Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.

Autor: Jamie J Arnold, Suresh D Sharma, Joy Y Feng, Adrian S Ray, Eric D Smidansky, Maria L Kireeva, Aesop Cho, Jason Perry, Jennifer E Vela, Yeojin Park, Yili Xu, Yang Tian, Darius Babusis, Ona Barauskus, Blake R Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E Cameron

Publikováno v: PLoS Pathogens, Vol 8, Iss 11, p e1003030 (2012)

Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects. Development of antiviral ribonucleosides for treatment of hepatiti

Externí odkaz: https://doaj.org/article/b319ca8392e34c9a89590b29d3f91226

Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM

Autor: Yen-Chen Lin, Yi-Min Wu, Averell Gnatt, Chun-Hsiung Wang, Chia-Chi Chang, Jen-wei Chang, Wei-Hau Chang, Shih-Hsin Huang, Pei-lun Wu, Xiaopeng Hu

Publikováno v: The EMBO Journal. 31:3575-3587

In mammals, a distinct RNA polymerase II form, RNAPII(G) contains a novel subunit Gdown1 (encoded by POLR2M), which represses gene activation, only to be reversed by the multisubunit Mediator co-activator. Here, we employed single-particle cryo-elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69972c6660bdf61cb4cd2cba42386f9d
https://doi.org/10.1038/emboj.2012.205

Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes

Autor: Todd E. Adamson, Tiandao Li, Richard A. Young, Nicholas B. Loudas, Peter B. Rahl, Averell Gnatt, Jiannan Guo, Jeffrey J. Cooper, David H. Price, Katayoun Varzavand, Bo Cheng, Xiaopeng Hu

Publikováno v: PMC

Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by P-TEFb. We present evidence that Gdown1, the product of the POLR2M gene that renders Pol II res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85e092afddd7437b3530ad47d048799
https://doi.org/10.1016/j.molcel.2011.10.022

Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

Autor: Lucyna Lubkowska, Averell Gnatt, Dong Wang, Philip J. Brooks, Celine Walmacq, Kathleen Scibelli, Lanfeng Wang, Jenny Chong, Mikhail Kashlev

Publikováno v: Walmacq, Celine; Wang, Lanfeng; Chong, Jenny; Scibelli, Kathleen; Lubkowska, Lucyna; Gnatt, Averell; et al.(2015). Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. Proceedings of the National Academy of Sciences of the United States of America, 112(5), E410-E419. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/5fw5b336

SignificanceCyclopurines are bulky oxidative DNA lesions that strongly block RNA polymerase II (Pol II) to interfere with gene transcription and replication in mammalian cells. Cells developed a mechanism enabling slow transcriptional bypass of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8b7e46b3b033698b58f27b8cc7560b
https://pubmed.ncbi.nlm.nih.gov/25605892

Retraction: Oncogene PKCε controls INrf2–Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2

Autor: Anil K. Jaiswal, Suryakant K. Niture, Averell Gnatt

Publikováno v: Journal of Cell Science. 130:815-815

The INrf2 (Keap1)–Nrf2 cell sensor complex has a crucial role in protection against chemical- and radiation-induced oxidative stress and cellular transformation. INrf2, in association with Cul3–Rbx1, ubiquitylates and degrades Nrf2. Exposure to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab909306aa18c8e63de32097d7b6b327
https://doi.org/10.1242/jcs.201954