Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Avinash Bhandoola"'
Autor:
Wei Yang, Rafi Ahmed, Jay Shendure, Kenneth Ng, Rajesh Valanparambil, Allan Wang, Kathleen Abadie, Elisa C Clark, Obinna Ukogu, Riza Daza, Jumana Fathima, Avinash Bhandoola, Hao Nourmohammad, Junyue Cao, Hao Yuan Kueh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/06a68574a0604923b8b5eeccc0500dc4
Autor:
Mingzhu Zheng, Chen Yao, Gang Ren, Kairui Mao, Hyunwoo Chung, Xi Chen, Gangqing Hu, Lei Wang, Xuemei Luan, Difeng Fang, Dan Li, Chao Zhong, Xiaoxiao Lu, Nikki Cannon, Mingxu Zhang, Avinash Bhandoola, Keji Zhao, John J. O’Shea, Jinfang Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112924- (2023)
Summary: Lymphoid tissue inducer (LTi) cells, a subset of innate lymphoid cells (ILCs), play an essential role in the formation of secondary lymphoid tissues. However, the regulation of the development and functions of this ILC subset is still elusiv
Externí odkaz:
https://doaj.org/article/4cb729c112134e7699da22a5b22d9952
Autor:
Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-depende
Externí odkaz:
https://doaj.org/article/784327815c984356aac217a9fbd2ed1e
Autor:
Phuong T. Le, Ngoc Ha, Ngan K. Tran, Andrew G. Newman, Katharine M. Esselen, John L. Dalrymple, Eva M. Schmelz, Avinash Bhandoola, Hai-Hui Xue, Prim B. Singh, To-Ha Thai
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune checkpoint blockade (ICB) relieves CD8+ T-cell exhaustion in most mutated tumors, and TCF-1 is implicated in converting progenitor exhausted cells to functional effector cells. However, identifying mechanisms that can prevent functional senesc
Externí odkaz:
https://doaj.org/article/5046e0f6247a45a98a6ec88b1cfc1444
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ecto
Externí odkaz:
https://doaj.org/article/c993fea9a7bb4a5ead83c786d4468663
Autor:
Christelle Harly, Devin Kenney, Yueqiang Wang, Yi Ding, Yongge Zhao, Parirokh Awasthi, Avinash Bhandoola
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendrit
Externí odkaz:
https://doaj.org/article/20d655e96b02401380accce2ff042d76
Autor:
Lauren A Richardson, Sandra L Schmid, Avinash Bhandoola, Christelle Harly, Anders Hedenström, Michael T Laub, Georgina M Mace, Piali Sengupta, Ann M Stock, Andrew F Read, Harmit S Malik, Mark Estelle, Sally Lowell, Jonathan Kimmelman
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000180 (2019)
Externí odkaz:
https://doaj.org/article/fa32077ec61c4145bffd2f19ee04d3af
Autor:
Wen-Hsuan W. Lin, Simone A. Nish, Bonnie Yen, Yen-Hua Chen, William C. Adams, Radomir Kratchmarov, Nyanza J. Rothman, Avinash Bhandoola, Hai-Hui Xue, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1773-1782 (2016)
Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this r
Externí odkaz:
https://doaj.org/article/15543fb84dbf457b819749ecac5306c8
Autor:
Meredith H Shaffer, Yanping Huang, Evann Corbo, Gregory F Wu, Marielena Velez, John K Choi, Ichiko Saotome, Judy L Cannon, Andrea I McClatchey, Anne I Sperling, Jonathan S Maltzman, Paula M Oliver, Avinash Bhandoola, Terri M Laufer, Janis K Burkhardt
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12404 (2010)
Ezrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling and pol
Externí odkaz:
https://doaj.org/article/56ce580815234058a88d288fe69bec5a
Autor:
Yuanyue Zhang, Jacob T. Bailey, En Xu, Kunal Singh, Marieke Lavaert, Verena M. Link, Shanti D’Souza, Alex Hafiz, Jian Cao, Gaoyuan Cao, Derek B. Sant’Angelo, Wei Sun, Yasmine Belkaid, Avinash Bhandoola, Dorian B. McGavern, Qi Yang
Publikováno v:
Nature Immunology. 23:1714-1725
Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain. However, the specific mechanisms by which immune cells promote normal neural function are not enti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb960b8f0dcfe1aa321ed3f7246f414
https://doi.org/10.1038/s41590-022-01349-1
https://doi.org/10.1038/s41590-022-01349-1