Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Avtar Roopra"'
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-6 (2022)
Measurement(s) Ventral spinal cord gene expression Technology Type(s) RNA Sequencing Factor Type(s) Ventral spinal cord gene expression Sample Characteristic - Organism Rattus norvegicus Sample Characteristic - Location United States
Externí odkaz:
https://doaj.org/article/e701c16a3d60472a81477ff6b990f8db
Autor:
Eric M. C. Britigan, Jun Wan, Daniel K. Sam, Sarah E. Copeland, Amber L. Lasek, Laura C. F. Hrycyniak, Lei Wang, Anjon Audhya, Mark E. Burkard, Avtar Roopra, Beth A. Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Increased Aurora B protein expression, which is common in cancers, is expected to increase Aurora B kinase activity, yielding elevated phosphorylation of Aurora B substrates. In contrast, here we show that elevated expression of Aurora B reduces phos
Externí odkaz:
https://doaj.org/article/6fbce553832f4f44b8f03156cb8b9c18
Autor:
David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independe
Externí odkaz:
https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
Autor:
Avtar Roopra
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007800 (2020)
Transcriptomic profiling is an immensely powerful hypothesis generating tool. However, accurately predicting the transcription factors (TFs) and cofactors that drive transcriptomic differences between samples is challenging. A number of algorithms dr
Externí odkaz:
https://doaj.org/article/d459d4e5e2b64aef93feef5437e244b5
Autor:
Grace H. Yang, Danielle A. Fontaine, Sukanya Lodh, Joseph T. Blumer, Avtar Roopra, Dawn Belt Davis
Publikováno v:
Metabolites, Vol 11, Iss 8, p 513 (2021)
Transcription factor 19 (TCF19) is a gene associated with type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in genome-wide association studies. Prior studies have demonstrated that Tcf19 knockdown impairs β-cell proliferation and increases apoptosis
Externí odkaz:
https://doaj.org/article/2cd58b81ff084eec979f4d8c421ee859
A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy.
Autor:
Nadia Khan, Barry Schoenike, Trina Basu, Heidi Grabenstatter, Genesis Rodriguez, Caleb Sindic, Margaret Johnson, Eli Wallace, Rama Maganti, Raymond Dingledine, Avtar Roopra
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226733 (2019)
Complex neurological conditions can give rise to large scale transcriptomic changes that drive disease progression. It is likely that alterations in one or a few transcription factors or cofactors underlie these transcriptomic alterations. Identifyin
Externí odkaz:
https://doaj.org/article/7b16ff352c504ff69b9de432ae5aa2b8
Autor:
Judith Kimble, William M Bement, Qiang Chang, Benjamin L Cox, Norman R Drinkwater, Richard L Gourse, Aaron A Hoskins, Anna Huttenlocher, Pamela K Kreeger, Paul F Lambert, Marsha R Mailick, Shigeki Miyamoto, Richard L Moss, Kate M O'Connor-Giles, Avtar Roopra, Krishanu Saha, Hannah S Seidel
Publikováno v:
eLife, Vol 4 (2015)
A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
Externí odkaz:
https://doaj.org/article/977f332b05b245bbb249d515b2ab0389
Autor:
Ildiko Kasza, Yewseok Suh, Damian Wollny, Rod J Clark, Avtar Roopra, Ricki J Colman, Ormond A MacDougald, Timothy A Shedd, David W Nelson, Mei-I Yen, Chi-Liang Eric Yen, Caroline M Alexander
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004514 (2014)
Homeostatic temperature regulation is fundamental to mammalian physiology and is controlled by acute and chronic responses of local, endocrine and nervous regulators. Here, we report that loss of the heparan sulfate proteoglycan, syndecan-1, causes a
Externí odkaz:
https://doaj.org/article/0a76c60c6a304b0f8220dd2a001ef965
Autor:
Wyatt B Potter, Trina Basu, Kenneth J O'Riordan, Allison Kirchner, Paul Rutecki, Corinna Burger, Avtar Roopra
Publikováno v:
PLoS Biology, Vol 11, Iss 8, p e1001627 (2013)
Tuberous sclerosis complex (TSC) is a multisystem genetic disease that manifests with mental retardation, tumor formation, autism, and epilepsy. Heightened signaling through the mammalian target of rapamycin (mTOR) pathway is involved in TSC patholog
Externí odkaz:
https://doaj.org/article/acd6306d86874cb3b4e33308045d9d42
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58039 (2013)
Recent studies showed that stroke extensively alters cerebral microRNA (miRNA) expression profiles and several miRNAs play a role in mediating ischemic pathophysiology. We currently evaluated the significance of miR-29c, a highly expressed miRNA in r
Externí odkaz:
https://doaj.org/article/9f7298b2636e46d2b02583f691f49b23