MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of-concept trial

Autor: Katherine J Rennie, Miles Witham, Penny Bradley, Andrew Clegg, Stephen Connolly, Helen C Hancock, Shaun Hiu, Leanne Marsay, Claire McDonald, Laura Robertson, Laura Simms, Alison J Steel, Claire J Steves, Bryony Storey, James Wason, Nina Wilson, Thomas von Zglinicki, Avan A P Sayer

Publikováno v: Rennie, K J, Witham, M, Bradley, P, Clegg, A, Connolly, S, Hancock, H C, Hiu, S, Marsay, L, McDonald, C, Robertson, L, Simms, L, Steel, A J, Steves, C J, Storey, B, Wason, J, Wilson, N, Von Zglinicki, T & Sayer, A A P 2022, ' MET-PREVENT : metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty-protocol for a double-blind, randomised controlled proof-of-concept trial ', BMJ Open, vol. 12, no. 7, e061823 . https://doi.org/10.1136/bmjopen-2022-061823

Introduction Skeletal muscle dysfunction is central to both sarcopenia and physical frailty, which are associated with a wide range of adverse outcomes including falls and fractures, longer hospital stays, dependency and the need for care. Resistance

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https://doi.org/10.1136/bmjopen-2022-061823