Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Awen M. Gallimore"'
Autor:
Yuan Chen, Georgina H. Mason, D. Oliver Scourfield, Alexander Greenshields-Watson, Tracey A. Haigh, Andrew K. Sewell, Heather M. Long, Awen M. Gallimore, Pierre Rizkallah, Bruce J. MacLachlan, Andrew Godkin
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112827- (2023)
Summary: CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 disease. We demonstrate that the immunogenicity of SARS-CoV-2 pept
Externí odkaz:
https://doaj.org/article/89d593fdc3ac46c694db2226da7cae58
Autor:
Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore, Andrew Godkin
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn’s disease and pote
Externí odkaz:
https://doaj.org/article/865832664a054e5190d402ae3a6a6bd7
Autor:
Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://doaj.org/article/ac1881b0cc804226bb104e9cab830657
Autor:
Awen M. Gallimore, Andrew J. Godkin, Ann Ager, David A. Price, David Withers, Katherine K. Wynn, Kristin Ladell, Scott Cutting, Beatrice Ondondo, Sarah N. Lauder, Hayley Bridgeman, Kathryn Smart, Emma Jones, James P. Hindley
PDF file - 234K, S Figure 1 - Levels of Foxp3+ Tregs and T cell activation following various doses of DT treatment. S Figure 2 - Efficient depletion of Foxp3+ Tregs leads to T cell activation and proliferation. S Figure 3 - T cell accumulation in tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ff76f34f1a157e7f043f35839ba7dd
https://doi.org/10.1158/0008-5472.22394828
https://doi.org/10.1158/0008-5472.22394828
Autor:
Stephanie E A Burnell, Lorenzo Capitani, Bruce J MacLachlan, Georgina H Mason, Awen M Gallimore, Andrew Godkin
Publikováno v:
Immunotherapy advances. 2(1)
Despite three decades of research to its name and increasing interest in immunotherapies that target it, LAG-3 remains an elusive co-inhibitory receptor in comparison to the well-established PD-1 and CTLA-4. As such, LAG-3 targeting therapies have ye
Autor:
Maria Paula Longhi, Kate Wright, Sarah N Lauder, Mari A Nowell, Gareth W Jones, Andrew J Godkin, Simon A Jones, Awen M Gallimore
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e1000006 (2008)
Currently, our understanding of mechanisms underlying cell-mediated immunity and particularly of mechanisms that promote robust T cell memory to respiratory viruses is incomplete. Interleukin (IL)-6 has recently re-emerged as an important regulator o
Externí odkaz:
https://doaj.org/article/4f96dab2637f40e18eebf2f95d79e27a
Autor:
Sarah L Clarke, Gareth J Betts, Andrea Plant, Kate L Wright, Tariq M El-Shanawany, Richard Harrop, Jared Torkington, Brian I Rees, Geraint T Williams, Awen M Gallimore, Andrew J Godkin
Publikováno v:
PLoS ONE, Vol 1, p e129 (2006)
A wealth of evidence obtained using mouse models indicates that CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) maintain peripheral tolerance to self-antigens and also inhibit anti-tumor immune responses. To date there is limited information about CD
Externí odkaz:
https://doaj.org/article/4895a4b8551a4cf1b3dcf51118aa6cb2
Autor:
Alexander, Greenshields-Watson, Meriem, Attaf, Bruce J, MacLachlan, Thomas, Whalley, Cristina, Rius, Aaron, Wall, Angharad, Lloyd, Hywel, Hughes, Kathryn E, Strange, Georgina H, Mason, Andrea J, Schauenburg, Sarah L, Hulin-Curtis, James, Geary, Yuan, Chen, Sarah N, Lauder, Kathryn, Smart, Dhanasekaran, Vijaykrishna, Miguel L, Grau, Mikhail, Shugay, Robert, Andrews, Garry, Dolton, Pierre J, Rizkallah, Awen M, Gallimore, Andrew K, Sewell, Andrew J, Godkin, David K, Cole
Publikováno v:
Cell Reports
Summary T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usin
Autor:
Emily J, Colbeck, James P, Hindley, Kathryn, Smart, Emma, Jones, Anja, Bloom, Hayley, Bridgeman, Rhoanne C, McPherson, Darryl G, Turner, Kristin, Ladell, David A, Price, Richard A, O'Connor, Stephen M, Anderton, Andrew J, Godkin, Awen M, Gallimore
Publikováno v:
Oncotarget
Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises large
Autor:
Maria A, Stacey, Morgan, Marsden, Tu Anh, Pham N, Simon, Clare, Garry, Dolton, Gabrielle, Stack, Emma, Jones, Paul, Klenerman, Awen M, Gallimore, Philip R, Taylor, Robert J, Snelgrove, Trevor D, Lawley, Gordon, Dougan, Chris A, Benedict, Simon A, Jones, Gavin W G, Wilkinson, Ian R, Humphreys
Publikováno v:
Cell Host & Microbe
Summary During primary infection, murine cytomegalovirus (MCMV) spreads systemically, resulting in virus replication and pathology in multiple organs. This disseminated infection is ultimately controlled, but the underlying immune defense mechanisms