Utility of urine and serum lateral flow assays to determine the prevalence and predictors of cryptococcal antigenemia in HIV‐positive outpatients beginning antiretroviral therapy in Mwanza, Tanzania

Autor: Kinanga A Magambo, Samuel E Kalluvya, Shikha W Kapoor, Jeremiah Seni, Awilly A Chofle, Daniel W Fitzgerald, Jennifer A Downs

Publikováno v: Journal of the International AIDS Society, Vol 17, Iss 1, Pp n/a-n/a (2014)

Background Detection of subclinical cryptococcal disease using cryptococcal antigen screening among HIV‐positive individuals presents a potential opportunity for prevention of both clinical disease and death if patients with detectable cryptococcal

Externí odkaz: https://doaj.org/article/a75d50ab0b9c4766a1338f3add802e44

AMBITION-cm : intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa : study protocol for a randomized controlled trial

Autor: Tariro Makadzange, John Changalucha, Rosie Burton, William W. Hope, Mooketsi Molefi, Miriam Haverkamp, Awilly A Chofle, Thomas S. Harrison, Chiratidzo E. Ndhlovu, Síle F. Molloy, John R. Perfect, Emili Letang, Joseph N Jarvis, Gregory P. Bisson, Graeme Meintjes, Samuel E. Kalluvya, Lukas Fenner, Tshepo B Leeme, Francesca Cainelli, Drew W. Goldberg, Nametso Lekwape

Publikováno v: Trials

Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f3f1117a8ac06616a18d77e12d121e
https://edoc.unibas.ch/37939/

Oesophageal Varices, Schistosomiasis, and Mortality among Patients Admitted with Haematemesis in Mwanza, Tanzania: A Prospective Cohort Study

Autor: Hyasinta Jaka, Jennifer A. Downs, Rodrick Kabangila, Luke R. Smart, Warren D. Johnson, Fiona M. Ewings, Daniel W. Fitzgerald, Mheta Koy, Humphrey D. Mazigo, Robert N. Peck, Awilly A Chofle

Publikováno v: BMC Infectious Diseases

BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common cause of hospital admissions worldwide. Aetiologies vary by sociodemographics and geography. Retrospective studies of endoscopies in much of Africa have documented oesophageal varices as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363babb37fe559d9993b56123eef03f9
http://digitallibrary.ihi.or.tz/2700/

Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis.

Autor: Stott KE; Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology, University of Liverpool, UK.; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi., Moyo M; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Malawi., Ahmadu A; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi., Kajanga C; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi., Gondwe E; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi., Chimang'anga W; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi., Chasweka M; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi., Leeme TB; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Molefi M; University of Botswana, Gaborone, Botswana., Chofle A; National Institute of Medical Research, Mwanza, Tanzania., Bidwell G; National Institute of Medical Research, Mwanza, Tanzania., Changalucha J; National Institute of Medical Research, Mwanza, Tanzania., Unsworth J; Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology, University of Liverpool, UK., Jimenez-Valverde A; Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology, University of Liverpool, UK., Lawrence DS; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Mwandumba HC; Malawi Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Lalloo DG; Liverpool School of Tropical Medicine, Liverpool, UK., Harrison TS; Institute of Infection and Immunity, St George's University Hospital, London, UK.; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Jarvis JN; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Hope W; Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology, University of Liverpool, UK., Märtson AG; Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology, University of Liverpool, UK.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2022 Dec 23; Vol. 78 (1), pp. 276-283.