Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Avinash Muppidi"'
Autor:
Avinash Muppidi, Weijun Shen, Peter G. Schultz, Huafei Zou, Qiangwei Fu, Danling Wang, Elizabeth Chao, Peng-Yu Yang, Candy Lee, Xiaozhou Luo
Publikováno v:
Journal of Medicinal Chemistry. 61:3218-3223
Glucagon-like peptide 2 (GLP-2) is a hormone that has been shown to stimulate intestinal growth and attenuate intestinal inflammation. Despite being efficacious in a variety of animal models of disease, its therapeutic potential is hampered by the sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f9ff916e7b86d9c83032be05a1d658
https://doi.org/10.1021/acs.jmedchem.7b00768
https://doi.org/10.1021/acs.jmedchem.7b00768
Autor:
Qian Liu, Ruth E. Gimeno, Jason X. Tang, Gavin C. Barnard, Xilin Liu, Yong Du, Jorge Alsina-Fernandez, Paul J. Emmerson, Avinash Muppidi, Bei B Zhang, Richard Todd Pickard, Matthew J Hamang, Bei Shan, Tamer Coskun, Pamela Jean Mitchell, Malgorzata Donata Gonciarz, Kimberly K Ballman, John H. Sloan, Xinle Wu, Xudong Mao, Lisa A Foltz, Feng Wang, Dana Sindelar, Robert W. Siegel
Publikováno v:
Nature Medicine. 23:1215-1219
Growth/differentiation factor 15 (GDF15), also known as MIC-1, is a distant member of the transforming growth factor-β (TGF-β) superfamily and has been implicated in various biological functions, including cancer cachexia, renal and heart failure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2502200f39c5bdc1b589339efb20908a
https://doi.org/10.1038/nm.4393
https://doi.org/10.1038/nm.4393
Autor:
Elizabeth Chao, Ashley K. Woods, Elsa Pflimlin, Che-Hsiung Hsu, Avinash Muppidi, Madhupriya Mahankali, Andreas Crameri, Peng-Yu Yang, Huafei Zou, Danling Wang, Insha Ahmad, Sang Jun Lee, Weijun Shen, Candy Lee
Publikováno v:
Bioconjugate chemistry. 30(1)
Peptide hormone relaxin-2, a member of the insulin family of peptides, plays a key role in hemodynamics and renal function and has shown preclinical efficacy in multiple disease models, including acute heart failure, fibrosis, preeclampsia, and corne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc7a94ad2d1dd62b8d82ef0f9f293e7
https://pubmed.ncbi.nlm.nih.gov/30543420
https://pubmed.ncbi.nlm.nih.gov/30543420
Autor:
Elizabeth Chao, Vanessa Núñez, Lance Sherwood, Weijun Shen, Qing Lin, Peng-Yu Yang, Peter G. Schultz, Avinash Muppidi, Huafei Zou, Ashley K. Woods
Publikováno v:
ACS Chemical Biology. 11:324-328
Incretin-based peptides are effective therapeutics for treating type 2 diabetes mellitus (T2DM). Oxyntomodulin (OXM), a dual agonist of GLP-1R and GCGR, has shown superior weight loss and glucose lowering effects, compared to single GLP-1R agonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5402d38446e7ea7657fb1ef46734d92
https://doi.org/10.1021/acschembio.5b00787
https://doi.org/10.1021/acschembio.5b00787
Publikováno v:
Tetrahedron. 70:7740-7745
We report the synthesis of a series of distance-matching aryl and vinylaryl cross-linkers for constructing stapled peptides containing cysteines at i,i+7 positions. Langevin dynamics simulation studies helped to classify these cross-linkers into two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec1a6ee29db1bbd799619505883b23f
https://doi.org/10.1016/j.tet.2014.05.104
https://doi.org/10.1016/j.tet.2014.05.104
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1748-1751
Here we report the design and synthesis of a panel of stapled peptides containing a distance-matching biphenyl cross-linker based upon a peptide capsid assembly inhibitor reported previously. Compared with the linear peptide, the biphenyl-stapled pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f735969694353c66f9c251bf50314e9c
https://doi.org/10.1016/j.bmcl.2014.02.038
https://doi.org/10.1016/j.bmcl.2014.02.038
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1472-1475
We report the first application of a photoinduced 1,3-dipolar cycloaddition reaction to ‘staple’ a peptide dual inhibitor of the p53-Mdm2/Mdmx interactions. A series of stapled peptide inhibitors were efficiently synthesized and showed excellent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c7b1d0ad7a2d2507aa6e1a755a926f
https://doi.org/10.1016/j.bmcl.2011.01.004
https://doi.org/10.1016/j.bmcl.2011.01.004
Autor:
Avinash Muppidi, Thomas Szyperski, Kenichiro Doi, Surya V.S.R.K. Pulavarti, Selvakumar Edwardraja, Hong Gang Wang, Qing Lin
Publikováno v:
Bioconjugate Chemistry
BH3 peptides are key mediators of apoptosis and have served as the lead structures for the development of anticancer therapeutics. Previously, we reported the application of a simple cysteine-based side chain cross-linking chemistry to NoxaBH3 peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e943a81b6ad2a57bd7c748f43ec610d
https://pubmed.ncbi.nlm.nih.gov/24410055
https://pubmed.ncbi.nlm.nih.gov/24410055
Autor:
Hong Gang Wang, Qing Lin, Avinash Muppidi, Eric J. Drake, Kenichiro Doi, Andrew M. Gulick, Selvakumar Edwardraja
Direct chemical modifications of helical peptides have provided a simple and effective means to ‘translate’ the bioactive helical peptides into potential therapeutics targeting intracellular protein-protein interactions. Previously, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7a9ff1c1b0950ba39b0320924c93b8
https://europepmc.org/articles/PMC3472523/
https://europepmc.org/articles/PMC3472523/
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(24)
We report the first synthesis of the C-terminally spermine-conjugated stapled peptide-based inhibitors of the p53-Mdm2 interaction. Subsequent biological, biophysical and cellular uptake assays with the spermine-conjugated stapled peptides revealed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823ff80083a0cf95e4d2e827d92fdb31
https://pubmed.ncbi.nlm.nih.gov/22047690
https://pubmed.ncbi.nlm.nih.gov/22047690