Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Avinash S. Punekar"'
Autor:
Na Feng, Han Feng, Sheng Wang, Avinash S. Punekar, Rudolf Ladenstein, Da-Cheng Wang, Qinghua Zhang, Jingjin Ding, Wei Liu
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102951- (2021)
Summary: Heat shock factor 1 (HSF1) and 2 (HSF2) play distinct but overlapping regulatory roles in maintaining cellular proteostasis or mediating cell differentiation and development. Upon activation, both HSFs trimerize and bind to heat shock elemen
Externí odkaz:
https://doaj.org/article/8a612f7468c442f7a3987769bbc4a9ca
Autor:
Avinash S. Punekar, Firdaus Samsudin, Adrian J. Lloyd, Christopher G. Dowson, David J. Scott, Syma Khalid, David I. Roper
Publikováno v:
The Cell Surface, Vol 2, Iss , Pp 54-66 (2018)
Bacterial peptidoglycan glycosyltransferases (PGT) catalyse the essential polymerization of lipid II into linear glycan chains required for peptidoglycan biosynthesis. The PGT domain is composed of a large head subdomain and a smaller jaw subdomain a
Externí odkaz:
https://doaj.org/article/31c890c7d74f40edb5f000c832d21b84
Autor:
Han Feng, Sheng Wang, Ling Guo, Avinash S. Punekar, Rudolf Ladenstein, Da-Cheng Wang, Wei Liu
Publikováno v:
Protein & Cell, Vol 7, Iss 12, Pp 916-920 (2016)
Externí odkaz:
https://doaj.org/article/c0e3ced3b9794d79abc174ce08a4b894
Autor:
Sheng Wang, Rudolf Ladenstein, Wei Liu, Han Feng, Jingjin Ding, Avinash S. Punekar, Na Feng, Da-Cheng Wang, Qinghua Zhang
Publikováno v:
SSRN Electronic Journal.
Heat shock factor 1 (HSF1) and 2 (HSF2) play distinct but overlapping regulatory roles in maintaining cellular protein homeostasis or mediating cell differentiation anddevelopment. Upon activation, both HSFs trimerize and bind to heat shock elements(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfce0709fe14ee3dcb590c2e908ab95
https://doi.org/10.2139/ssrn.3787666
https://doi.org/10.2139/ssrn.3787666
Autor:
Anita C. Catherwood, Grzegorz P. Walkowiak, Avinash S. Punekar, Smita Chauhan, Christopher G. Dowson, David I. Roper, Dean Rea, Michael J. Chappell, Katie Smart, Neil D. Evans, Adrian J. Lloyd, Julie A. Tod, Nicola F. Galley, Susan E. Slade
Penicillin binding proteins (PBPs) catalyzing transpeptidation reactions that stabilize the peptidoglycan component of the bacterial cell wall are the targets of β-lactams, the most clinically successful antibiotics to date. However, PBP-transpeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff26a1aef173017304365c75380f3792
http://wrap.warwick.ac.uk/135299/1/WRAP-substrate-stereochemical-control-peptidoglycan-cross-linking-transpeptidation-Escherichia-coli-PBP1B-Dowson-2020.pdf
http://wrap.warwick.ac.uk/135299/1/WRAP-substrate-stereochemical-control-peptidoglycan-cross-linking-transpeptidation-Escherichia-coli-PBP1B-Dowson-2020.pdf
Autor:
Anita C, Catherwood, Adrian J, Lloyd, Julie A, Tod, Smita, Chauhan, Susan E, Slade, Grzegorz P, Walkowiak, Nicola F, Galley, Avinash S, Punekar, Katie, Smart, Dean, Rea, Neil D, Evans, Michael J, Chappell, David I, Roper, Christopher G, Dowson
Publikováno v:
Journal of the American Chemical Society. 142(11)
Penicillin binding proteins (PBPs) catalyzing transpeptidation reactions that stabilize the peptidoglycan component of the bacterial cell wall are the targets of β-lactams, the most clinically successful antibiotics to date. However, PBP-transpeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::198ab1837454f7e24c3868ce5bfbe6f7
https://pubmed.ncbi.nlm.nih.gov/32048840
https://pubmed.ncbi.nlm.nih.gov/32048840
Autor:
Marcus C. S. Lee, Edward Owen, James M. Murithi, Kerry McGowen, Beatriz Baragaña, Madeline R. Luth, Emma F. Carpenter, Jacquin C. Niles, Chris Walpole, Manu Vanaerschot, Rebecca E. K. Mandt, Sabine Ottilie, Ian H. Gilbert, Avinash S. Punekar, Charisse Flerida A. Pasaje, Krittikorn Kümpornsin, Aslı Akidil, João Pedro Pisco, Kelly Rubiano, Nimisha Mittal, David A. Fidock, Robert L. Summers, De Lin, Andy Plater, Sharon M. Shepherd, Elizabeth A. Winzeler, A. Hazel Dilmore, Andrew M. Shepherd, Amanda K. Lukens, Dyann F. Wirth, Madalyn Won, Josefine Striepen, Justin Munro, Manuel Llinás
Publikováno v:
Cell Chemical Biology. 29:191-201.e8
Summary We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e3028ee2d6c74bf0739d4ebecac7eb
https://doi.org/10.1016/j.chembiol.2021.07.010
https://doi.org/10.1016/j.chembiol.2021.07.010
Autor:
Qinghua Zhang, Avinash S. Punekar, Jingjin Ding, Rudolf Ladenstein, Han Feng, Da-Cheng Wang, Sheng Wang, Na Feng, Wei Liu
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102951-(2021)
iScience
iScience
Summary Heat shock factor 1 (HSF1) and 2 (HSF2) play distinct but overlapping regulatory roles in maintaining cellular proteostasis or mediating cell differentiation and development. Upon activation, both HSFs trimerize and bind to heat shock element
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c08e8e5d1044ebf569fb6eb0bf49336
https://doi.org/10.1016/j.isci.2021.102951
https://doi.org/10.1016/j.isci.2021.102951
Autor:
Avinash S. Punekar, Gemma Harris, David I. Roper, Dom Bellini, Colin W. G. Fishwick, Lloyd George Czaplewski, Ricky Cain, Adrian J. Lloyd, Ramya Salimaraj, Christopher G. Dowson, David J. Scott
Publikováno v:
Journal of medicinal chemistry. 62(21)
Aminoacyl-tRNA synthetases are ubiquitous and essential enzymes for protein synthesis and also a variety of other metabolic processes, especially in bacterial species. Bacterial aminoacyl-tRNA synthetases represent attractive and validated targets fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81589f98f550110899f53e40520bf9eb
https://pubmed.ncbi.nlm.nih.gov/31626547
https://pubmed.ncbi.nlm.nih.gov/31626547
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:417-426
MetR, a LysR-type transcriptional regulator (LTTR), has been extensively studied owing to its role in the control of methionine biosynthesis in proteobacteria. A MetR homodimer binds to a 24-base-pair operator region of themetgenes and specifically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b189223b44d81475cfbffa5428efd3c7
https://doi.org/10.1107/s2053230x16006828
https://doi.org/10.1107/s2053230x16006828