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mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern.

Autor: Goel RR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Painter MM; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Apostolidis SA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs.; Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Mathew D; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Meng W; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Rosenfeld AM; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lundgreen KA; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Reynaldi A; Kirby Institute, University of New South Wales, Sydney, Australia., Khoury DS; Kirby Institute, University of New South Wales, Sydney, Australia., Pattekar A; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Gouma S; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kuri-Cervantes L; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hicks P; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Dysinger S; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hicks A; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Sharma H; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Herring S; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Korte S; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Baxter AE; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Oldridge DA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Giles JR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Weirick ME; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., McAllister CM; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Awofolaju M; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tanenbaum N; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Drapeau EM; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Dougherty J; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Long S; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., D'Andrea K; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hamilton JT; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs.; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., McLaughlin M; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Williams JC; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Adamski S; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Kuthuru O; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Frank I; Division of Infectious Disease, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Betts MR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Vella LA; Division of Infectious Disease, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA., Hensley SE; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Davenport MP; Kirby Institute, University of New South Wales, Sydney, Australia., Bates P; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Luning Prak ET; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Greenplate AR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs., Wherry EJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAs.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Aug 23. Date of Electronic Publication: 2021 Aug 23.