Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans

Autor: Kyle J. Bourassa, Melanie E. Garrett, Avshalom Caspi, Michelle Dennis, Katherine S. Hall, Terrie E. Moffitt, Gregory A. Taylor, VA Mid Atlantic MIRECC Workgroup, Allison E. Ashley-Koch, Jean C. Beckham, Nathan A. Kimbrel

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chr

Externí odkaz: https://doaj.org/article/b51e1b2dce5d4bbd811db301aeae131b

A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator

Autor: Trevor Doherty, Emma Dempster, Eilis Hannon, Jonathan Mill, Richie Poulton, David Corcoran, Karen Sugden, Ben Williams, Avshalom Caspi, Terrie E. Moffitt, Sarah Jane Delany, Therese M. Murphy

Publikováno v: BMC Bioinformatics, Vol 24, Iss 1, Pp 1-30 (2023)

Abstract Background The field of epigenomics holds great promise in understanding and treating disease with advances in machine learning (ML) and artificial intelligence being vitally important in this pursuit. Increasingly, research now utilises DNA

Externí odkaz: https://doaj.org/article/ed3e470c949d4918a16717e70d5601bf

Genetic association study of childhood aggression across raters, instruments, and age

Autor: Hill F. Ip, Camiel M. van der Laan, Eva M. L. Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M. Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A. Wang, Gretchen Saunders, Ville Karhunen, Anke R. Hammerschlag, Daniel E. Adkins, Richard Border, Roseann E. Peterson, Joseph A. Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S. Ahluwalia, Felix R. Day, Jouke-Jan Hottenga, Andrea G. Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J. Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G. Scott, Anna Vinkhuyzen, Andrey A. Shabalin, Robin Corley, Luke M. Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E. Davies, Erik A. Ehli, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C.E.M. Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C. Verhulst, Najaf Amin, Alyce M. Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J. Rose, André G. Uitterlinden, Andrew C. Heath, Pamela Madden, Jan Haavik, Jennifer R. Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S. Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K. Henders, Abdullah Mamun, Jackob M. Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L. Wall, Judy L. Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T. Raitakari, John R. B. Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L. John Horwood, Martin Kennedy, Richie Poulton, Lindon J. Eaves, Hermine H. Maes, John Hewitt, William E. Copeland, Elizabeth J. Costello, Gail M. Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E. Moffitt, Andrew Whitehouse, Craig E. Pennell, Kelly L. Klump, S. Alexandra Burt, Danielle M. Dick, Ted Reichborn-Kjennerud, Nicholas G. Martin, Sarah E. Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A. Hartman, Albertine J. Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors

Externí odkaz: https://doaj.org/article/882fa84e3ace4249a3c5e7bb582ea021

DunedinPACE, a DNA methylation biomarker of the pace of aging

Autor: Daniel W Belsky, Avshalom Caspi, David L Corcoran, Karen Sugden, Richie Poulton, Louise Arseneault, Andrea Baccarelli, Kartik Chamarti, Xu Gao, Eilis Hannon, Hona Lee Harrington, Renate Houts, Meeraj Kothari, Dayoon Kwon, Jonathan Mill, Joel Schwartz, Pantel Vokonas, Cuicui Wang, Benjamin S Williams, Terrie E Moffitt

Publikováno v: eLife, Vol 11 (2022)

Background: Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans. Previously, we showed that quantification of the pace of biological aging from a DNA-

Externí odkaz: https://doaj.org/article/ed8e667fe7084ba990e0b7e3f557bdcc

Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter

Autor: Tracy d'Arbeloff, Maxwell L. Elliott, Annchen R. Knodt, Maria Sison, Tracy R. Melzer, David Ireland, Sandhya Ramrakha, Richie Poulton, Avshalom Caspi, Terrie E. Moffitt, Ahmad R. Hariri

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

Disappointing results from clinical trials designed to delay structural brain decline and the accompanying increase in risk for dementia in older adults have precipitated a shift in testing promising interventions from late in life toward midlife bef

Externí odkaz: https://doaj.org/article/733383ad0b1a4679b521b11816a5e948