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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Autor:
Sungki Hong, Mallory A Freeberg, Ting Han, Avani Kamath, Yao Yao, Tomoko Fukuda, Tsukasa Suzuki, John K Kim, Ken Inoki
Publikováno v:
eLife, Vol 6 (2017)
The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1 to regulate the translation of 5’TOP mRNAs such as those encoding ribosome proteins (RP). However, the roles of LARP1 in the translation of 5’TOP mRNAs are controv
Externí odkaz:
https://doaj.org/article/1be33cf3c8b74fcaae03444cd7d5f0d1
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Autor:
John Kim, Tsukasa Suzuki, Sungki Hong, Mallory A. Freeberg, Avani Kamath, Ken Inoki, Yao Yao, Tomoko Fukuda, Ting Han
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1 to regulate the translation of 5’TOP mRNAs such as those encoding ribosome proteins (RP). However, the roles of LARP1 in the translation of 5’TOP mRNAs are controv
Autor:
Blake Arthurs, Liangyou Rui, Deqiang Zhang, Lei Yin, Avani Kamath, Xin Tong, Ken Inoki, Anirvan Guha
Publikováno v:
The Journal of biological chemistry. 289(37)
The clock protein BMAL1 (brain and muscle Arnt-like protein 1) participates in circadian regulation of lipid metabolism, but its contribution to insulin AKT-regulated hepatic lipid synthesis is unclear. Here we used both Bmal1(-/-) and acute liver-sp