Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Avital Licht-Murava"'
Autor:
Samantha M. Meadows, Fernando Palaguachi, Minwoo Wendy Jang, Avital Licht-Murava, Daniel Barnett, Till S. Zimmer, Constance Zhou, Samantha R. McDonough, Adam L. Orr, Anna G. Orr
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114278- (2024)
Summary: Astrocytic receptors influence cognitive function and can promote behavioral deficits in disease. These effects may vary based on variables such as biological sex, but it is not known if the effects of astrocytic receptors are dependent on s
Externí odkaz:
https://doaj.org/article/b615039c5bc64967aff8c3199aa8fe35
Autor:
Avital Licht-Murava, Samantha M. Meadows, Fernando Palaguachi, Soomin C. Song, Stephanie Jackvony, Yaron Bram, Constance Zhou, Robert E. Schwartz, Robert C. Froemke, Adam L. Orr, Anna G. Orr
Publikováno v:
Science Advances. 9
TDP-43 pathology is prevalent in dementia but the cell type-specific effects of TDP-43 are not clear and therapeutic strategies to alleviate TDP-43-linked cognitive decline are lacking. We found that patients with Alzheimer’s disease (AD) or fronto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4654de151d53dbba6a35306eb4896912
https://doi.org/10.1126/sciadv.ade1282
https://doi.org/10.1126/sciadv.ade1282
Autor:
Samantha M. Meadows, Fernando Palaguachi, Avital Licht-Murava, Daniel Barnett, Till S. Zimmer, Constance Zhou, Samantha R. McDonough, Adam L. Orr, Anna G. Orr
Cognitive processes and neurocognitive disorders are regulated by astrocytes and have prominent sex differences. However, the contribution of astrocytes to sex differences is not known. We leveraged astrocyte-targeted gene editing and chemogenetics i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a944bc6d9fa8a471717b08f5074d1b
https://doi.org/10.1101/2022.11.03.511881
https://doi.org/10.1101/2022.11.03.511881
Autor:
Avital Licht Murava, Samantha Meadows, Fernando Palaguachi, Soomin C. Song, Yaron Bram, Constance Zhou, Robert E. Schwartz, Robert C. Froemke, Adam L. Orr, Anna G. Orr
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2105d205fc8a63ae355ebbeae3e306a
https://doi.org/10.1002/alz.058562
https://doi.org/10.1002/alz.058562
Autor:
Ari Robinson, Michal Schnaider Beeri, Sigal Liraz-Zaltsman, Avital Licht-Murava, Derek LeRoith, Dana Atrakchi-Baranes, Irit Lubitz, Pavel Katsel, Vahram Haroutunian
Publikováno v:
Journal of Molecular Neuroscience. 67:504-510
Disruption of brain insulin signaling may explain the higher Alzheimer's disease (AD) risk among type 2 diabetic (T2D) patients. There is evidence from in vitro and human postmortem studies that combination of insulin with hypoglycemic medications is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4929618824b985dccce6bd2b0315e328
https://doi.org/10.1007/s12031-019-1257-9
https://doi.org/10.1007/s12031-019-1257-9
Autor:
Batya Plotkin, Lilach Vaks, Limor Avrahami, Avital Licht-Murava, Miriam Eisenstein, Hagit Eldar-Finkelman, Rom Paz
Publikováno v:
Science Signaling. 9
Development of protein kinase inhibitors is a focus of many drug discovery programs. A major problem, however, is the limited specificity of the commonly used adenosine triphosphate-competitive inhibitors and the weak inhibition of the more selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15328b6eb2c971bf37fc059f6c253973
https://doi.org/10.1126/scisignal.aah7102
https://doi.org/10.1126/scisignal.aah7102
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:598-603
Glycogen synthase kinase-3 (GSK-3) is a highly conserved protein serine/threonine kinase ubiquitously distributed in eukaryotes as a constitutively active enzyme. Abnormally high GSK-3 activity has been implicated in several pathological disorders, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88224093bc183b061c09c80d0174f77e
https://doi.org/10.1016/j.bbapap.2009.09.010
https://doi.org/10.1016/j.bbapap.2009.09.010
Publikováno v:
Current pharmaceutical design. 18(20)
Protein kinases are potential targets of drugs to treat many human diseases. Intensive efforts have been made to develop protein kinase inhibitors, but a major challenge is achieving specificity. Exploiting regulatory elements outside the ATP binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe71ef6c1606fb57ad78ec13c051101b
https://pubmed.ncbi.nlm.nih.gov/22571660
https://pubmed.ncbi.nlm.nih.gov/22571660