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A neutralizing antibody prevents postfusion transition of measles virus fusion protein.

Autor: Zyla, Dawid S., Marca, Roberta Della, Niemeyer, Gele, Zipursky, Gillian, Stearns, Kyle, Leedale, Cameron, Sobolik, Elizabeth B., Callaway, Heather M., Hariharan, Chitra, Peng, Weiwei, Parekh, Diptiben, Marcink, Tara C., Avalos, Ruben Diaz, Horvat, Branka, Mathieu, Cyrille, Snijder, Joost, Greninger, Alexander L., Hastie, Kathryn M., Niewiesk, Stefan, Moscona, Anne

Publikováno v: Science; 6/28/2024, Vol. 384 Issue 6703, p1423-1423, 1p, 1 Diagram

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies.

Autor: Donnellan FR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, OX1 3QU, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK., Rayaprolu V; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Current affiliation: Pacific Northwest Cryo-EM Center, Oregon Health and Sciences University, Portland, OR 97201, USA., Rijal P; Center for Translational Immunology, Chinese Academy of Medical Science Oxford Institute, Nuffield Department of Medicine, University of Oxford, OX3 7BN, UK.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK., O'Dowd V; UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK., Parvate A; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Current affiliation: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Callaway H; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Current affiliation: Chemistry & Biochemistry Building, Montana State University, Bozeman, MT 59717, USA., Hariharan C; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Parekh D; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Hui S; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Current Affiliation: Department of Pathology & Immunology, Washington University School of Medicine. St. Louis MO 63110, USA., Shaffer K; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine. University of California San Diego. La Jolla, CA 92037, USA., Avalos RD; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Hastie K; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Schimanski L; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK., Müller-Kräuter H; Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany., Strecker T; Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany., Balaram A; Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin, Madison, WI, 53713, USA., Halfmann P; Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin, Madison, WI, 53713, USA., Saphire EO; Center for Vaccine Innovation, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine. University of California San Diego. La Jolla, CA 92037, USA., Lightwood DJ; UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK., Townsend AR; Center for Translational Immunology, Chinese Academy of Medical Science Oxford Institute, Nuffield Department of Medicine, University of Oxford, OX3 7BN, UK.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK., Draper SJ; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, OX1 3QU, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.