Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Avneesh Saini"'
Autor:
Maya Kotturi, Mélanie Desbois, Angus Sinclair, Thierry Giffon, Dean Ng, Poonam Yakkundi, Marigold Manlusoc, Rodnie Rosete, Avneesh Saini, Bruce Keyt, Daniel Machado, Miho Oyasu, Susan Calhoun, Tasnim Kothambawala, Beatrice Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/7407df17c8fd4aeeb4c9fb58b7d3aba4
Autor:
Angus Sinclair, Thierry Giffon, Dean Ng, Poonam Yakkundi, Hope Lancero, Marigold Manlusoc, Rodnie Rosete, Avneesh Saini, Madeline Tran, Kevin Carlin, Chitra Saraiya, Ramesh Baliga, Bruce Keyt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/f409f288839b4ef28aeb52ed133e3d6e
Autor:
Mélanie Desbois, Thierry Giffon, Poonam Yakkundi, Sivani Pandey, Rodnie Rosete, Daniel Machado, Marigold Manlusoc, Susan Calhoun, Tasnim Kothambawala, Jey Ananta, Kristina Koyama, Yuan Cao, Dean Ng, Tomas Miranda-Katz, Avneesh Saini, Abhinav Jain, Hongjun Yue, Yang Cai, Miho Oyasu, Liz Bogaert, Roel Funke, Genevive Hernandez, Denise Nagata, Maya Leabman, Eric Humke, Stephen Carroll, Beatrice Wang, Bruce Keyt, Angus Sinclair, Maya Kotturi
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Thierry Giffon, Melanie Desbois, Poonam Yakkundi, Keerthana Sekar, Marigold Manlusoc, Rodnie Rosete, Daniel Machado, Susan Calhoun, Tasnim Kothambawala, Dean Ng, Vu Tran, Avneesh Saini, Abhinav Jain, Beatrice Wang, Maya Kotturi, Bruce Keyt, Angus Sinclair
Publikováno v:
Cancer Research. 82:3438-3438
Anti-PD-1/PD-L1 therapies are efficacious in certain cancer indications, but often patients relapse following a primary response Therefore rational combinations are needed to enhance initial and durable responses of anti-PD-1/PD-L1 therapies. Immunos
Autor:
Tasnim Kothambawala, Genevive Hernandez, Angus M. Sinclair, Bruce Keyt, Ling Wang, Marvin Peterson, Thomas J. Matthew, Beatrice Tien-Yi Wang, Avneesh Saini, Susan E. Calhoun, Eric W. Humke, Maya Kotturi
Publikováno v:
Molecular cancer therapeutics. 20(12)
Death receptor 5 (DR5) is an attractive target for cancer therapy due to its broad upregulated expression in multiple cancers and ability to directly induce apoptosis. Though anti-DR5 IgG antibodies have been evaluated in clinical trials, limited eff
Autor:
Rodnie Rosete, Poonam Yakkundi, Bruce Keyt, Thierry Giffon, Kevin Carlin, Ramesh Baliga, Dean Ng, Avneesh Saini, Hope Lancero, Marigold Manlusoc, Angus M. Sinclair, Madeline Tran, Chitra Saraiya
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Therapeutic antibodies inhibiting PD-1/PD-L1 have demonstrated clinical efficacy though only a fraction of patients respond. Combinations are being explored to enhance responses including anti-PD-1/PD-L1 IgG antibodies with IL-15-pathway s
Autor:
Bruce Keyt, Avneesh Saini, Susan E. Calhoun, Mélanie Desbois, Rodnie Rosete, Poonam Yakkundi, Angus M. Sinclair, Tasnim Kothambawala, Miho Oyasu, Maya Kotturi, Beatrice Tien-Yi Wang, Dean Ng, Thierry Giffon, Marigold Manlusoc, Daniel Machado
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundWhile approved PD-1/PD-L1 inhibitory antibodies have demonstrated clinical efficacy in certain cancer patients, relapse following a primary response is often observed. Enhancing anti-tumor immune responses with an immunostimulatory cytokine
Autor:
Paul Hinton, Bruce Keyt, Daniel S. Chen, Madeline H. Tran, Chitra Saraiya, Ramesh Baliga, Stephen F. Carroll, Dean C. Ng, Marigold Manlusoc, Hai Lu, Yuan C. Cao, Sachi Rahman, Bing Shan, Marvin Peterson, Keyu Li, Avneesh Saini
Publikováno v:
Cancer Research. 80:5664-5664
We have developed a novel T cell engaging bispecific antibody platform that utilizes the high avidity of IgM antibodies, but further combines this with the high affinity and specificity of IgG antibodies. By grafting the affinity matured binding doma
Autor:
Bruce Keyt, Chitra Saraiya, Dean Ng, Ramesh Baliga, Steve Carroll, Avneesh Saini, Paul Hinton, Sachi Rahman, Keyu Li, Madeline Tran, Bing Shan, Marigold Manlusoc, Hai Lu, Marvin Peterson, Yuan Cao, Wayne R. Godfrey
Publikováno v:
Journal of Clinical Oncology. 38:e15007-e15007
e15007 Background: Bispecific antibodies which tether T-cells to cancer cells, and additionally activate T-cell mediated killing, have shown promise in treating B-cell malignancies. Dose intensity, however, is limited by cytokine release from the act
Autor:
Steve Carroll, Marvin Peterson, Marigold Manlusoc, Bing Shan, Hai Lu, Sachi Rahman, Ramesh Baliga, Paul Hinton, Yuan Cao, Chitra Saraiya, Bruce Keyt, Daniel S. Chen, Dean Ng, Keyu Li, Madeline Tran, Avneesh Saini
Publikováno v:
Blood. 134:1574-1574
Unlike IgG antibodies, IgM antibodies are typically composed of a pentameric disc-like structure with 10 low affinity binding sites per molecule complexed with a joining chain (J-chain) protein. We have developed a novel T cell engaging bispecific an