Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Avery Sader"'
Autor:
Guanghu Tong, Samantha Griffin, Avery Sader, Anna B. Crowell, Ken Beavers, Jerry Watson, Zachary Buchan, Shuming Chen, Ryan A. Shenvi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Minor changes to complex structures can exert major influences on synthesis strategy and functional properties. Here we explore two parallel series of picrotoxinin (PXN, 1) analogs and identify leads with selectivity between mammalian and in
Externí odkaz:
https://doaj.org/article/6e591d0e58514b70af6f7d48884af0c8
Autor:
Yannick Djoumbou-Feunang, Jeremy Wilmot, John Kinney, Pritam Chanda, Pulan Yu, Avery Sader, Max Sharifi, Scott Smith, Junjun Ou, Jie Hu, Elizabeth Shipp, Dirk Tomandl, Siva P. Kumpatla
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
The global cost-benefit analysis of pesticide use during the last 30 years has been characterized by a significant increase during the period from 1990 to 2007 followed by a decline. This observation can be attributed to several factors including, bu
Externí odkaz:
https://doaj.org/article/33532c831ec64697b2df997d64040383
Autor:
Alejandra Young, Uma Dandekar, Calvin Pan, Avery Sader, Jie J Zheng, Richard A Lewis, Debora B Farber
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162273 (2016)
Ocular albinism type 1 (OA), caused by mutations in the OA1 gene, encodes a G-protein coupled receptor, OA1, localized in melanosomal membranes of the retinal pigment epithelium (RPE). This disorder is characterized by both RPE macro-melanosomes and
Externí odkaz:
https://doaj.org/article/6467a785dc48450a8ddbece4c801fcbf
Autor:
Guanghu Tong, Samantha Griffin, Avery Sader, Anna Crowell, Ken Beavers, Jerry Watson, Zachary Buchan, Shuming Chen, Ryan Shenvi
Natural product total synthesis enables gain of function through deep-seated modification of structure. Synthetic difficulty can, however, obstruct meaningful optimization campaigns. To simplify access, the complexity of the target (TGT) can be lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f6c04850d60085ab6bcfc881a826074
https://doi.org/10.26434/chemrxiv-2022-0l4nt
https://doi.org/10.26434/chemrxiv-2022-0l4nt
Autor:
C. Avery Sader, K. N. Houk
Publikováno v:
ARKIVOC, Vol 2014, Iss 3, Pp 170-183 (2014)
Externí odkaz:
https://doaj.org/article/233e4b43832c4f069e79a6ffca80fe94
Autor:
Nitinchandra D. Patel, Marisa C. Kozlowski, Osvaldo Gutierrez, Chris H. Senanayake, Carl A. Busacca, Keith R. Fandrick, C. Avery Sader, Daniel R. Fandrick, Yike Zou
Publikováno v:
Organic Letters
A copper-catalyzed site-selective propargylation/allenylation reaction toward carbonyl compounds has been mechanistically investigated using a computational approach. Different reaction pathways and catalytic cycles were investigated. Control of the
Autor:
Klaus Wagner, Reginaldo A. Saraceno, Dongyue Xin, Christofer S. Tautermann, Keith Horspool, Zheng Yang, Om Chaudhary, Nina C. Gonnella, Keith R. Fandrick, C. Avery Sader, Paul-James Jones, Gordon Hansen, Chris H. Senanayake, Carl A. Busacca
Publikováno v:
The Journal of Organic Chemistry. 82:5135-5145
An accurate and efficient procedure was developed for performing 13C NMR chemical shift calculations employing density functional theory with the gauge invariant atomic orbitals (DFT-GIAO). Benchmarking analysis was carried out, incorporating several
Autor:
Charles Avery Sader, Nina C. Gonnella, Klaus Wagner, Minli Xing, Udo Fischer, Keith R. Fandrick, Paul-James Jones, Dongyue Xin
Publikováno v:
Organic & Biomolecular Chemistry. 15:928-936
The calculation of 15N NMR chemical shifts has been systematically investigated using density functional theory-gauge including/invariant atomic orbitals (DFT-GIAO) approximation at the B3LYP/cc-pVDZ level of theory. General linear regression terms f
Autor:
C. Avery Sader, Christian A. Malapit, Maurice A. Marsini, Frederic G. Buono, Kanwar Sidhu, Keith R. Fandrick, Chris H. Senanayake, Jonathan T. Reeves, Carl A. Busacca
Publikováno v:
Journal of the American Chemical Society. 137:9481-9488
An electrophilic cyanation of aryl Grignard or lithium reagents, generated in situ from the corresponding aryl bromides or iodides, by a transnitrilation with dimethylmalononitrile (DMMN) was developed. DMMN is a commercially available, bench-stable