Africa., Teuchert A; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, Cape Town, South Africa., Sutherland JS; Medical Research Council Unit, Fajara, Gambia., Mayanja-Kizza H; Department of Medicine, Makerere University, Kampala, Uganda., Howe R; Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Mihret A; Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Loxton AG; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, Cape Town, South Africa., Sheehama J; University of Namibia, Faculty of Health Sciences, School of Medicine, Namibia., Kassa D; Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia., Crampin AC; Karonga Prevention Study, Chilumba, Malawi; London School of Hygiene and Tropical Medicine, London, UK., Dockrell HM; London School of Hygiene and Tropical Medicine, London, UK., Kidd M; Centre for Statistical Analysis, Stellenbosch University, South Africa., Rosenkrands I; Statens Serum Institut, Copenhagen, Denmark., Geluk A; Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands., Ottenhoff TH; Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands., Corstjens PL; Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands., Chegou NN; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, Cape Town, South Africa., Walzl G; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, Cape Town, South Africa. Electronic address: gwalzl@sun.ac.za.

Publikováno v: The Journal of infection [J Infect] 2016 Sep; Vol. 73 (3), pp. 219-30. Date of Electronic Publication: 2016 Jun 14.