Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Avantika S. Chitre"'
Autor:
Avantika S. Chitre, Ping Wu, Benjamin T. Walters, Xiangdan Wang, Alexandre Bouyssou, Xiangnan Du, Isabelle Lehoux, Rina Fong, Alisa Arata, Joyce Chan, Die Wang, Yvonne Franke, Jane L. Grogan, Ira Mellman, Laetitia Comps-Agrar, Weiru Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell receptor signaling and as such is an attractive target for cancer immunotherapy. Although the role of the HPK1 kinase domain (KD) has been extensively characterized,
Externí odkaz:
https://doaj.org/article/606ad94308a5488bb57edc5d41149491
Autor:
Marcin Kowanetz, Thomas Powles, Hartmut Koeppen, Jane Grogan, Patrick Caplazi, Ira Mellman, Wei Zou, Sanjeev Mariathasan, Priti S. Hegde, Mark McCleland, Jacqueline McBride, Zora Modrusan, Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, III, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Shadi Toghi Eshgi, W. Rodney Mathews, William E O'Gorman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.Methods Here,
Externí odkaz:
https://doaj.org/article/ccc1e210948b41af9f921790f0cfde0d
Autor:
Youngsu Kwon, Avantika S. Chitre, Denise E. de Almeida Nagata, Karl L. Banta, Stephanie Mittman, Keith R. Anderson, Rafael Cubas, Kristin Harden Bowles, Patrícia de Almeida, Eugene Y. Chiang, Xiangnan Du, Søren Warming, Jane L. Grogan, Brent S. McKenzie
Publikováno v:
European Journal of Immunology. 50:891-902
CD96 is a member of the poliovirus receptor (PVR, CD155)-nectin family that includes T cell Ig and ITIM domain (TIGIT) and CD226. While CD96, TIGIT, and CD226 have important roles in regulating NK cell activity, and TIGIT and CD226 have also been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ca155c5655ee151dba33f44f53989f
https://doi.org/10.1002/eji.201948405
https://doi.org/10.1002/eji.201948405
Autor:
Karl L, Banta, Xiaozheng, Xu, Avantika S, Chitre, Amelia, Au-Yeung, Chikara, Takahashi, William E, O'Gorman, Thomas D, Wu, Stephanie, Mittman, Rafael, Cubas, Laetitia, Comps-Agrar, Amit, Fulzele, Eric J, Bennett, Jane L, Grogan, Enfu, Hui, Eugene Y, Chiang, Ira, Mellman
Publikováno v:
Immunity. 55(3)
Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT blockade modulate anti-tumor CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d237098913f41245956df8c61565e97
https://pubmed.ncbi.nlm.nih.gov/35263569
https://pubmed.ncbi.nlm.nih.gov/35263569
Autor:
W. Rodney Mathews, Ying-Jiun Chen, Marcin Kowanetz, Jane L. Grogan, Chikara Takahashi, Mark McCleland, Ira Mellman, Thomas Powles, Jacqueline McBride, Mark D. Robida, Avantika S. Chitre, William E. O'Gorman, Shravan Madireddi, Hartmut Koeppen, Edward E. Kadel, Zora Modrusan, Patrick Caplazi, Thomas D. Wu, Shadi Toghi Eshgi, Alexis Scherl, Rhea Nersesian, Ehab Elgabry, Amelia Au-Yeung, Jeffrey Hung, Namrata Patil, Wei Zou, Priti Hegde, Patrícia de Almeida, Sanjeev Mariathasan, Romain Banchereau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundCD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.MethodsHere, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973117f29bc29683e2495f0620864a71
https://jitc.bmj.com/content/9/4/e002231.full
https://jitc.bmj.com/content/9/4/e002231.full
Autor:
Namrata S. Patil, Barzin Y. Nabet, Sören Müller, Hartmut Koeppen, Wei Zou, Jennifer Giltnane, Amelia Au-Yeung, Shyam Srivats, Jason H. Cheng, Chikara Takahashi, Patricia E. de Almeida, Avantika S. Chitre, Jane L. Grogan, Linda Rangell, Sangeeta Jayakar, Maureen Peterson, Allison W. Hsia, William E. O’Gorman, Marcus Ballinger, Romain Banchereau, David S. Shames
Publikováno v:
Cancer Cell. 40:289-300.e4
Inhibitors of the programmed cell death-1 (PD-1/PD-L1) signaling axis are approved to treat non-small cell lung cancer (NSCLC) patients, based on their significant overall survival (OS) benefit. Using transcriptomic analysis of 891 NSCLC tumors from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1819ce15d429daff54cb2e2e0cccbb6e
https://doi.org/10.1016/j.ccell.2022.02.002
https://doi.org/10.1016/j.ccell.2022.02.002
Autor:
Karl L. Banta, Xiaozheng Xu, Avantika S. Chitre, Amelia Au-Yeung, Chikara Takahashi, William E. O’Gorman, Thomas D. Wu, Stephanie Mittman, Rafael Cubas, Laetitia Comps-Agrar, Amit Fulzele, Eric J. Bennett, Jane L. Grogan, Enfu Hui, Eugene Y. Chiang, Ira Mellman
Publikováno v:
Immunity. 55:512-526.e9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3942a7e957a961c22110f86bd394d059
https://doi.org/10.1016/j.immuni.2022.02.005
https://doi.org/10.1016/j.immuni.2022.02.005
Autor:
Eugene Y, Chiang, Patricia E, de Almeida, Denise E, de Almeida Nagata, Kristin Harden, Bowles, Xiangnan, Du, Avantika S, Chitre, Karl L, Banta, Youngsu, Kwon, Brent, McKenzie, Stephanie, Mittman, Rafael, Cubas, Keith R, Anderson, Søren, Warming, Jane L, Grogan
Publikováno v:
European journal of immunologyReferences. 50(6)
CD96 is a member of the poliovirus receptor (PVR, CD155)-nectin family that includes T cell Ig and ITIM domain (TIGIT) and CD226. While CD96, TIGIT, and CD226 have important roles in regulating NK cell activity, and TIGIT and CD226 have also been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::689896c616bf8c5edd047ab9153ab68a
https://pubmed.ncbi.nlm.nih.gov/32043568
https://pubmed.ncbi.nlm.nih.gov/32043568
Autor:
Leonard D. Goldstein, Ira Mellman, Mahrukh Huseni, Avantika S. Chitre, Sanjeev Mariathasan, Thomas D. Wu, Ying-Jiun J. Chen, Zora Modrusan, Patrick Caplazi, William E. O'Gorman, Jane L. Grogan, Chikara Takahashi, Ivette Estay, Shilpa Keerthivasan, Lélia Delamarre, Hyang Mi Lee, Romain Banchereau, Denise E. de Almeida Nagata, Xiangnan Du, Marcus Ballinger, Richard Bourgon, Chungkee Poon, Patrícia de Almeida, Karl L. Banta, Hina Iftikhar, Meghna Das Thakur, Eugene Y. Chiang, Shravan Madireddi, Amelia Au-Yeung
Publikováno v:
Nature. 579(7798)
Despite the resounding clinical success in cancer treatment of antibodies that block the interaction of PD1 with its ligand PDL11, the mechanisms involved remain unknown. A major limitation to understanding the origin and fate of T cells in tumour im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e07850f9875d46b5ddeb4bdc5d3ce60
https://pubmed.ncbi.nlm.nih.gov/32103181
https://pubmed.ncbi.nlm.nih.gov/32103181
Autor:
Montha Pao, Averil Ma, Luis J. Montaner, Mohamed Abdel-Mohsen, Steven G. Deeks, Yenny Y. Rosli, Joseph M. McCune, Michael G. Kattah, Monika Deswal, Charles C. Kim, Ma Somsouk, Peter W. Hunt, Avantika S. Chitre
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 3, p e1006806 (2018)
PLoS pathogens, vol 14, iss 3
PLoS Pathogens, Vol 14, Iss 3, p e1006806 (2018)
PLoS pathogens, vol 14, iss 3
Untreated Human Immunodeficiency Virus (HIV) infection is characterized by intestinal epithelial barrier dysfunction and chronic inflammation, related features that are attenuated to variable degrees by suppressive antiretroviral therapy (ART). Speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd13aac81a015af5c4ac981a3ea5d9f
http://europepmc.org/articles/PMC5854440
http://europepmc.org/articles/PMC5854440