Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Avigail T. Erlich"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract p53 plays an important role in regulating mitochondrial homeostasis. However, it is unknown whether p53 is required for the physiological and mitochondrial adaptations with exercise training. Furthermore, it is also unknown whether impairmen
Externí odkaz:
https://doaj.org/article/3ad846f326be4a85b266e7e44af0066c
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background Parkin is a ubiquitin ligase that is involved in the selective removal of dysfunctional mitochondria. This process is termed mitophagy and can assist in mitochondrial quality control. Endurance training can produce adaptations in
Externí odkaz:
https://doaj.org/article/cdffa4e4c36447c89584e3e85c17295b
Autor:
Avigail T. Erlich, Liam D. Tryon, Matthew J. Crilly, Jonathan M. Memme, Zahra S. Mesbah Moosavi, Ashley N. Oliveira, Kaitlyn Beyfuss, David A. Hood
Publikováno v:
Integrative Medicine Research, Vol 5, Iss 3, Pp 187-197 (2016)
Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in
Externí odkaz:
https://doaj.org/article/d17e2bd310dd4084832f10b56220007d
Autor:
Avigail T. Erlich, David A. Hood
Publikováno v:
Journal of Science in Sport and Exercise. 1:228-236
Mitochondria are essential energy-providing organelles that are required in the maintenance of healthy skeletal muscle. As such, the removal of damaged mitochondria, through mitophagy, is necessary to maintain mitochondrial quality. In aging muscle,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92828345ed32c86f2739566bd843f803
https://doi.org/10.1007/s42978-019-00041-5
https://doi.org/10.1007/s42978-019-00041-5
Autor:
Madeleine Deschenes, Nicholas Preobrazenski, Andrew Ma, Hashim Islam, Joe Quadrilatero, Jacob T. Bonafiglia, Brendon J. Gurd, Avigail T. Erlich, David A. Hood
NEW FINDINGS What is the central question of the study? Do interindividual differences in trainability exist for morphological and molecular skeletal muscle responses to aerobic exercise training? What is the main finding and its importance? Interind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913c8c3832f39b5f9c8235eeaae3eb24
https://hdl.handle.net/1974/29425
https://hdl.handle.net/1974/29425
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 471:431-440
Autophagy and mitophagy are important for training-inducible muscle adaptations, yet it remains unclear how these systems are regulated throughout the adaptation process. Here, we studied autophagic and mitophagic flux in the skeletal muscles of Spra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caba3860f4428cd1163f326aa76212a1
https://doi.org/10.1007/s00424-018-2225-x
https://doi.org/10.1007/s00424-018-2225-x
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 315:E404-E415
The maintenance of muscle health with advancing age is dependent on mitochondrial homeostasis. While reductions in mitochondrial biogenesis have been observed with age, less is known regarding organelle degradation. Parkin is an E3 ubiquitin ligase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647d426428291d2f1abbaae6885d444d
https://doi.org/10.1152/ajpendo.00391.2017
https://doi.org/10.1152/ajpendo.00391.2017
Publikováno v:
The Journal of Physiology. 596:3567-3584
Key points A healthy mitochondrial pool is dependent on the removal of dysfunctional organelles via mitophagy, but little is known about how mitophagy is altered with ageing and chronic exercise. Chronic contractile activity (CCA) is a standardized e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39fcc33d1184098953f8e55289f03c62
https://doi.org/10.1113/jp275998
https://doi.org/10.1113/jp275998
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C62-C72
The mitochondrial network in muscle is controlled by the opposing processes of mitochondrial biogenesis and mitophagy. The coactivator peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) regulates biogenesis, while the transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeef0464729a04415859979682c72343
https://doi.org/10.1152/ajpcell.00162.2017
https://doi.org/10.1152/ajpcell.00162.2017
Publikováno v:
The Journal of physiologyReferences. 599(3)
Mitochondrial health is an important mediator of cellular function across a range of tissues, and as a result contributes to whole-body vitality in health and disease. Our understanding of the regulation and function of these organelles is of great i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db4df87b7f091d2be705e0df90c93b0
https://pubmed.ncbi.nlm.nih.gov/31674658
https://pubmed.ncbi.nlm.nih.gov/31674658