Development of Biotinylated Liposomes Encapsulating Metformin for Therapeutic Targeting of Inflammation-Based Diseases

Autor: Giorgia Ailuno, Sara Baldassari, Alice Balboni, Sara Pastorino, Guendalina Zuccari, Katia Cortese, Federica Barbieri, Giuliana Drava, Tullio Florio, Gabriele Caviglioli

Publikováno v: Pharmaceutics, Vol 16, Iss 2, p 235 (2024)

Inflammation is a physiological response to a damaging stimulus but sometimes can be the cause of the onset of neurodegenerative diseases, atherosclerosis, and cancer. These pathologies are characterized by the overexpression of inflammatory markers

Externí odkaz: https://doaj.org/article/978b5bcf67624eed9e5e8db6b203a7c8

The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype

Autor: Eva Krkavcová, Jakub Kreisinger, Ludmila Hyánková, Pavel Hyršl, Veronika Javůrková

Publikováno v: Biology Open, Vol 7, Iss 4 (2018)

Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is assumed to have a pronounced, though still poorly explored, effect on hatchling phenotype. We teste

Externí odkaz: https://doaj.org/article/d04418e5336b4dfe9f7179287af8c3e7

Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting

Autor: Cecilia Marini, Vanessa Cossu, Giorgia Ailuno, Sara Baldassari, Tullio Florio, Silvana Alfei, Gabriele Caviglioli, Sara Pastorino, Gianmario Sambuceti, Guendalina Zuccari, Giuliana Drava, Andrea Petretto

Publikováno v: Pharmaceutics
Volume 13
Issue 7
Pharmaceutics 13 (2021): 1025. doi:10.3390/pharmaceutics13071025
info:cnr-pdr/source/autori:Pastorino S.; Baldassari S.; Ailuno G.; Zuccari G.; Drava G.; Petretto A.; Cossu V.; Marini C.; Alfei S.; Florio T.; Sambuceti G.; Caviglioli G./titolo:Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting/doi:10.3390%2Fpharmaceutics13071025/rivista:Pharmaceutics/anno:2021/pagina_da:1025/pagina_a:/intervallo_pagine:1025/volume:13
Pharmaceutics, Vol 13, Iss 1025, p 1025 (2021)

Atherosclerosis is a chronic progressive disease involving inflammatory events, such as the overexpression of adhesion molecules including the endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1). VCAM-1 is rapidly overexpressed in the first stages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a950428965d8f9fcb44cc630ff54d

Adolescent administration of Δ

Autor: Miguel, Garzón, Gang, Wang, June, Chan, Faye, Bourie, Ken, Mackie, Virginia M, Pickel

Publikováno v: IBRO Neuroscience Reports

Long-term cannabis use during adolescence has deleterious effects in brain that are largely ascribed to the activation of cannabinoid-1 receptors (CB1Rs) by delta-9-tetrahydrocannabinol (∆9-THC), the primary psychoactive compound in marijuana. Syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b03004304b8098b3141dcd72323ca6f0
https://pubmed.ncbi.nlm.nih.gov/34667972

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

Autor: Edmond Fleischer, Vincent Kam Wai Wong, Thorsten Berg, Sara Abdelfatah, Thomas Efferth, Anette Klinger, Li Jun Yang, Qi Huang, Sami Hamdoun, Henry Johannes Greten, Angela Berg

Publikováno v: Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Acta Pharmaceutica Sinica. B

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ace647c8e4c5307f8c6cf16d50546d6
http://www.sciencedirect.com/science/article/pii/S221138351830827X