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First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

Autor: RTS,S Clinical Trials Partnership, Agnandji, Selidji Todagbe, Lell, Bertrand, Soulanoudjingar, Solange Solmeheim, Fernandes, José Francisco, Abossolo, Béatrice Peggy, Conzelmann, Cornelia, Methogo, Barbara Gaelle Nfono Ondo, Doucka, Yannick, Flamen, Arnaud, Mordmüller, Benjamin, Issifou, Saadou, Kremsner, Peter Gottfried, Sacarlal, Jahit, Aide, Pedro, Lanaspa, Miguel, Aponte, John J, Nhamuave, Arlindo, Quelhas, Diana, Bassat, Quique, Mandjate, Sofia, Macete, Eusébio, Alonso, Pedro, Abdulla, Salim, Salim, Nahya, Juma, Omar, Shomari, Mwanajaa, Shubis, Kafuruki, Machera, Francisca, Hamad, Ali Said, Minja, Rose, Mtoro, Ali, Sykes, Alma, Ahmed, Saumu, Urassa, Alwisa Martin, Ali, Ali Mohammed, Mwangoka, Grace, Tanner, Marcel, Tinto, Halidou, D'Alessandro, Umberto, Sorgho, Hermann, Valea, Innocent, Tahita, Marc Christian, Kaboré, William, Ouédraogo, Sayouba, Sandrine, Yara, Guiguemdé, Robert Tinga, Ouédraogo, Jean Bosco, Hamel, Mary J, Kariuki, Simon, Odero, Chris, Oneko, Martina, Otieno, Kephas, Awino, Norbert, Omoto, Jackton, Williamson, John, Muturi-Kioi, Vincent, Laserson, Kayla F, Slutsker, Laurence, Otieno, Walter, Otieno, Lucas, Nekoye, Otsyula, Gondi, Stacey, Otieno, Allan, Ogutu, Bernhards, Wasuna, Ruth, Owira, Victorine, Jones, David, Onyango, Agnes Akoth, Njuguna, Patricia, Chilengi, Roma, Akoo, Pauline, Kerubo, Christine, Gitaka, Jesse, Maingi, Charity, Lang, Trudie, Olotu, Ally, Tsofa, Benjamin, Bejon, Philip, Peshu, Norbert, Marsh, Kevin, Owusu-Agyei, Seth, Asante, Kwaku Poku, Osei-Kwakye, Kingsley, Boahen, Owusu, Ayamba, Samuel, Kayan, Kingsley, Owusu-Ofori, Ruth, Dosoo, David, Asante, Isaac, Adjei, George, Chandramohan, Daniel, Greenwood, Brian, Lusingu, John, Gesase, Samwel, Malabeja, Anangisye, Abdul, Omari, Kilavo, Hassan, Mahende, Coline, Liheluka, Edwin, Lemnge, Martha, Theander, Thor, Drakeley, Chris, Ansong, Daniel, Agbenyega, Tsiri, Adjei, Samuel, Boateng, Harry Owusu, Rettig, Theresa, Bawa, John, Sylverken, Justice, Sambian, David, Agyekum, Alex, Owusu, Larko, Martinson, Francis, Hoffman, Irving, Mvalo, Tisungane, Kamthunzi, Portia, Nkomo, Ruthendo, Msika, Albans, Jumbe, Allan, Chome, Nelecy, Nyakuipa, Dalitso, Chintedza, Joseph, Ballou, W Ripley, Bruls, Myriam, Cohen, Joe, Guerra, Yolanda, Jongert, Erik, Lapierre, Didier, Leach, Amanda, Lievens, Marc, Ofori-Anyinam, Opokua, Vekemans, Johan, Carter, Terrell, Leboulleux, Didier, Loucq, Christian, Radford, Afiya, Savarese, Barbara, Schellenberg, David, Sillman, Marla, Vansadia, Preeti

BACKGROUND: An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries. METHODS: From March 2009 through January 2011, we enrolled 15,460 children in two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3007e93080adaf923eb3795c29a66392
https://researchonline.lshtm.ac.uk/id/eprint/39130/1/nejmoa1102287.pdf

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.

Autor: Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, Adegnika AA, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Machevo S, Acacio S, Bulo H, Sigauque B, Macete E, Alonso P, Abdulla S, Salim N, Minja R, Mpina M, Ahmed S, Ali AM, Mtoro AT, Hamad AS, Mutani P, Tanner M, Tinto H, D'Alessandro U, Sorgho H, Valea I, Bihoun B, Guiraud I, Kaboré B, Sombié O, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Oneko M, Odero C, Otieno K, Awino N, McMorrow M, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Otsyula N, Gondi S, Otieno A, Owira V, Oguk E, Odongo G, Woods JB, Ogutu B, Njuguna P, Chilengi R, Akoo P, Kerubo C, Maingi C, Lang T, Olotu A, Bejon P, Marsh K, Mwambingu G, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Dosoo D, Asante I, Adjei G, Kwara E, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Mahende C, Liheluka E, Malle L, Lemnge M, Theander TG, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Sarfo A, Agyekum A, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Tembo T, Tegha G, Tsidya M, Kilembe J, Chawinga C, Ballou WR, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Olivier A, Vekemans J, Carter T, Kaslow D, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P

Publikováno v: The New England journal of medicine [N Engl J Med] 2012 Dec 13; Vol. 367 (24), pp. 2284-95. Date of Electronic Publication: 2012 Nov 09.