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Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

Autor: Agnandji, ST, Lell, B, Fernandes, JF, Abossolo, BP, Kabwende, AL, Adegnika, AA, Mordmueller, B, Issifou, S, Kremsner, PG, Loembe, MM, Sacarlal, J, Aide, P, Madrid, L, Lanaspa, M, Mandjate, S, Aponte, JJ, Bulo, H, Nhama, A, Macete, E, Alonso, P, Abdulla, S, Salim, N, Mtoro, AT, Mutani, P, Tanner, M, Mavere, C, Mwangoka, G, Lweno, O, Juma, OA, Shekalaghe, S, Tinto, H, D'Alessandro, U, Sorgho, H, Valea, I, Ouedraogo, JB, Lompo, P, Diallo, S, Traore, O, Bassole, A, Dao, E, Hamel, MJ, Kariuki, S, Oneko, M, Odero, C, Otieno, K, Awino, N, Muturi-Kioi, V, Omoto, J, Laserson, KF, Slutsker, L, Otieno, W, Otieno, L, Otsyula, N, Gondi, S, Otieno, A, Ogutu, B, Ochola, J, Onyango, I, Oyieko, J, Njuguna, P, Chilengi, R, Akoo, P, Kerubo, C, Maingi, C, Olotu, A, Bejon, P, Marsh, K, Mwabingu, G, Gitaka, J, Owusu-Agyei, S, Asante, KP, Boahen, O, Dosoo, D, Adjei, G, Adeniji, E, Yawson, AK, Kayan, K, Chandramohan, D, Greenwood, B, Lusingu, J, Gesase, S, Malabeja, A, Abdul, O, Mahende, C, Liheluka, E, Lemnge, M, Theander, TG, Drakeley, C, Mbwana, J, Ansong, D, Agbenyega, T, Adjei, S, Boateng, HO, Rettig, T, Bawa, J, Sylverken, J, Sambian, D, Sarfo, A, Agyekum, A, Martinson, F, Hoffman, I, Mvalo, T, Kamthunzi, P, Nkomo, R, Tembo, T, Tsidya, GTM, Kilembe, J, Chawinga, C, Ballou, WR, Cohen, J, Guerra, Y, Jongert, E, Lapierre, D, Leach, A, Lievens, M, Ofori-Anyinam, O, Olivier, A, Vekemans, J, Kaslow, D, Leboulleux, D, Savarese, B, Schellenberg, D, Partnership, RTSSCT

Publikováno v: PLoS Medicine
PLoS Medicine, Vol 11, Iss 7, p e1001685 (2014)

Mary Hamel and colleagues in the RTS,S Clinical Trials Partnership report updated safety and efficacy results from an ongoing Phase 3 trial, including calculations of vaccine impact (malaria cases prevented). Please see later in the article for the E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6236e8cf4d7a1ce20ddc0ba7bb18b40
http://europepmc.org/articles/PMC4114488

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Akademický článek

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Vybrat výsledek číslo 3 3

Akademický článek

Vaccines and Monoclonal Antibodies as Alternative Strategies to Antibiotics to Fight Antimicrobial Resistance.

Autor: La Guidara, Chiara^1,2 (AUTHOR), Adamo, Roberto³ (AUTHOR), Sala, Claudia⁴ (AUTHOR), Micoli, Francesca⁵ (AUTHOR) francesca.x.micoli@gsk.com

Publikováno v: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 10, p5487. 21p.

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Vybrat výsledek číslo 4 4

Akademický článek

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial.

Autor: Samuels AM; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA. iyp2@cdc.gov.; Centers for Disease Control and Prevention, Kisian Campus, Off Busia Road, P O Box 1578, Kisumu, 40100, Kenya. iyp2@cdc.gov., Awino N; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Odongo W; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Abong'o B; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Gimnig J; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Otieno K; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Shi YP; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Were V; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Allen DR; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Were F; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Sang T; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Obor D; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Williamson J; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Hamel MJ; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Patrick Kachur S; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Slutsker L; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Lindblade KA; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Kariuki S; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Desai M; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.

Publikováno v: Malaria journal [Malar J] 2017 Jun 07; Vol. 16 (1), pp. 240. Date of Electronic Publication: 2017 Jun 07.

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Vybrat výsledek číslo 5 5

Akademický článek

Safety and immunogenicity of RTS,S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial.

Autor: Otieno L; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya. Electronic address: Lucas.Tina@usamru-k.org., Oneko M; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Otieno W; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Abuodha J; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Owino E; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Odero C; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Mendoza YG; GlaxoSmithKline Vaccines, Wavre, Belgium., Andagalu B; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Awino N; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Ivinson K; PATH Malaria Vaccine Initiative, Washington, DC, USA., Heerwegh D; GlaxoSmithKline Vaccines, Wavre, Belgium., Otsyula N; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Oziemkowska M; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Usuf EA; GlaxoSmithKline Vaccines, Wavre, Belgium., Otieno A; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Otieno K; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Leboulleux D; PATH Malaria Vaccine Initiative, Washington, DC, USA., Leach A; GlaxoSmithKline Vaccines, Wavre, Belgium., Oyieko J; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Slutsker L; Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Lievens M; GlaxoSmithKline Vaccines, Wavre, Belgium., Cowden J; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Lapierre D; GlaxoSmithKline Vaccines, Wavre, Belgium., Kariuki S; KEMRI/Centers for Disease Control and Prevention Research and Public Health Collaboration, Kisumu, Kenya., Ogutu B; Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kombewa, Kenya., Vekemans J; GlaxoSmithKline Vaccines, Wavre, Belgium., Hamel MJ; Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Publikováno v: The Lancet. Infectious diseases [Lancet Infect Dis] 2016 Oct; Vol. 16 (10), pp. 1134-1144. Date of Electronic Publication: 2016 Jul 07.

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Vybrat výsledek číslo 6 6

Akademický článek

Community perceptions of mass screening and treatment for malaria in Siaya County, western Kenya.

Autor: Shuford K; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. kvshuford@gmail.com., Were F; Kenya Medical Research Institute (KEMRI), Kisian, Kenya. fachieng@kemricdc.org., Awino N; Kenya Medical Research Institute (KEMRI), Kisian, Kenya. nobatisland@gmail.com., Samuels A; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. amsamuels@cdc.gov., Ouma P; Kenya Medical Research Institute (KEMRI), Kisian, Kenya. pouma@kemricdc.org., Kariuki S; Kenya Medical Research Institute (KEMRI), Kisian, Kenya. skariuki@kemricdc.org., Desai M; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. mdesai@cdc.gov., Allen DR; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. drothallen@cdc.gov.

Publikováno v: Malaria journal [Malar J] 2016 Feb 06; Vol. 15, pp. 71. Date of Electronic Publication: 2016 Feb 06.

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Vybrat výsledek číslo 7 7

Akademický článek

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.

Autor: Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, Adegnika AA, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Machevo S, Acacio S, Bulo H, Sigauque B, Macete E, Alonso P, Abdulla S, Salim N, Minja R, Mpina M, Ahmed S, Ali AM, Mtoro AT, Hamad AS, Mutani P, Tanner M, Tinto H, D'Alessandro U, Sorgho H, Valea I, Bihoun B, Guiraud I, Kaboré B, Sombié O, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Oneko M, Odero C, Otieno K, Awino N, McMorrow M, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Otsyula N, Gondi S, Otieno A, Owira V, Oguk E, Odongo G, Woods JB, Ogutu B, Njuguna P, Chilengi R, Akoo P, Kerubo C, Maingi C, Lang T, Olotu A, Bejon P, Marsh K, Mwambingu G, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Dosoo D, Asante I, Adjei G, Kwara E, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Mahende C, Liheluka E, Malle L, Lemnge M, Theander TG, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Sarfo A, Agyekum A, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Tembo T, Tegha G, Tsidya M, Kilembe J, Chawinga C, Ballou WR, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Olivier A, Vekemans J, Carter T, Kaslow D, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P

Publikováno v: The New England journal of medicine [N Engl J Med] 2012 Dec 13; Vol. 367 (24), pp. 2284-95. Date of Electronic Publication: 2012 Nov 09.

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Vybrat výsledek číslo 8 8

Akademický článek

Malaria Therapeutic Paradigm: An Evolution Towards Commercial Drug Delivery Technology.

Autor: Kumari, Alka, Bajwa, Neha

Publikováno v: Current Treatment Options in Infectious Diseases; Dec2024, Vol. 16 Issue 4, p89-104, 16p

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Vybrat výsledek číslo 9 9

Akademický článek

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.

Autor: Agnandji ST; Albert Schweitzer Hospital, Lambarene, Gabon., Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, Conzelmann C, Methogo BG, Doucka Y, Flamen A, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Nhamuave A, Quelhas D, Bassat Q, Mandjate S, Macete E, Alonso P, Abdulla S, Salim N, Juma O, Shomari M, Shubis K, Machera F, Hamad AS, Minja R, Mtoro A, Sykes A, Ahmed S, Urassa AM, Ali AM, Mwangoka G, Tanner M, Tinto H, D'Alessandro U, Sorgho H, Valea I, Tahita MC, Kaboré W, Ouédraogo S, Sandrine Y, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Odero C, Oneko M, Otieno K, Awino N, Omoto J, Williamson J, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Nekoye O, Gondi S, Otieno A, Ogutu B, Wasuna R, Owira V, Jones D, Onyango AA, Njuguna P, Chilengi R, Akoo P, Kerubo C, Gitaka J, Maingi C, Lang T, Olotu A, Tsofa B, Bejon P, Peshu N, Marsh K, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Ayamba S, Kayan K, Owusu-Ofori R, Dosoo D, Asante I, Adjei G, Adjei G, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Kilavo H, Mahende C, Liheluka E, Lemnge M, Theander T, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Agyekum A, Owusu L, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Msika A, Jumbe A, Chome N, Nyakuipa D, Chintedza J, Ballou WR, Bruls M, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Vekemans J, Carter T, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P

Publikováno v: The New England journal of medicine [N Engl J Med] 2011 Nov 17; Vol. 365 (20), pp. 1863-75. Date of Electronic Publication: 2011 Oct 18.

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Vybrat výsledek číslo 10 10

Akademický článek

Novel application of one-step pooled molecular testing and maximum likelihood approaches to estimate the prevalence of malaria parasitaemia among rapid diagnostic test negative samples in western Kenya.