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Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract The spike protein (S) of SARS-CoV-2 induces neutralizing antibodies and is the key component of current COVID-19 vaccines. The most efficacious COVID-19 vaccines are genetically-encoded spikes with a double proline substitution in the hinge

Externí odkaz: https://doaj.org/article/2c5d3e1e3a7e47e1962a95fc294bb57c

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Corneal Breakthrough Haze After Photorefractive Keratectomy With Mitomycin C: Incidence and Risk Factors

Autor: Igor Kaiserman, Naʼava Sadi, Michael Mimouni, Gur Munzer, Tzahi Sela, Shmuel Levartovsky

Publikováno v: Cornea. 36:961-966

PURPOSE To identify preoperative and intraoperative factors affecting breakthrough corneal haze incidence after photorefractive keratectomy (PRK) with mitomycin C (MMC). METHODS In this retrospective study of PRK performed at the Care Vision Refracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53077c26c62ad878645526892e2b6796
https://doi.org/10.1097/ico.0000000000001231

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Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy

Autor: Christophe Blanchetot, Michael A. Saunders, Paolo Michieli, Virginia Morello, Valérie Hanssens, Mohamed El Khattabi, Anna Hultberg, Marie Godar, Cristina Basilico, Hans de Haard, Natalie De Jonge, Ava Sadi, Bart N. Lambrecht

Publikováno v: Scientific Reports
Scientific Reports, 6:31621. Nature Publishing Group
SCIENTIFIC REPORTS

Bispecific antibodies are of great interest due to their ability to simultaneously bind and engage different antigens or epitopes. Nevertheless, it remains a challenge to assemble, produce and/or purify them. Here we present an innovative dual anti-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4fa6d3bcddbf719b096dc5d6f65066
http://europepmc.org/articles/PMC4992859

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Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies

Autor: Christian Cambillau, Alex Klarenbeek, Nico Ongenae, Anke Kretz-Rommel, Ava Sadi, Remy Loris, Hans de Haard, Natalie De Jonge, Silvia Spinelli, Anna Hultberg, Erik G. Hofman, Christophe Blanchetot, Aline Desmyter

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (26), pp.13846-13854. ⟨10.1074/jbc.M115.695528⟩
'Journal of Biological Chemistry ', vol: 291, pages: 13846-13854 (2016)
Journal of Biological Chemistry, 2016, 291 (26), pp.13846-13854. ⟨10.1074/jbc.M115.695528⟩
The Journal of Biological Chemistry

Interleukin 6 plays a key role in mediating inflammatory reactions in autoimmune diseases and cancer, where it is also involved in metastasis and tissue invasion. Neutralizing antibodies against IL-6 and its receptor have been approved for therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10344b4a46e0360f825d380c857a93b
https://hal.archives-ouvertes.fr/hal-01439109

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Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics

Autor: Nico Ongenae, Anna Hultberg, Christian Cambillau, Christophe Blanchetot, Torsten Dreier, Silvia Spinelli, Wieger Hemrika, John Wijdenes, Ava Sadi, Rob C. Roovers, Alex Klarenbeek, Anke Kretz-Rommel, Hans de Haard, Georg Schragel, Aline Desmyter

Publikováno v: Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2016, 29 (4), pp.123-133. ⟨10.1093/protein/gzw003⟩
Protein Engineering, Design and Selection, 2016, 29 (4), pp.123-133. ⟨10.1093/protein/gzw003⟩

Highly potent human antibodies are required to therapeutically neutralize cytokines such as interleukin-6 (IL-6) that is involved in many inflammatory diseases and malignancies. Although a number of mutagenesis approaches exist to perform antibody af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49a6a706c7c5b3a85e8c888687bc7cd
https://hal.archives-ouvertes.fr/hal-01439062

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