Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Aviva M Tolkovsky"'
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31547 (2012)
We have previously shown that transplantation of immature DCX+/NeuN+/Prox1+ neurons (found in the neonatal DG), but not undifferentiated neuronal progenitor cells (NPCs) from ventral subventricular zone (SVZ), results in neuronal maturation in vivo w
Externí odkaz:
https://doaj.org/article/5e82e975964f4d11aadcdae849f1f46a
Publikováno v:
Neural Regeneration Research, Vol 10, Iss 11, Pp 1746-1747 (2015)
Externí odkaz:
https://doaj.org/article/3fe00dde38ed4fc4b8723c8c44b86d5d
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17072 (2011)
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical. We
Externí odkaz:
https://doaj.org/article/8bdb474edfdd447ab3bb75e7e990dd73
Autor:
Matthew Mason, Mehtap Bacioglu, Giorgio Vivacqua, Maria Grazia Spillantini, Aviva M Tolkovsky
Publikováno v:
The Lancet Neurology. 22:462-464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b7f2e21356a5ebc1ddc31930e3dc3b
https://doi.org/10.1016/s1474-4422(23)00108-4
https://doi.org/10.1016/s1474-4422(23)00108-4
Publikováno v:
Essays in Biochemistry
How neurons die in neurodegenerative diseases is still unknown. The distinction between apoptosis as a genetically controlled mechanism, and necrosis, which was viewed as an unregulated process, has blurred with the ever-increasing number of necrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220b93b288ae6a484b049082f7246ce5
https://doi.org/10.1042/ebc20210030
https://doi.org/10.1042/ebc20210030
Autor:
Bernardino Ghetti, William A. McEwan, Taxiarchis Katsinelos, Jack Brelstaff, Matthew J. Mason, Aviva M. Tolkovsky, Maria Grazia Spillantini
Publikováno v:
Science Advances
Description
Microglia change their behavior when eating live neurons containing tau protein aggregates, a hallmark of Alzheimer’s disease.
The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases, causing i
Microglia change their behavior when eating live neurons containing tau protein aggregates, a hallmark of Alzheimer’s disease.
The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases, causing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ae7a260f461367715795e16c066abe
https://doi.org/10.1126/sciadv.abg4980
https://doi.org/10.1126/sciadv.abg4980
Autor:
Jack Brelstaff, Bernardino Ghetti, Matthew J. Mason, Aviva M. Tolkovsky, Taxiarchis Katsinelos, William A. McEwan, Maria Grazia Spillantini
The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases, causing inflammation and changing the inflammatory signature of microglia by unknown mechanisms. We have shown that microglia phagocytose live neurons containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94ba3dddd0c347f15abefe3ed497180a
https://doi.org/10.1101/2021.02.26.433088
https://doi.org/10.1101/2021.02.26.433088
Autor:
Yanyan Zhao, Ole Tietz, Veronika Cubinkova, Norbert Žilka, Lindsay McMurray, Aviva M. Tolkovsky, Tomas Smolek, David W. Williamson, Jennifer A. Macdonald, Nisha K. Ramakrishnan, Michel Goedert, Xiaoyun Zhou, Steven G. Fagan, Franklin I. Aigbirhio, Steven Kealey, Maria Grazia Spillantini
Publikováno v:
ACS Chem. Neurosci.
ACS Chemical Neuroscience
ACS Chemical Neuroscience
Aggregated tau protein is a core pathology present in several neurodegenerative diseases. Therefore, the development and application of positron emission tomography (PET) imaging radiotracers that selectively bind to aggregated tau in fibril form is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d06b6ef04db1a6140b61714530ea0
Autor:
Hiroshi Ito, Maiko Ono, Ai Ishikawa, Makoto Higuchi, Aviva M. Tolkovsky, Naruhiko Sahara, Taketoshi Maehara, Takuya Urushihata, Hiroyuki Takuwa, Tetsuya Suhara, Virginia M.-Y. Lee, John Q. Trojanowski, Anna M. Barron, Hiroyasu Akatsu, Jun Maeda, Ming-Rong Zhang, Maria Grazia Spillantini, Bin Ji, Masafumi Shimojo, Yutaka Tomita, Manami Takahashi, Asumi Orihara, Kazuto Masamoto, Michel Goedert, Yuhei Takado
Fibrillary tau pathologies have been implicated in Alzheimer’s and allied neurodegenerative diseases, while mechanisms by which neurons bearing tau tangles die remain enigmatic. To address this issue, we pursued tau and related key pathologies macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75a1b5c0709b949952d0b10fc5a73165
https://doi.org/10.1101/2020.11.04.368977
https://doi.org/10.1101/2020.11.04.368977
Autor:
Linda Stöger, Yuan Ye, Ian D. Pavord, Janina Nahler, N Zeng, Chen Y-L., Jian Luo, W Liu, Aviva M. Tolkovsky, Rahul Shrimanker, Clare S. Hardman, Simei Go, Graham S. Ogg, L Reed, Yanqiu Wu, Paul Klenerman, Luzheng Xue
Publikováno v:
The Journal of Allergy and Clinical Immunology.
CAPSULE SUMMARY: Out of all type-2 immune cells, only ILC2s withstand corticosteroid treatment due to a reduced pro-apoptotic machinery. The findings may advance the understanding on the mechanism in steroid-resistant diseases and facilitate the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe5c51b63051ba8a592eb4c43aef611
http://ora.ox.ac.uk/objects/uuid:
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