Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Avigail Rein"'
Autor:
Eitan Kugler, Shreyas Madiwale, Darren Yong, Julie A. I. Thoms, Yehudit Birger, David B. Sykes, Johannes Schmoellerl, Aneta Drakul, Valdemar Priebe, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Heather Ogana, Elisabeth Liedke, Jean-Pierre Bourquin, Johannes Zuber, Michael Milyavsky, John Pimanda, Gilbert G. Privé, Shai Izraeli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors contributing to leukemogenesis are poorly understood. Drug targeting a transcription f
Externí odkaz:
https://doaj.org/article/d7035b0bdc8b4304be06aaa591c4d83a
Autor:
Avigail Rein, Ifat Geron, Eitan Kugler, Hila Fishman, Eyal Gottlieb, Ifat Abramovich, Amir Giladi, Ido Amit, Roger Mulet-Lazaro, Ruud Delwel, Stefan Gröschel, Smadar Levin-Zaidman, Nili Dezorella, Vered Holdengreber, Tata Nageswara Rao, Joanne Yacobovich, Orna Steinberg-Shemer, Qiu-Hua Huang, Yun Tan, Sai-Juan Chen, Shai Izraeli, Yehudit Birger
Publikováno v:
Haematologica, Vol 108, Iss 9 (2022)
Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85% of carriers. How a partial loss of GATA2 functionality
Externí odkaz:
https://doaj.org/article/1db36de967424a0ab5c3963d61088f52
Autor:
Ifat Geron, Angela Maria Savino, Hila Fishman, Noa Tal, John Brown, Virginia A. Turati, Chela James, Jolanda Sarno, Michal Hameiri-Grossman, Yu Nee Lee, Avigail Rein, Hillary Maniriho, Yehudit Birger, Anna Zemlyansky, Inna Muler, Kara L. Davis, Victoria Marcu-Malina, Nicole Mattson, Oren Parnas, Rabea Wagener, Ute Fischer, João T. Barata, Catriona H. M. Jamieson, Markus Müschen, Chun-Wei Chen, Arndt Borkhardt, Ilan Richard Kirsch, Arnon Nagler, Tariq Enver, Shai Izraeli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Activating mutations in Interleukin-7 receptor alpha (IL7Ra) have been reported in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) but its role in leukaemogenesis is not clear. Here, the authors show that activation of IL7Ra in primary human
Externí odkaz:
https://doaj.org/article/38d90d34ce264d24b343a4ddcc158487
Autor:
Ya-Kai Fu, Yun Tan, Bo Wu, Yu-Ting Dai, Xiao-Guang Xu, Meng-Meng Pan, Zhi-Wei Chen, Niu Qiao, Jing Wu, Lu Jiang, Jing Lu, Bing Chen, Avigail Rein, Shai Izraeli, Xiao-Jian Sun, Jin-Yan Huang, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Abstract GATA2, a key transcription factor in hematopoiesis, is frequently mutated in hematopoietic malignancies. How the GATA2 mutants contribute to hematopoiesis and malignant transformation remains largely unexplored. Here, we report that Gata2-L3
Externí odkaz:
https://doaj.org/article/070f84f5a9a041eb8a6fce56b49ec3ee
Autor:
Eitan Kugler, Shreyas Madiwale, Darren Yong, Yehudit Birger, Julie AI Thoms, David B Sykes, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Michael Milyavsky, John Pimanda, Gilbert G Privé, Shai Izraeli
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S215-S216
Autor:
Eitan Kugler, Shreyas Madiwale, Darren Yong, Yehudit Birger, Julie Thoms, David Sykes, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Michael Milyavsky, John Pimanda, Gilbert Privé, Shai Izraeli
The ETS transcription factor ERG is involved in several cancers including leukemias. We and others have demonstrated a direct role for ERG in leukemia initiation and maintenance of several subtypes of myeloid and lymphoid leukemias. However, ERG doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed0246fccc765f49a40b4c85c49c541e
https://doi.org/10.21203/rs.3.rs-1426447/v1
https://doi.org/10.21203/rs.3.rs-1426447/v1
Autor:
Eitan Kugler, Shreyas Madiwale, Darren Yong, Yehudit Birger, Julie AI Thoms, David B Sykes, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Michael Milyavsky, John Pimanda, Gilbert G Privé, Shai Izraeli
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S129
Autor:
Pieter Van Vlierberghe, Vase Bari, Shai Izraeli, Ginette Schiby, Shreyas Madiwale, Adolfo A. Ferrando, Eitan Kugler, Ifat Geron, Sabine Strehl, James C. Mulloy, Gilgi Friedlander, Hila Fishman, Birgit Knoechel, Jean Soulier, Arnon Nagler, Wouter Van Loocke, Yehudit Birger, Itamar Ganmore, Yael Kirschenbaum, Avigail Rein-Gil, Sharon Noy Lotan
Publikováno v:
Blood
Mixed-phenotype acute leukemia is a rare subtype of leukemia in which both myeloid and lymphoid markers are co-expressed on the same malignant cells. The pathogenesis is largely unknown, and the treatment is challenging. We previously reported the sp
Autor:
Virginia Turati, Noa Tal, Shai Izraeli, Arndt Borkhardt, Ilan R. Kirsch, Kara L. Davis, Yu Nee Lee, Arnon Nagler, Markus Müschen, John W. S. Brown, Inna Muler, Oren Parnas, Angela Maria Savino, Avigail Rein Gil, Tariq Enver, Jolanda Sarno, Ute Fischer, Ifat Geron, Yehudit Birger, Hila Fishman, Victoria Marcu-Malina, Michal Hameiri-Grossman, Chela James
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is preceded by a clinically silent pre-leukemia. Experimental models that authentically re-capitulate disease initiation and progression in human cells are lacking. We previously described activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea298ddaeeb2daefc2c7c2a58f31e09
Autor:
Hiral Patel, Jacek Sikora, Te Ling, Yehudit Birger, Chunling Fu, Eitan Kugler, Wei Chen, Neil L. Kelleher, Avigail Rein, John D. Crispino, Young Ah Goo, Lihua Zou, Tomer Kalisky, Monika J. Stankiewicz, Shai Izraeli, Kevin Zhang, Nissim Ben-Haim
Publikováno v:
Blood
Mutations in GATA1, which lead to expression of the GATA1s isoform that lacks the GATA1 N terminus, are seen in patients with Diamond-Blackfan anemia (DBA). In our efforts to better understand the connection between GATA1s and DBA, we comprehensively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9073645a574ee4570c8999aeda6a38
https://europepmc.org/articles/PMC6871310/
https://europepmc.org/articles/PMC6871310/