Stephalagine, an aporphine alkaloid from Annona crassiflora fruit peel, induces antinociceptive effects by TRPA1 and TRPV1 channels modulation in mice.

Autor: Justino AB; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Barbosa MF; Graduate Program in Chemistry, Institute of Chemistry, Federal University of Uberlândia, 38400-902 Uberlândia, MG, Brazil., Neves TV; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Silva HCG; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Brum EDS; Graduate Program in Biological Sciences: Toxicological Biochemistry, Biochemistry and Molecular Biology Department, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil., Fialho MFP; Graduate Program in Biological Sciences: Toxicological Biochemistry, Biochemistry and Molecular Biology Department, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil., Couto AC; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Saraiva AL; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Avila VMR; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Oliveira SM; Graduate Program in Biological Sciences: Toxicological Biochemistry, Biochemistry and Molecular Biology Department, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil., Pivatto M; Graduate Program in Chemistry, Institute of Chemistry, Federal University of Uberlândia, 38400-902 Uberlândia, MG, Brazil., Espindola FS; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil., Silva CR; Graduate Program in Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, 38408-100 Uberlândia, MG, Brazil. Electronic address: cassia.regina@ufu.br.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Mar; Vol. 96, pp. 103562. Date of Electronic Publication: 2020 Jan 16.