Regulatory chromatin landscape in Arabidopsis thaliana roots uncovered by coupling INTACT and ATAC-seq

Autor: Miriam Tannenbaum, Avital Sarusi-Portuguez, Ronen Krispil, Michal Schwartz, Olga Loza, Jennifer I. C. Benichou, Assaf Mosquna, Ofir Hakim

Publikováno v: Plant Methods, Vol 14, Iss 1, Pp 1-12 (2018)

Abstract Background There is a growing interest in the role of chromatin in acquiring and maintaining cell identity. Despite the ever-growing availability of genome-wide gene expression data, understanding how transcription programs are established a

Externí odkaz: https://doaj.org/article/b8ac155cb1514c7294ff3d9535667f49

Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression

Autor: Avital Sarusi Portuguez, Ivana Grbesa, Moran Tal, Rachel Deitch, Dana Raz, Limor Kliker, Ran Weismann, Michal Schwartz, Olga Loza, Leslie Cohen, Libi Marchenkov-Flam, Myong-Hee Sung, Tommy Kaplan, Ofir Hakim

Publikováno v: Nucleic Acids Research. 50:6702-6714

The rapid transcriptional response to the transcription factor, glucocorticoid receptor (GR), including gene activation or repression, is mediated by the spatial association of genes with multiple GR binding sites (GBSs) over large genomic distances.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8601bedfa017e4e554077c0201d9d452
https://doi.org/10.1093/nar/gkac488

Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Autor: Elena Kotsiliti, Valentina Leone, Svenja Schuehle, Olivier Govaere, Hai Li, Monika J. Wolf, Helena Horvatic, Sandra Bierwirth, Jana Hundertmark, Donato Inverso, Laimdota Zizmare, Avital Sarusi-Portuguez, Revant Gupta, Tracy O’Connor, Anastasios D. Giannou, Ahmad Mustafa Shiri, Yehuda Schlesinger, Maria Garcia Beccaria, Charlotte Rennert, Dominik Pfister, Rupert Öllinger, Iana Gadjalova, Pierluigi Ramadori, Mohammad Rahbari, Nuh Rahbari, Marc Healy, Mirian Fernández-Vaquero, Neda Yahoo, Jakob Janzen, Indrabahadur Singh, Chaofan Fan, Xinyuan Liu, Monika Rau, Martin Feuchtenberger, Eva Schwaneck, Sebastian J. Wallace, Simon Cockell, John Wilson-Kanamori, Prakash Ramachandran, Celia Kho, Timothy J. Kendall, Anne-Laure Leblond, Selina J. Keppler, Piotr Bielecki, Katja Steiger, Maike Hofmann, Karsten Rippe, Horst Zitzlesberger, Achim Weber, Nisar Malek, Tom Lüdde, Mihael Vucur, Hellmut G. Augustin, Richard Flavell, Oren Parnas, Roland Rad, Olivier Pabst, Neil C. Henderson, Samuel Huber, Andrew Macpherson, Percy Knolle, Manfred Claasen, Andreas Geier, Christoph Trautwein, Kristian Unger, Eran Elinav, Ari Waisman, Zeinab Abdullah, Dirk Haller, Frank Tacke, Quentin M. Anstee, Mathias Heikenwalder

Publikováno v: Kotsiliti, E, Leone, V, Schuehle, S, Govaere, O, Li, H, Wolf, M J, Horvatic, H, Bierwirth, S, Hundertmark, J, Inverso, D, Zizmare, L, Sarusi-Portuguez, A, Gupta, R, O'Connor, T, Giannou, A D, Shiri, A M, Schlesinger, Y, Beccaria, M G, Rennert, C, Pfister, D, Öllinger, R, Gadjalova, I, Ramadori, P, Rahbari, M, Rahbari, N, Healy, M, Fernández-Vaquero, M, Yahoo, N, Janzen, J, Singh, I, Fan, C, Liu, X, Rau, M, Feuchtenberger, M, Schwaneck, E, Wallace, S J, Cockell, S, Wilson-Kanamori, J, Ramachandran, P, Kho, C, Kendall, T J, Leblond, A-L, Keppler, S J, Bielecki, P, Steiger, K, Hofmann, M, Rippe, K, Zitzlesberger, H, Weber, A, Malek, N, Lüdde, T, Vucur, M, Augustin, H G, Flavell, R, Parnas, O, Rad, R, Pabst, O, Henderson, N C, Huber, S, Macpherson, A, Knolle, P, Claasen, M, Geier, A, Trautwein, C, Unger, K, Elinav, E, Waisman, A, Abdullah, Z, Haller, D, Tacke, F, Anstee, Q M & Heikenwalder, M 2023, ' Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling ', Journal of Hepatology . https://doi.org/10.1016/j.jhep.2023.04.037

BACKGROUND & AIMS: The progression of nonalcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. The gut-liver axis contributes to NASH, but the mechanisms involved and the consequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e25f605ee9738f8f6026a70bbfe8ba

LY6S, a New Interferon-Inducible Human Member of the Ly6a-Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Autor: Moriya Shmerling, Michael Chalik, Nechama I. Smorodinsky, Alan Meeker, Sujayita Roy, Orit Sagi-Assif, Tsipi Meshel, Artem Danilevsky, Noam Shomron, Shmuel Levinger, Bar Nishry, David Baruchi, Avital Shargorodsky, Ravit Ziv, Avital Sarusi-Portuguez, Maoz Lahav, Marcelo Ehrlich, Bryony Braschi, Elspeth Bruford, Isaac P. Witz, Daniel H. Wreschner

Syntenic genomic loci on human chromosome 8 (hChr8) and mouse chromosome 15 (mChr15) code for LY6/Ly6 (lymphocyte antigen 6) family proteins. The 23 murine Ly6 family genes include eight genes that are flanked by the murine Ly6e and Ly6l genes and fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::477f97a0c4064d87ae2f115ee9e8564e
https://doi.org/10.1101/2021.12.16.472998

Regulatory chromatin landscape in Arabidopsis thaliana roots uncovered by coupling INTACT and ATAC-seq

Autor: Olga Loza, Miriam Tannenbaum, Ofir Hakim, Jennifer I. C. Benichou, Michal Schwartz, Ronen Krispil, Avital Sarusi-Portuguez, Assaf Mosquna

Publikováno v: Plant Methods, Vol 14, Iss 1, Pp 1-12 (2018)

Background There is a growing interest in the role of chromatin in acquiring and maintaining cell identity. Despite the ever-growing availability of genome-wide gene expression data, understanding how transcription programs are established and regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9a380e700379f45cf052de03ef74ed
http://link.springer.com/article/10.1186/s13007-018-0381-9