Elusive copy number variation in the mouse genome.

Autor: Avigail Agam, Binnaz Yalcin, Amarjit Bhomra, Matthew Cubin, Caleb Webber, Christopher Holmes, Jonathan Flint, Richard Mott

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12839 (2010)

Array comparative genomic hybridization (aCGH) to detect copy number variants (CNVs) in mammalian genomes has led to a growing awareness of the potential importance of this category of sequence variation as a cause of phenotypic variation. Yet there

Externí odkaz: https://doaj.org/article/8e7712a66c8a497facc3a86bcb072c55

Mouse genomic variation and its effect on phenotypes and gene regulation

Autor: Richard Mott, Sendu Bala, Richard Durbin, Christoffer Nellåker, Wei Yuan, Bret A. Payseur, José Afonso Guerra-Assunção, Polinka Hernandez-Pliego, Leah Rae Donahue, Deborah Janowitz, Nick Furlotte, Kim Wong, Rebecca E. McIntyre, Guy Slater, Jérôme Nicod, Thomas M. Keane, Eleazar Eskin, David J. Adams, L van der Weyden, Andrew Edwards, Charles A. Steward, Chris P. Ponting, Xiangchao Gan, Michael A. White, T G Belgard, Amarjit Bhomra, Leo Goodstadt, Ian J. Jackson, Laura G. Reinholdt, Petr Danecek, Jonathan Flint, Martin Goodson, Jim Stalker, Anne Czechanski, Helen Whitley, Peter L. Oliver, Binnaz Yalcin, Ewan Birney, Andreas Heger, Avigail Agam, James Cleak

Publikováno v: Keane, T M, Goodstadt, L, Danecek, P, White, M A, Wong, K, Yalcin, B, Heger, A, Agam, A, Slater, G, Goodson, M, Furlotte, N A, Eskin, E, Nellåker, C, Whitley, H, Cleak, J, Janowitz, D, Hernandez-Pliego, P, Edwards, A, Belgard, T G, Oliver, P L, McIntyre, R E, Bhomra, A, Nicod, J, Gan, X, Yuan, W, van der Weyden, L, Steward, C A, Bala, S, Stalker, J, Mott, R, Durbin, R, Jackson, I J, Czechanski, A, Guerra-Assunção, J A, Donahue, L R, Reinholdt, L G, Payseur, B A, Ponting, C, Birney, E, Flint, J & Adams, D J 2011, ' Mouse genomic variation and its effect on phenotypes and gene regulation ', Nature, vol. 477, no. 7364, pp. 289-94 . https://doi.org/10.1038/nature10413
Nature
Nature, 2011, 477, pp.289-294. ⟨10.1038/nature10413⟩

International audience; We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944974cc022f1c2a6f0ede67b991c981
https://doi.org/10.1038/nature10413

Sequence-based characterization of structural variation in the mouse genome

Autor: Richard Mott, James Cleak, Deborah Janowitz, Jérôme Nicod, Thomas M. Keane, Helen Whitley, David J. Adams, Amarjit Bhomra, Christoffer Nellåker, Binnaz Yalcin, Martin Goodson, Rebekah Dutton, Kim Wong, Leo Goodstadt, Jonathan Flint, Avigail Agam, Polinka Hernandez-Pliego, Xiangchao Gan

Publikováno v: Nature
Nature, 2011, 477, pp.326-329. ⟨10.1038/nature10432⟩

International audience; Structural variation is widespread in mammalian genomes and is an important cause of disease, but just how abundant and important structural variants (SVs) are in shaping phenotypic variation remains unclear. Without knowing h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473e0f3d5f7d40a8341781e9af8735a2
http://ora.ox.ac.uk/objects/uuid:dbdf3897-0d83-4aa2-834d-2c8fcd76b420