Výsledky vyhledávání - "Avinash Phadke"

Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity

Autor: Christopher W. Marlor, Milind Deshpande, Venkat Rao Gadhachanda, Kyle J. Eastman, Qiuping Wang, Jason Allan Wiles, Mingjun Huang, Dharaben Patel, Wengang Yang, Avinash Phadke

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:3463-3471

An unprecedented series of organometallic HCV (hepatitis C virus) NS5A (nonstructural 5A protein) replication complex inhibitors that incorporates a 1,1′-ferrocenediyl scaffold was explored. This scaffold introduces the elements of linear flexibili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5de95ba1d6ad573c6a24834dce027a
https://doi.org/10.1016/j.bmcl.2018.09.023

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ACH-806, an NS4A Antagonist, Inhibits Hepatitis C Virus Replication by Altering the Composition of Viral Replication Complexes

Autor: Xiangzhu Wang, Wengang Yang, Mingjun Huang, Milind Deshpande, Xiaohong Hou, Dawei Chen, Atul Agarwal, Joanne Fabrycki, Yongnian Sun, Avinash Phadke, Yongsen Zhao

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:3168-3177

Treatment of hepatitis C patients with direct-acting antiviral drugs involves the combination of multiple small-molecule inhibitors of distinctive mechanisms of action. ACH-806 (or GS-9132) is a novel, small-molecule inhibitor specific for hepatitis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f50224807cbff61c795b637830bf6d
https://doi.org/10.1128/aac.02630-12

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Selenophene-Containing Inhibitors of Type IIA Bacterial Topoisomerases

Autor: Michael J. Pucci, Jason Allan Wiles, Avinash Phadke, Jane A. Thanassi, Barton James Bradbury, Milind Deshpande

Publikováno v: Journal of Medicinal Chemistry. 54:3418-3425

We investigated compounds related to the previously reported antistaphyloccocal agent AVE6971 in an effort to attenuate inhibition of hERG potassium channel current that has been noted for this and related antibacterial drug classes. While most modif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea4e5cb74186ccadd8c1eb33d176992
https://doi.org/10.1021/jm2002124

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Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors

Autor: Mingjun Huang, Atul Agarwal, Avinash Phadke, Amy Sanchez, Xiaohong Hou, Wengang Yang, Milind Deshpande, Xingtie Nie, Joanne Fabrycki, Yongsen Zhao

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:2043-2052

We have discovered a novel class of compounds active against hepatitis C virus (HCV), using a surrogate cellular system, HCV replicon cells. The leading compound in the series, ACH-806 (GS-9132), is a potent and specific inhibitor of HCV. The selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5269514cf90b5adbf7489d413855609
https://doi.org/10.1128/aac.01548-07

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Small molecule inhibitors of E. coli primase, a novel bacterial target

Autor: Christy L. Thoma, Shirley Louise-May, Jason Allan Wiles, Atul Agarwal, Jane A. Thanassi, Cuixian Liu, Barton James Bradbury, David M. Nelson, Steven D. Podos, Milind Deshpande, Jijun Cheng, Michael J. Pucci, Avinash Phadke

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:2807-2810

Bacterial primase is essential for DNA replication in Gram-positive and Gram-negative bacteria. It is also structurally distinct from eukaryotic primases, and therefore an attractive, but under-explored, target for therapeutic intervention. We applie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785e13e3a89de5a0250bcb56dbcb38c8
https://doi.org/10.1016/j.bmcl.2007.02.056

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Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro

Autor: Wengang Yang, Yongnian Sun, Milind Deshpande, Avinash Phadke, Mingjun Huang

Publikováno v: Antimicrobial Agents and Chemotherapy. 51:338-342

Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690554220a662ca6cdc0a91ab0036601
https://doi.org/10.1128/aac.00498-06

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Synthesis of Well-Defined Tower-Shaped 1,3,5-Trisubstituted Adamantanes Incorporating a Macrocyclic Trilactam Ring System

Autor: Changshu Jin, Donald H. Lamunyon, Quan Li, Pavel A. Petukhov, Tatiana Zaikova, Avinash Phadke, John F. W. Keana, Aleksey V. Rukavishnikov, Melissa D. Lee

Publikováno v: The Journal of Organic Chemistry. 69:1010-1019

We describe the synthesis of two novel well-defined tower-shaped 1,3,5-trisubstituted adamantanes 30 and 33 that incorporate a macrocyclic trilactam ring system. Each nanoscale molecule has a broad tripodal base consisting of three identical sulfur-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5fc0c428e19904f977c4f1284a7e6aa
https://doi.org/10.1021/jo035640+

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