Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Avrum E. Spira"'
Autor:
Ke Xu, Xingyi Shi, Christopher Husted, Rui Hong, Yichen Wang, Boting Ning, Travis B. Sullivan, Kimberly M. Rieger-Christ, Fenghai Duan, Helga Marques, Adam C. Gower, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Grant Duclos, Michael Platt, Avrum E. Spira, Sarah A. Mazzilli, Ehab Billatos, Marc E. Lenburg, Joshua D. Campbell, Jennifer E. Beane
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene expression patterns in the airway epithelium. The similarities and differences of VE gene expression (ACE2, TMPRSS2, and CTSL) across nasal and bronchial compa
Externí odkaz:
https://doaj.org/article/ba234dab333940e49f16b1217758cc45
Autor:
Linda L. Garland, José Guillen-Rodriguez, Chiu-Hsieh Hsu, Lisa E. Davis, Eva Szabo, Christopher R. Husted, Hanqiao Liu, Ashley LeClerc, Yuriy O. Alekseyev, Gang Liu, Julie E. Bauman, Avrum E. Spira, Jennifer Beane, Malgorzata Wojtowicz, H.-H. Sherry Chow
Publikováno v:
Cancers, Vol 14, Iss 12, p 2893 (2022)
The chemopreventive effect of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on lung cancer risk is supported by epidemiologic and preclinical studies. Zileuton, a 5-lipoxygenase inhibitor, has additive activity with NSAIDs against
Externí odkaz:
https://doaj.org/article/9e10e59aaf744572bdf13f4d9d4b851b
Autor:
Jennifer E. Beane, Sarah A. Mazzilli, Joshua D. Campbell, Grant Duclos, Kostyantyn Krysan, Christopher Moy, Catalina Perdomo, Michael Schaffer, Gang Liu, Sherry Zhang, Hanqiao Liu, Jessica Vick, Samjot S. Dhillon, Suso J. Platero, Steven M. Dubinett, Christopher Stevenson, Mary E. Reid, Marc E. Lenburg, Avrum E. Spira
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune
Externí odkaz:
https://doaj.org/article/0cf5153a221648e9910fbb6ff4aaf085
Autor:
Guangchun Han, Ansam Sinjab, Kieko Hara, Warapen Treekitkarnmongkol, Patrick Brennan, Kyle Chang, Elena Bogatenkova, Beatriz Sanchez-Espiridion, Carmen Behrens, Luisa M. Solis, Boning Gao, Luc Girard, Jianjun Zhang, Boris Sepesi, Tina Cascone, Lauren A. Byers, Don L. Gibbons, Jichao Chen, Seyed Javad Moghaddam, Edwin J. Ostrin, Paul Scheet, Junya Fujimoto, Jerry Shay, John V. Heymach, John D. Minna, Steven Dubinett, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum E. Spira, Linghua Wang, Humam Kadara
Publikováno v:
Cancers, Vol 13, Iss 6, p 1250 (2021)
The novel coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Severely symptomatic COVID-19 is associated with lung inflammation, pneumonia, and respiratory failure, thereby raising concerns of elevated risk of COVID-19-associated
Externí odkaz:
https://doaj.org/article/54bf6a35709648349b0d9a29fd8dafef
Autor:
Humam Kadara, Avrum E. Spira, Junya Fujimoto, Paul Scheet, Ignacio I. Wistuba, Arafat Tfayli, Hassan Chami, Nadine Darwiche, Georges Nemer, Junya Fukuoka, Sayuri Nunomura-Nakamura, Wenhua Lang, Smruthy Sivakumar, Tina L. McDowell, Li Xu, Ansam Sinjab, Jacob Kantrowitz
Smoking perpetuates in cytologically normal airways a molecular “field of injury” that is pertinent to lung cancer and early detection. The evolution of airway field changes prior to lung oncogenesis is poorly understood largely due to the long l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e17e9900f6b54bea4f91e241866843c
https://doi.org/10.1158/1940-6207.c.6547019
https://doi.org/10.1158/1940-6207.c.6547019
Autor:
Steven M. Dubinett, David Elashoff, Avrum E. Spira, Sherven Sharma, Marc E. Lenburg, Edward B. Garon, Tonya C. Walser, Karen L. Reckamp, James O'Hearn, Tristan Grogan, Rebecca Kusko, Kostyantyn Krysan
PDF file - 37K, Stable knockdown of c-myc expression by shRNA in NSCLC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f063a324be5be9896189e412c15d59
https://doi.org/10.1158/1541-7786.22510579.v1
https://doi.org/10.1158/1541-7786.22510579.v1
Autor:
Humam Kadara, Avrum E. Spira, Junya Fujimoto, Paul Scheet, Ignacio I. Wistuba, Arafat Tfayli, Hassan Chami, Nadine Darwiche, Georges Nemer, Junya Fukuoka, Sayuri Nunomura-Nakamura, Wenhua Lang, Smruthy Sivakumar, Tina L. McDowell, Li Xu, Ansam Sinjab, Jacob Kantrowitz
Supplementary Tables Table S1. Early efffcts of NNK exposure on the mouse airway transcriptome. Table S2. Evolutionarily conserved decreased gene expression in the airway following NNK exposure. Table S3. Genes differentially regulated in the mouse a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f23225b5af3e7710a7aeda36e67677
https://doi.org/10.1158/1940-6207.22533305.v1
https://doi.org/10.1158/1940-6207.22533305.v1
Autor:
Eva Szabo, Paul J. Limburg, Jennifer Beane, Avrum E. Spira, Judith Smith, William S. Harmsen, Henry Tazelaar, Joanne (Eunhee) Yi, John Mayo, Diana N. Ionescu, Marc E. Lenburg, Andrea Bild, Evan Johnson, Gang Liu, Tawimas Shaipanich, Don D. Sin, Annette McWilliams, Marie Christine Aubry, Jenny T. Mao, David E. Midthun, Drew K. Seisler, Katie L. Allen Ziegler, Yaron Gesthalter, Sumithra J. Mandrekar, Stephen Lam
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697674f2c08d0f92a565352948be0ddd
https://doi.org/10.1158/1940-6207.22534535.v1
https://doi.org/10.1158/1940-6207.22534535.v1
Autor:
Eva Szabo, Paul J. Limburg, Jennifer Beane, Avrum E. Spira, Judith Smith, William S. Harmsen, Henry Tazelaar, Joanne (Eunhee) Yi, John Mayo, Diana N. Ionescu, Marc E. Lenburg, Andrea Bild, Evan Johnson, Gang Liu, Tawimas Shaipanich, Don D. Sin, Annette McWilliams, Marie Christine Aubry, Jenny T. Mao, David E. Midthun, Drew K. Seisler, Katie L. Allen Ziegler, Yaron Gesthalter, Sumithra J. Mandrekar, Stephen Lam
Previous preclinical studies and a phase I clinical trial suggested that myo-inositol may be a safe and effective lung cancer chemopreventive agent. We conducted a randomized, double blind, placebo-controlled phase IIb study to determine the chemopre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48c20f1d364e214b061664b2f55d1d43
https://doi.org/10.1158/1940-6207.c.6547538.v1
https://doi.org/10.1158/1940-6207.c.6547538.v1
Autor:
Humam Kadara, Avrum E. Spira, Junya Fujimoto, Paul Scheet, Ignacio I. Wistuba, Arafat Tfayli, Hassan Chami, Nadine Darwiche, Georges Nemer, Junya Fukuoka, Sayuri Nunomura-Nakamura, Wenhua Lang, Smruthy Sivakumar, Tina L. McDowell, Li Xu, Ansam Sinjab, Jacob Kantrowitz
Supplementary Methods and Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7693af3937eb24987fe5de80c8fa438
https://doi.org/10.1158/1940-6207.22533311.v1
https://doi.org/10.1158/1940-6207.22533311.v1