Synthesis and Characterization of Novel BMI1 Inhibitors Targeting Cellular Self-Renewal in Hepatocellular Carcinoma.

Autor: Bartucci M; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA., Hussein MS; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA.; Clinical and Chemical Pathology, National Research Centre, Cairo, Egypt., Huselid E; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA.; Graduate Program in Cellular and Molecular Pharmacology, Graduate School of Biomedical Sciences, Rutgers University, New Brunswick, NJ, 08901, USA., Flaherty K; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA., Patrizii M; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA.; Graduate Program in Cellular and Molecular Pharmacology, Graduate School of Biomedical Sciences, Rutgers University, New Brunswick, NJ, 08901, USA., Laddha SV; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA.; Graduate Program in Quantitative Biomedicine, Institute for Quantitative Biomedicine at Rutgers University, New Brunswick, NJ, 08901, USA., Kui C; Molecular Design and Synthesis Laboratory, Rutgers Translational Sciences, Rutgers University, Piscataway, NJ, 08854, USA.; Department of Medicinal Chemistry, EMSOP, Rutgers University, Piscataway, NJ, 08854, USA., Bigos RA; Molecular Design and Synthesis Laboratory, Rutgers Translational Sciences, Rutgers University, Piscataway, NJ, 08854, USA.; Department of Medicinal Chemistry, EMSOP, Rutgers University, Piscataway, NJ, 08854, USA., Gilleran JA; Molecular Design and Synthesis Laboratory, Rutgers Translational Sciences, Rutgers University, Piscataway, NJ, 08854, USA.; Department of Medicinal Chemistry, EMSOP, Rutgers University, Piscataway, NJ, 08854, USA., El Ansary MMS; Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt., Awad MAM; Clinical and Chemical Pathology, National Research Centre, Cairo, Egypt., Kimball SD; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA.; Molecular Design and Synthesis Laboratory, Rutgers Translational Sciences, Rutgers University, Piscataway, NJ, 08854, USA.; Department of Medicinal Chemistry, EMSOP, Rutgers University, Piscataway, NJ, 08854, USA., Augeri DJ; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA.; Molecular Design and Synthesis Laboratory, Rutgers Translational Sciences, Rutgers University, Piscataway, NJ, 08854, USA.; Department of Medicinal Chemistry, EMSOP, Rutgers University, Piscataway, NJ, 08854, USA., Sabaawy HE; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, 08901, USA. sabaawhe@cinj.rutgers.edu.; Graduate Program in Cellular and Molecular Pharmacology, Graduate School of Biomedical Sciences, Rutgers University, New Brunswick, NJ, 08901, USA. sabaawhe@cinj.rutgers.edu.; Department of Medicine, RBHS-Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA. sabaawhe@cinj.rutgers.edu.

Publikováno v: Targeted oncology [Target Oncol] 2017 Aug; Vol. 12 (4), pp. 449-462.