Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac:Pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system

Autor: Albertsen, BK, Schrøder, H, Ingerslev, J, Jakobsen, P, Avramis, V I, Müller, H J, Carlsen, N T, Schmiegelow, K

Publikováno v: Albertsen, B K, Schrøder, H, Ingerslev, J, Jakobsen, P, Avramis, V I, Müller, H J, Carlsen, N T & Schmiegelow, K 2001, ' Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac : Pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system ' British J of Haematology, vol. 115, pp. 983-990 .
Albertsen, BK, Schrøder, H, Ingerslev, J, Jakobsen, P, Avramis, V I, Müller, H J, Carlsen, N T & Schmiegelow, K 2001, ' Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac : pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system ', British Journal of Haematology, vol. 115, no. 4, pp. 983-90 .

Asparaginase comes from different biological sources and the various preparations have different pharmacokinetic properties, and their tendency to induce side-effects is different. Erwinia asparaginase (ASNase) has a shorter half-life than the Escher

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