Single-cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity.

Autor: Narmada BC; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672; Experimental Drug Development Centre, A∗STAR, 10 Biopolis Way, Chromos, Singapore 138670, Singapore., Khakpoor A; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Shirgaonkar N; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672., Narayanan S; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Aw PPK; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672., Singh M; Bioinformatics Institute, A∗STAR, 30 Biopolis Street, Matrix, Singapore 138671, Singapore., Ong KH; Bioinformatics Institute, A∗STAR, 30 Biopolis Street, Matrix, Singapore 138671, Singapore., Owino CO; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ng JWT; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yew HC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Binte Mohamed Nasir NS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Au VB; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Sng R; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Khine HHTW; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., di Tocco FC; Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France., Masayuki O; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore 169856, Singapore., Naikar S; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore 169856, Singapore., Ng HX; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chia SL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Seah CXY; Department of Medicine, National University Hospital, Singapore., Alnawaz MH; Department of Medicine, National University Hospital, Singapore., Wai CLY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tay AYL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Mangat KS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chew V; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore 169856, Singapore., Yu W; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore; Bioinformatics Institute, A∗STAR, 30 Biopolis Street, Matrix, Singapore 138671, Singapore., Connolly JE; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute of Biomedical Studies, Baylor University, Waco, TX, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Periyasamy G; Experimental Drug Development Centre, A∗STAR, 10 Biopolis Way, Chromos, Singapore 138670, Singapore., Plissonnier ML; Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France., Levrero M; Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France; Department of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, France; Department of Medicine SCIAC and the Italian Institute of Technology (IIT) Center for Life Nanosciences (CLNS), University of Rome La Sapienza, Rome, Italy., Lim SG; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore; Department of Medicine, National University Hospital, Singapore; Division of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore. Electronic address: mdclimsg@nus.edu.sg., DasGupta R; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672. Electronic address: dasguptar@gis.a-star.edu.sg.

Publikováno v: Journal of hepatology [J Hepatol] 2024 Jul; Vol. 81 (1), pp. 42-61. Date of Electronic Publication: 2024 Feb 28.

Single-virion sequencing of lamivudine-treated HBV populations reveal population evolution dynamics and demographic history.

Autor: Zhu YO; Genome Institute of Singapore, Singapore, 138672, Singapore. yuanzhu26@gmail.com., Aw PPK; Genome Institute of Singapore, Singapore, 138672, Singapore., de Sessions PF; Genome Institute of Singapore, Singapore, 138672, Singapore., Hong S; Genome Institute of Singapore, Singapore, 138672, Singapore., See LX; Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Hong LZ; Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Wilm A; Genome Institute of Singapore, Singapore, 138672, Singapore., Li CH; Genome Institute of Singapore, Singapore, 138672, Singapore., Hue S; London School of Hygiene and Tropical Medicine, London, UK., Lim SG; National University Hospital, Singapore, 119074, Singapore., Nagarajan N; Genome Institute of Singapore, Singapore, 138672, Singapore., Burkholder WF; Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Hibberd M; Genome Institute of Singapore, Singapore, 138672, Singapore.; London School of Hygiene and Tropical Medicine, London, UK.

Publikováno v: BMC genomics [BMC Genomics] 2017 Oct 27; Vol. 18 (1), pp. 829. Date of Electronic Publication: 2017 Oct 27.