Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Avril Coghlan"'
Autor:
Avril Coghlan, Frederick A Partridge, María Adelaida Duque-Correa, Gabriel Rinaldi, Simon Clare, Lisa Seymour, Cordelia Brandt, Tapoka T Mkandawire, Catherine McCarthy, Nancy Holroyd, Marina Nick, Anwen E Brown, Sirapat Tonitiwong, David B Sattelle, Matthew Berriman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011205 (2023)
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for oth
Externí odkaz:
https://doaj.org/article/a9399883925e4c239ce6cfe85ef5286d
Autor:
Kate A. Rawlinson, Adam J. Reid, Zhigang Lu, Patrick Driguez, Anna Wawer, Avril Coghlan, Geetha Sankaranarayanan, Sarah K. Buddenborg, Carmen Diaz Soria, Catherine McCarthy, Nancy Holroyd, Mandy Sanders, Karl F. Hoffmann, David Wilcockson, Gabriel Rinaldi, Matthew Berriman
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background The consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimise their fitness. U
Externí odkaz:
https://doaj.org/article/9c514beb10074835b2b16a2af319d0f5
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
More than a billion people are infected with parasitic worms, including nematodes, such as hookworms, and flatworms, such as blood flukes. Few drugs are available to treat worm infections, but high-throughput screening approaches hold promise to iden
Externí odkaz:
https://doaj.org/article/e3082db7b8294ed899c342fca94eeb51
Autor:
Gilda Padalino, Avril Coghlan, Giampaolo Pagliuca, Josephine E. Forde-Thomas, Matthew Berriman, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1359 (2023)
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective vaccine is registered for use, the cornerstone of schistosomiasis control remains chemotherapy with praziquantel. The sustainability of this strategy is at s
Externí odkaz:
https://doaj.org/article/45e27b46d0fb4961ac6c0c9f61f8ecce
Autor:
Carmen Lidia Diaz Soria, Jayhun Lee, Tracy Chong, Avril Coghlan, Alan Tracey, Matthew D. Young, Tallulah Andrews, Christopher Hall, Bee Ling Ng, Kate Rawlinson, Stephen R. Doyle, Steven Leonard, Zhigang Lu, Hayley M. Bennett, Gabriel Rinaldi, Phillip A. Newmark, Matthew Berriman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Schistosomes undergo several develepmental stages during infection of humans. Here, the authors perform single-cell RNA sequencing on the earliest intra-mammalian stage of Schistosoma mansoni and generate a comprehensive cell-type atlas for this huma
Externí odkaz:
https://doaj.org/article/6109b043f8874e20a199d8e36e8d9e78
Autor:
Geetha Sankaranarayanan, Avril Coghlan, Patrick Driguez, Magda E. Lotkowska, Mandy Sanders, Nancy Holroyd, Alan Tracey, Matthew Berriman, Gabriel Rinaldi
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
Background. At least 250 million people worldwide suffer from schistosomiasis, caused by Schistosoma worms. Genome sequences for several Schistosoma species are available, including a high-quality annotated reference for Schistosoma mansoni. There is
Externí odkaz:
https://doaj.org/article/002e813d7f0844b3a6df3a8d312f8671
Autor:
Helen Whiteland, Alessandra Crusco, Lisa W Bloemberg, Jamie Tibble-Howlings, Josephine Forde-Thomas, Avril Coghlan, Patrick J Murphy, Karl F Hoffmann
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008630 (2020)
BackgroundSchistosomiasis is a prevalent neglected tropical disease that affects approximately 300 million people worldwide. Its treatment is through a single class chemotherapy, praziquantel. Concerns surrounding the emergence of praziquantel insens
Externí odkaz:
https://doaj.org/article/d85a730237654388acb93a9eb883f7ba
Autor:
Geetha Sankaranarayanan, Avril Coghlan, Patrick Driguez, Magda E. Lotkowska, Mandy Sanders, Nancy Holroyd, Alan Tracey, Matthew Berriman, Gabriel Rinaldi
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background. At least 250 million people worldwide suffer from schistosomiasis, caused by Schistosoma worms. Genome sequences for several Schistosoma species are available, including a high-quality annotated reference for Schistosoma mansoni. There is
Externí odkaz:
https://doaj.org/article/962673fb93c94d0f9736f6df15d2ed9e
Autor:
Wannaporn Ittiprasert, Victoria H Mann, Shannon E Karinshak, Avril Coghlan, Gabriel Rinaldi, Geetha Sankaranarayanan, Apisit Chaidee, Toshihiko Tanno, Chutima Kumkhaek, Pannathee Prangtaworn, Margaret M Mentink-Kane, Christina J Cochran, Patrick Driguez, Nancy Holroyd, Alan Tracey, Rutchanee Rodpai, Bart Everts, Cornelis H Hokke, Karl F Hoffmann, Matthew Berriman, Paul J Brindley
Publikováno v:
eLife, Vol 8 (2019)
CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle. This secreted ribonuclease is crucial for Th2 polarization and
Externí odkaz:
https://doaj.org/article/b44d0fcb161541f696572c51b67e0c12
Autor:
Shane Woods, Avril Coghlan, David Rivers, Tobias Warnecke, Sean J Jeffries, Taejoon Kwon, Anthony Rogers, Laurence D Hurst, Julie Ahringer
Publikováno v:
PLoS Genetics, Vol 9, Iss 5, p e1003330 (2013)
When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of functional redundancy with the remaining paralog. This is supported by indirect evidence showing that multi-
Externí odkaz:
https://doaj.org/article/3ca9d34818bc4746808ed0f6a4986093