Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

Autor: Jiwaji Z; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Tiwari SS; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Avilés-Reyes RX; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., Hooley M; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Hampton D; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Torvell M; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK.; UK Dementia Research Institute at Cardiff University, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Johnson DA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., McQueen J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Baxter P; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Sabari-Sankar K; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., Qiu J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., He X; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Fowler J; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Febery J; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Gregory J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Rose J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Tulloch J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Loan J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Story D; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., McDade K; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK., Smith AM; UK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK., Greer P; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Ball M; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Kind PC; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Matthews PM; UK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK., Smith C; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Dando O; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Spires-Jones TL; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Johnson JA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA. jeffrey.johnson@wisc.edu., Chandran S; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK. Siddharthan.Chandran@ed.ac.uk.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK. Siddharthan.Chandran@ed.ac.uk., Hardingham GE; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK. Giles.Hardingham@ed.ac.uk.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Giles.Hardingham@ed.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Jan 10; Vol. 13 (1), pp. 135. Date of Electronic Publication: 2022 Jan 10.

The proinflammatory RAGE/NF-κB pathway is involved in neuronal damage and reactive gliosis in a model of sleep apnea by intermittent hypoxia.

Autor: Angelo MF; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Aguirre A; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Avilés Reyes RX; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Villarreal A; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Lukin J; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Melendez M; Centre Internationale de Recherche en Infectiologie, INSERM U1111, CNRS UMR5038, Ecole Normale Supérieure, Université Lyon 1, Lyon, France., Vanasco V; Instituto de Bioquímica y Medicina Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Barker P; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Alvarez S; Instituto de Bioquímica y Medicina Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Epstein A; Centre Internationale de Recherche en Infectiologie, INSERM U1111, CNRS UMR5038, Ecole Normale Supérieure, Université Lyon 1, Lyon, France., Jerusalinsky D; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina., Ramos AJ; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina.

Publikováno v: PloS one [PLoS One] 2014 Sep 29; Vol. 9 (9), pp. e107901. Date of Electronic Publication: 2014 Sep 29 (Print Publication: 2014).