Defects in microvillus crosslinking sensitize to colitis and inflammatory bowel disease.

Autor: Mödl, Bernadette, Awad, Monira, Zwolanek, Daniela, Scharf, Irene, Schwertner, Katharina, Milovanovic, Danijela, Moser, Doris, Schmidt, Katy, Pjevac, Petra, Hausmann, Bela, Krauß, Dana, Mohr, Thomas, Svinka, Jasmin, Kenner, Lukas, Casanova, Emilio, Timelthaler, Gerald, Sibilia, Maria, Krieger, Sigurd, Eferl, Robert

Publikováno v: EMBO Reports; 10/9/2023, Vol. 24 Issue 10, p1-18, 18p

IDO1+ Paneth cells promote immune escape of colorectal cancer.

Autor: Pflügler, Sandra, Svinka, Jasmin, Scharf, Irene, Crncec, Ilija, Filipits, Martin, Charoentong, Pornpimol, Tschurtschenthaler, Markus, Kenner, Lukas, Awad, Monira, Stift, Judith, Schernthanner, Marina, Bischl, Romana, Herndler-Brandstetter, Dietmar, Glitzner, Elisabeth, Moll, Herwig P., Casanova, Emilio, Timelthaler, Gerald, Sibilia, Maria, Gnant, Michael, Lax, Sigurd

Publikováno v: Communications Biology; 5/22/2020, Vol. 3 Issue 1, p1-14, 14p

IDO1 + Paneth cells promote immune escape of colorectal cancer

Autor: Pflügler, Sandra, Svinka, Jasmin, Scharf, Irene, Crncec, Ilija, Filipits, Martin, Charoentong, Pornpimol, Tschurtschenthaler, Markus, Kenner, Lukas, Awad, Monira, Stift, Judith, Schernthanner, Marina, Bischl, Romana, Herndler-Brandstetter, Dietmar, Glitzner, Elisabeth, Moll, Herwig P., Casanova, Emilio, Timelthaler, Gerald, Sibilia, Maria, Gnant, Michael, Lax, Sigurd, Thaler, Josef, Müller, Mathias, Strobl, Birgit, Mohr, Thomas, Kaser, Arthur, Trajanoski, Zlatko, Heller, Gerwin, Eferl, Robert

Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b1d0f83bd66705c9519bb3c74fc916

IDO1 ⁺ Paneth cells promote immune escape of colorectal cancer.

Autor: Pflügler S; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Svinka J; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Scharf I; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Crncec I; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Filipits M; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Charoentong P; Institute of Bioinformatics, Medical University Innsbruck, Biocenter, 6020, Innsbruck, Austria.; Department of Medical Oncology, National Center for Tumor diseases, University Hospital Heidelberg, 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Tschurtschenthaler M; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, 81675, Munich, Germany., Kenner L; Ludwig Boltzmann Institute for Cancer Research LBICR, 1090, Vienna, Austria.; Institute of Clinical Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Department of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Awad M; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Stift J; Institute of Clinical Pathology, Medical University of Vienna, 1090, Vienna, Austria., Schernthanner M; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Bischl R; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Herndler-Brandstetter D; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Glitzner E; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Moll HP; Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090, Vienna, Austria., Casanova E; Ludwig Boltzmann Institute for Cancer Research LBICR, 1090, Vienna, Austria.; Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090, Vienna, Austria., Timelthaler G; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Sibilia M; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Gnant M; Department of Surgery, Breast Health Center, Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria., Lax S; Department of Pathology, Hospital Graz II, 8020, Graz, Austria.; Institute of Pathology and Molecular Pathology, Johannes Kepler University, 4040, Linz, Austria., Thaler J; Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, 4600, Wels, Austria., Müller M; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Strobl B; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Mohr T; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Kaser A; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Trajanoski Z; Institute of Bioinformatics, Medical University Innsbruck, Biocenter, 6020, Innsbruck, Austria., Heller G; Division of Oncology, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria., Eferl R; Institute of Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090, Vienna, Austria. robert.eferl@meduniwien.ac.at.

Publikováno v: Communications biology [Commun Biol] 2020 May 22; Vol. 3 (1), pp. 252. Date of Electronic Publication: 2020 May 22.