Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aviva T. Horowitz"'
Autor:
Aviva T. Horowitz, Samuel Zalipsky, Dinah Tzemach, Hilary Shmeeda, Alberto Gabizon, Jerry Yeh
Publikováno v:
Clinical Cancer Research. 12:1913-1920
Purpose: A lipid-based prodrug of mitomycin C [MMC; 2,3-(distearoyloxy)propane-1-dithio-4′-benzyloxycarbonyl-MMC] was designed for liposome formulation. The purpose of this study was to examine the in vitro cytotoxicity, pharmacokinetics, in vivo t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed9bd5f0ad865db1ef11a103c469783
https://doi.org/10.1158/1078-0432.ccr-05-1547
https://doi.org/10.1158/1078-0432.ccr-05-1547
Publikováno v:
Advanced Drug Delivery Reviews. 56:1177-1192
Targeting of liposomes with phospholipid-anchored folate conjugates is an attractive approach to deliver chemotherapeutic agents to folate receptor (FR) expressing tumors. The use of polyethylene glycol (PEG)-coated liposomes with folate attached to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd67561297644f778fbc367b8bb07c31
https://doi.org/10.1016/j.addr.2004.01.011
https://doi.org/10.1016/j.addr.2004.01.011
Publikováno v:
Bioconjugate Chemistry. 14:563-574
Like most low molecular weight drugs, carboplatin has a short blood circulation time, which reduces tumor uptake and intracellular DNA binding. Drugs conjugated to PEG carriers benefit from prolonged blood circulation, but suffer from reduced cell pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bfa359cab28091a75cf2470ff55a17
https://doi.org/10.1021/bc025642l
https://doi.org/10.1021/bc025642l
Autor:
Dorit Goren, Dinah Tzemach, Aviva T. Horowitz, Alberto Gabizon, Alexander Lossos, Tali Siegal
Publikováno v:
Advanced Drug Delivery Reviews. 24:337-344
Inhibition of the rapid uptake of liposomes by the reticulo-endothelial system (RES) and reduction of the rate of drug leakage have resulted in long-circulating liposomal drug systems with valuable pharmacologic properties. Particularly, the coating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d680c88ec06a2a60c3025b298a9095
https://doi.org/10.1016/s0169-409x(96)00476-0
https://doi.org/10.1016/s0169-409x(96)00476-0
Publikováno v:
British Journal of Cancer
Long-circulating (stealth) liposomes coated with polyethylene glycol (PEG), which show reduced uptake by the reticuloendothelial system (RES) and enhanced accumulation in tumours, were used for conjugation to monoclonal antibodies (MAbs) as a drug-ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a53749a63092665307a4fc3e7c9ac8
http://europepmc.org/articles/PMC2077226
http://europepmc.org/articles/PMC2077226
Publikováno v:
Journal of Drug Targeting. 3:391-398
The effect of liposome composition on drug delivery to tumors and therapeutic efficacy of liposome-encapsulated anthracyclines was investigated in two murine tumor models: an ascitic tumor (J6456 lymphoma) and a solid carcinoma (M-109). Longevity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad21f44e4489e135b149d8bcd160cc3
https://doi.org/10.3109/10611869608996830
https://doi.org/10.3109/10611869608996830
Publikováno v:
Journal of Liposome Research. 3:517-528
Doxorubicin (DOX) has been encapsulated with high efficiency in the water phase of small-sized lipid vesicles. Plasma-induced drug leakage from these vesicles is minimal when hydrogenated phosphatidylcholine is present as the main component. A prolon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e15f19f298ae9b2cabc53aa2d88547
https://doi.org/10.3109/08982109309150734
https://doi.org/10.3109/08982109309150734
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1109:203-209
We have investigated the in vitro cytotoxicity of free doxorubicin (DOX) and liposome-entrapped DOX (L-DOX) against a human ovarian carcinoma cell line (OV-1063) using a colorimetric assay. DOX was encapsulated in the inner water phase of liposomes b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fac51e2a97f12d1afc6a8939db6cc4
https://doi.org/10.1016/0005-2736(92)90084-y
https://doi.org/10.1016/0005-2736(92)90084-y
Autor:
Miguel A. Fuertes, Alberto Gabizon, Dan Gibson, Aviva T. Horowitz, José M. Pérez, Olga Aronov
Publikováno v:
Bioconjugate chemistry. 15(4)
Carboplatin is a low-molecular-weight anticancer drug that acts by binding to the nuclear DNA of cells. Thus, efficient delivery of the platinum drugs to the nucleus of the cancer cells may enhance the cytotoxicity of the drug. Efficient drug deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cad9f76bc70e740d1f83e1c912c08f
https://pubmed.ncbi.nlm.nih.gov/15264869
https://pubmed.ncbi.nlm.nih.gov/15264869
Autor:
Alberto, Gabizon, Aviva T, Horowitz, Dorit, Goren, Dina, Tzemach, Hilary, Shmeeda, Samuel, Zalipsky
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(17)
To compare the in vivo tissue distribution of folate-targeted liposomes (FTLs) injected i.v. in mice bearing folate receptor (FR)-overexpressing tumors (mouse M109 and human KB carcinomas, and mouse J6456 lymphoma) to that of nontargeted liposomes (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c010cfdfc7536a982058110eac889764
https://pubmed.ncbi.nlm.nih.gov/14695160
https://pubmed.ncbi.nlm.nih.gov/14695160