Covalent Aurora A regulation by the metabolic integrator coenzyme A

Autor: Yugo Tsuchiya, Dominic P. Byrne, Selena G. Burgess, Jenny Bormann, Jovana Baković, Yueyang Huang, Alexander Zhyvoloup, Bess Yi Kun Yu, Sew Peak-Chew, Trang Tran, Fiona Bellany, Alethea B. Tabor, AW Edith Chan, Lalitha Guruprasad, Oleg Garifulin, Valeriy Filonenko, Matthias Vonderach, Samantha Ferries, Claire E. Eyers, John Carroll, Mark Skehel, Richard Bayliss, Patrick A. Eyers, Ivan Gout

Publikováno v: Redox Biology, Vol 28, Iss , Pp - (2020)

Aurora A kinase is a master mitotic regulator whose functions are controlled by several regulatory interactions and post-translational modifications. It is frequently dysregulated in cancer, making Aurora A inhibition a very attractive antitumor targ

Externí odkaz: https://doaj.org/article/0b4c8d09c14d4fdebd87d9bb7b34b081

Covalent Aurora A regulation by the metabolic integrator coenzyme A

Autor: Bess Yi Kun Yu, Alexander Zhyvoloup, Richard Bayliss, Mark Skehel, John L. Carroll, Trang M. Tran, Claire E. Eyers, Yugo Tsuchiya, Samantha Ferries, Ivan Gout, Fiona Bellany, Jovana Baković, Valeriy Filonenko, Selena G. Burgess, Lalitha Guruprasad, Yueyang Huang, Aw Edith Chan, Sew Y. Peak-Chew, Jenny Bormann, Matthias Vonderach, Oleg Garifulin, Alethea B. Tabor, Patrick A. Eyers, Dominic P. Byrne

Publikováno v: Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)

Aurora A kinase is a master mitotic regulator whose functions are controlled by several regulatory interactions and post-translational modifications. It is frequently dysregulated in cancer, making Aurora A inhibition a very attractive antitumor targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c870c2e91d80ca1c1f6f8af1beb10abe
https://doi.org/10.1016/j.redox.2019.101318

Corrigendum to 'Design and synthesis of Coenzyme A analogues as Aurora kinase A inhibitors: An exploration of the roles of the pyrophosphate and pantetheine moieties'. [Bioorg. Med. Chem. 28 (2020) 115740].

Autor: Bellany F; Department of Chemistry, UCL, Christopher Ingold Building, 20, Gordon Street, London WC1H 0AJ, UK., Tsuchiya Y; Department of Structural and Molecular Biology, UCL, Gower Street, London WC1E 6BT, UK., Tran TM; Department of Chemistry, UCL, Christopher Ingold Building, 20, Gordon Street, London WC1H 0AJ, UK., Edith Chan AW; Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Allan H; Department of Chemistry, UCL, Christopher Ingold Building, 20, Gordon Street, London WC1H 0AJ, UK., Gout I; Department of Structural and Molecular Biology, UCL, Gower Street, London WC1E 6BT, UK., Tabor AB; Department of Chemistry, UCL, Christopher Ingold Building, 20, Gordon Street, London WC1H 0AJ, UK. Electronic address: a.b.tabor@ucl.ac.uk.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jun 15; Vol. 40, pp. 116106. Date of Electronic Publication: 2021 May 10.

ScaffoldGraph: an open-source library for the generation and analysis of molecular scaffold networks and scaffold trees.

Autor: Scott OB; Wolfson Institute of Biomedical Research, University College London, London WC1E 6BT, UK., Edith Chan AW; Wolfson Institute of Biomedical Research, University College London, London WC1E 6BT, UK.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2020 Jun 01; Vol. 36 (12), pp. 3930-3931.

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis.

Autor: Al-Izki S; 1 Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Pryce G, Hankey DJ, Lidster K, von Kutzleben SM, Browne L, Clutterbuck L, Posada C, Edith Chan AW, Amor S, Perkins V, Gerritsen WH, Ummenthum K, Peferoen-Baert R, van der Valk P, Montoya A, Joel SP, Garthwaite J, Giovannoni G, Selwood DL, Baker D

Publikováno v: Brain : a journal of neurology [Brain] 2014 Jan; Vol. 137 (Pt 1), pp. 92-108. Date of Electronic Publication: 2013 Nov 27.