Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Avner Fink"'
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188600 (2017)
Type I interferons (IFNα, IFNβ) are key regulators of innate and adaptive immunity, modulating the severity of both viral and bacterial infections. While type I IFN signaling leads to improved outcomes in viral infections, its role in bacterial inf
Externí odkaz:
https://doaj.org/article/7bb0f2ba39d7423da3a9cfa8b56407fb
Autor:
Avner Fink, Musa A. Hassan, Nihal A. Okan, Michal Sheffer, Ana Camejo, Jeroen P. J. Saeij, Dennis L. Kasper
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Differences among individuals in susceptibility to infectious diseases can be modulated by host genetics. Much of the research in this field has aimed to identify loci within the host genome that are associated with these differences. In mic
Externí odkaz:
https://doaj.org/article/93e1f57b28df4c19b8f08d7f48160d00
Publikováno v:
mBio, Vol 4, Iss 1 (2013)
ABSTRACT The highly virulent Francisella tularensis subsp. tularensis has been classified as a category A bioterrorism agent. A live vaccine strain (LVS) has been developed but remains unlicensed in the United States because of an incomplete understa
Externí odkaz:
https://doaj.org/article/e2dbee38dec14692b0a7218af97817a5
Previously, we reported that intratumor or systemic inoculation of a cationic 15-mer, innate immunity-like lytic peptide composed of d- and l-amino acids ([D]-K6L9) caused growth arrest of 22RV1 prostate carcinoma xenografts in a mouse model. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0675a33976a9e27daf05c8dd7166ec9c
https://doi.org/10.1158/0008-5472.c.6499920.v1
https://doi.org/10.1158/0008-5472.c.6499920.v1
Supplementary Figures 1-3 from Suppression of Human Solid Tumor Growth in Mice by Intratumor and Systemic Inoculation of Histidine-Rich and pH-Dependent Host Defense–like Lytic Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba766f82db4759c132b273d684d2dc
https://doi.org/10.1158/0008-5472.22381584.v1
https://doi.org/10.1158/0008-5472.22381584.v1
Publikováno v:
European journal of immunology
Acute myeloid leukemia (AML) is a highly aggressive disease with high relapse and mortality rates. Recent years have shown a surge in novel therapeutic development for AML, both in clinical and preclinical stages. These developments include targeted
Autor:
Batya Zarmi, Biana Bernshtein, Avner Fink, Steffen Jung, Liraz Shmuel-Galia, Tegest Aychek, Ori Brenner, Yechiel Shai, Ziv Porat
Publikováno v:
The EMBO Journal. 35:685-698
Monocytes have emerged as critical driving force of acute inflammation. Here, we show that inhibition of Toll‐like receptor 2(TLR2) dimerization by a TLR2 transmembrane peptide (TLR2‐p) ameliorated DSS‐induced colitis by interfering specificall
Autor:
Guy Brachya, Yinon Ben-Neriah, Moshe Oren, Liran I. Shlush, Itay Omer, Amitai Rivlin, Robert W. Sullivan, Eli Pikarsky, Nathali Kaushansky, Li Dansu, Adar Zinger, Frank Mercurio, Ross L. Levine, Eitan Winter, Waleed Minzel, Ido Burstain, Avanthika Venkatachalam, Joseph Vacca, Leah Fung, Eric Hung, Maya Shaham, Irit Snir-Alkalay, Avner Fink, Paul Erdman, Shlomo Elias
Summary CKIα ablation induces p53 activation, and CKIα degradation underlies the therapeutic effect of lenalidomide in a pre-leukemia syndrome. Here we describe the development of CKIα inhibitors, which co-target the transcriptional kinases CDK7 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2440625cc9c49007ec76bcf64decbae
https://europepmc.org/articles/PMC6701634/
https://europepmc.org/articles/PMC6701634/
Autor:
Kensuke Tateishi, Erik A. Williams, Joshua M. Francis, Jochen K. Lennerz, Anthony J. Iafrate, Julie M. Batten, Hiroaki Wakimoto, Koerner Mva, Fumi Higuchi, Tracy T. Batchelor, Stephen P. Schmidt, Barker Fg nd, Aymen Baig, Gregory R. Wojtkiewicz, Andrew S. Chi, Tai Tammy, Priscilla K. Brastianos, Tristan Penson, Robert Langer, Giovanni Traverso, William T. Curry, Shilpa S. Tummala, Julie J. Miller, Ameya R. Kirtane, Mikael L. Rinne, Jaimie Rogner, Matthew Meyerson, Hormoz Mazdiyasni, Daniel P. Cahill, Avner Fink, Ganesh M. Shankar, Justin T. Jordan, Tareq A. Juratli
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Aggressive neurosurgical resection to achieve sustained local control is essential for prolonging survival in patients with lower-grade glioma. However, progression in many of these patients is characterized by local regrowth. Most lower-grade glioma
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188600 (2017)
PLoS ONE, Vol 12, Iss 11, p e0188600 (2017)
Type I interferons (IFNα, IFNβ) are key regulators of innate and adaptive immunity, modulating the severity of both viral and bacterial infections. While type I IFN signaling leads to improved outcomes in viral infections, its role in bacterial inf