Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Avinash K Persaud"'
Autor:
Melissa Thomas, Junan Li, Kevan King, Avinash K Persaud, Ernest Duah, Zachary Vangundy, Craig C. Hofmeister, Jatinder K. Lamba, Aik Choon Tan, Brooke L. Fridley, Ming J. Poi, Nathan D. Seligson
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
Multiple Myeloma (MM) is an incurable plasma cell malignancy often treated by autologous stem cell transplant (ASCT). Clinical response to ASCT has been associated with DNA repair efficiency. Here we interrogated the role of the base excision DNA rep
Externí odkaz:
https://doaj.org/article/7a7b8d3edef349908f93a513689d97de
Autor:
Debasis Nayak, Brenna Weadick, Avinash K. Persaud, Radhika Raj, Reena Shakya, Junan Li, Moray J. Campbell, Rajgopal Govindarajan
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104193- (2022)
Summary: The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells
Externí odkaz:
https://doaj.org/article/7f4a4a2d3e4b42b5a8bce96353c443e8
Autor:
Avinash K. Persaud, Sreenath Nair, Md Fazlur Rahman, Radhika Raj, Brenna Weadick, Debasis Nayak, Craig McElroy, Muruganandan Shanmugam, Sue Knoblaugh, Xiaolin Cheng, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid tr
Externí odkaz:
https://doaj.org/article/087a41082d3d4e2c8dbfb1af03cf1a8b
Autor:
Ji Young Kim, Yuntao Bai, Laura A. Jayne, Ralph D. Hector, Avinash K. Persaud, Su Sien Ong, Shreshtha Rojesh, Radhika Raj, Mei Ji He Ho Feng, Sangwoon Chung, Rachel E. Cianciolo, John W. Christman, Moray J. Campbell, David S. Gardner, Sharyn D. Baker, Alex Sparreboom, Rajgopal Govindarajan, Harpreet Singh, Taosheng Chen, Ming Poi, Katalin Susztak, Stuart R. Cobb, Navjot Singh Pabla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a S
Externí odkaz:
https://doaj.org/article/f36413dcdc0f4c47bbdac00ac1a34b20
Autor:
Sreenath Nair, Anne M. Strohecker, Avinash K. Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig McElroy, Rakesh Pathak, Michelle Williams, Radhika Raj, Amal Kaddoumi, Alex Sparreboom, Aaron M. Beedle, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misreg
Externí odkaz:
https://doaj.org/article/808693518ee945b095baa8826e112354
Autor:
Syed Saqib Ali, Ruchika Raj, Tejinder Kaur, Brenna Weadick, Debasis Nayak, Minnsung No, Jane Protos, Hannah Odom, Kajal Desai, Avinash K. Persaud, Joanne Wang, Rajgopal Govindarajan
Publikováno v:
Cancers, Vol 14, Iss 13, p 3113 (2022)
Anticancer nucleoside analogs produce adverse, and at times, dose-limiting hematological toxicities that can compromise treatment efficacy, yet the mechanisms of such toxicities are poorly understood. Recently, cellular nucleoside transport has been
Externí odkaz:
https://doaj.org/article/8ce329d569a54bfdabbdf845457f9b69
Autor:
Ernest Duah, Nathan D. Seligson, Avinash K. Persaud, Quynh Dam, Navjot Pabla, James W. Rocco, Junan Li, Ming Poi
Publikováno v:
Molecular Carcinogenesis.
Autor:
Rajgopal Govindarajan, Terence M. Williams, Junan Li, Wei Chen, Moray J. Campbell, Radhika Raj, Sau Wai Hung, Avinash K. Persaud, Debasis Nayak, Brenna Weadick
Video 3. N+/E- cells 3D reconstruction animation shows localization of ENT1 (red) and DAPI (blue)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf686e33a6623683c8105cd18b1913c6
https://doi.org/10.1158/1535-7163.22521970
https://doi.org/10.1158/1535-7163.22521970
Autor:
Rajgopal Govindarajan, Terence M. Williams, Junan Li, Wei Chen, Moray J. Campbell, Radhika Raj, Sau Wai Hung, Avinash K. Persaud, Debasis Nayak, Brenna Weadick
Epithelial–mesenchymal transition (EMT) in cancer cells drives cancer chemoresistance, yet the molecular events of EMT that underpin the acquisition of chemoresistance are poorly understood. Here, we demonstrate a loss of gemcitabine chemosensitivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbc845d30d739b87ad152b1d44becc4
https://doi.org/10.1158/1535-7163.c.6543235.v1
https://doi.org/10.1158/1535-7163.c.6543235.v1
Autor:
Rajgopal Govindarajan, Terence M. Williams, Junan Li, Wei Chen, Moray J. Campbell, Radhika Raj, Sau Wai Hung, Avinash K. Persaud, Debasis Nayak, Brenna Weadick
Video 2. Animation displays 3D reconstruction of PANC-1 cells grown in monolayer immunostained for ENT1 (red) and DAPI (blue)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2177a0cd4a7efb54d211852e14700385
https://doi.org/10.1158/1535-7163.22521976
https://doi.org/10.1158/1535-7163.22521976