Výsledky vyhledávání

Chronically altered ventricular activation causes pro-arrhythmic cardiac electrical remodelling in the chronic AV block dog model

Autor: Valerie Y H van Weperen, Iris ter Horst, Albert Dunnink, Alexandre Bossu, Odette A Salden, Henriette D M Beekman, Avram Oros, Vincent Bourgonje, Thom Stams, Mathias Meine, Marc A Vos

Publikováno v: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

AimsAltered ventricular activation (AVA) causes intraventricular mechanical dyssynchrony (MD) and impedes contraction, promoting pro-arrhythmic electrical remodelling in the chronic atrioventricular block (CAVB) dog. We aimed to study arrhythmogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d98938c389f0ac4af9eb44c0c5b8a6
https://pubmed.ncbi.nlm.nih.gov/36125234

Zobrazit plný text záznamu

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action

Autor: Ana María Gómez, Marcel A.G. van der Heyden, Sridharan Rajamani, Peter Oosterhoff, Luiz Belardinelli, Sylvain Richard, Patricia Neco, Nico J. M. Attevelt, Jet D.M. Beekman, L. Ver Donck, Avram Oros, M. Houtman, M A Vos, Gudrun Antoons

Publikováno v: British Journal of Pharmacology. 161:162-175

BACKGROUND AND PURPOSE The high predisposition to Torsade de Pointes (TdP) in dogs with chronic AV-block (CAVB) is well documented. The anti-arrhythmic efficacy and mode of action of Ca2+ channel antagonists, flunarizine and verapamil against TdP wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d17cdd7d4645908824d8184a4997d3b
https://doi.org/10.1111/j.1476-5381.2010.00883.x

Zobrazit plný text záznamu

Late Na+Current Inhibition by Ranolazine Reduces Torsades de Pointes in the Chronic Atrioventricular Block Dog Model

Autor: Jet D.M. Beekman, Avram Oros, Marien J C Houtman, Luiz Belardinelli, Marc A. Vos, Markus A. Engelen, Gudrun Antoons, Milan Stengl

Publikováno v: Journal of the American College of Cardiology. 55:801-809

This study investigated whether ranolazine reduces dofetilide-induced torsades de pointes (TdP) in a model of long QT syndrome with down-regulated K(+) currents due to hypertrophic remodeling in the dog with chronic atrioventricular block (cAVB).Rano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0895fcdd44e7ae64fe541a7b6c8f2111
https://doi.org/10.1016/j.jacc.2009.10.033

Zobrazit plný text záznamu

Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment

Autor: Karin R. Sipido, Avram Oros, Virginie Bito, Gudrun Antoons, Marc A. Vos

Publikováno v: Journal of Electrocardiology. 40:S8-S14

Malignant ventricular tachyarrhythmias are common among patients with hypertrophy and heart failure, and these arrhythmias can initiate by triggered activity. Abnormal repolarization and disturbed calcium handling due to remodeling processes are comm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd222042c1650456f9750a889983a48
https://doi.org/10.1016/j.jelectrocard.2007.05.022

Zobrazit plný text záznamu

High-Septal Pacing Reduces Ventricular Electrical Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs

Autor: Peter Oosterhoff, Leo Kretzers, Morten B. Thomsen, Jet D.M. Beekman, Stephan K.G. Winckels, Nico J. M. Attevelt, Marc A. Vos, Avram Oros

Publikováno v: Journal of the American College of Cardiology. 50:906-913

ObjectivesThis study was designed to analyze the relevance of ventricular activation patterns for ventricular electrical remodeling after atrioventricular (AV) block in dogs.BackgroundBradycardia is thought to be the main contributor to ventricular e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954e5052ffea54684cebf575e0d0d8e4
https://doi.org/10.1016/j.jacc.2007.05.019

Zobrazit plný text záznamu

Novel parameters to improve quantification of repolarization reserve and arrhythmogenesis using a dofetilide challenge

Autor: Avram Oros, Rosanne Varkevisser, R. van der Nagel, Peter Oosterhoff, T. R. G. Stams, Marlies de Vos, H D M Beekman, Stephan K.G. Winckels

Publikováno v: Heart Rhythm, 10, 1745-6
Heart Rhythm, 10, 11, pp. 1745-6

Item does not contain fulltext BACKGROUND: In the canine complete AV block (AVB) model with bradycardia, inducibility of drug-induced torsades de pointes (TdP) is usually the primary outcome parameter, whereas short-term variability (STV) of the left

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d86ecd74fd4bfe91c69998e4303d02
http://hdl.handle.net/2066/125724

Zobrazit plný text záznamu

The canine model with chronic, complete atrio-ventricular block

Autor: Avram Oros, Jet D.M. Beekman, Marc A. Vos

Publikováno v: Pharmacologytherapeutics. 119(2)

Proarrhythmic susceptibility to drug-induced Torsades de Pointes is restricted to individuals with a predisposed phenotype characterized by a reduced repolarization reserve. Additional factors are often involved in a further impairment of repolarizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad1b7b905c4c5a150af1b069df8a3a3
https://pubmed.ncbi.nlm.nih.gov/18514320

Zobrazit plný text záznamu

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

Autor: Joep N. Maas, Marieke Schoenmakers, Jurren M. van Opstal, Avram Oros, Jet D.M. Beekman, Marc A. Vos, Morten B. Thomsen

Publikováno v: Cardiovascular research. 73(3)

Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f256533400a215836e4a672fbcc6fbc
https://pubmed.ncbi.nlm.nih.gov/17196569

Zobrazit plný text záznamu

Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block

Autor: Avram Oros, Marc A. Vos, Theo van der Nagel, Paul G.A. Volders, Jet D.M. Beekman

Publikováno v: Heart rhythm. 3(11)

The novel compound AVE0118 has been shown to prevent and terminate persistent atrial fibrillation. AVE0118 blocks I(Kur), I(KAch), and I(to), leading to prolongation of atrial repolarization with no change in ventricular repolarization. This finding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d773ece77e7cee6524b122f1125ad787
https://pubmed.ncbi.nlm.nih.gov/17074641

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání