Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ava Faridi"'
Autor:
Ibrahim Javed, Guotao Peng, Yanting Xing, Tianyu Yu, Mei Zhao, Aleksandr Kakinen, Ava Faridi, Clare L. Parish, Feng Ding, Thomas P. Davis, Pu Chun Ke, Sijie Lin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Treating Alzheimer’s disease, one of the most common neurodegenerative diseases, is of wide interest. Here, the authors report on the development of casein coated gold nanoparticles which were able to cross the blood brain barrier and protect again
Externí odkaz:
https://doaj.org/article/e0577051f8ce4da6ad905f6a508a48cf
Autor:
Pouya Faridi, Thomas P. Davis, Yanting Xing, Ava Faridi, Feng Ding, Anthony W. Purcell, Emily H. Pilkington, Ibrahim Javed, Aleksandr Kakinen, Aparna Nandakumar, Pu Chun Ke, Kairi Koppel, Ritchlynn Aranha
Publikováno v:
Biomacromolecules
Alzheimer’s disease (AD) is the most severe form of neurological disorder, characterized by the presence of extracellular amyloid-β (Aβ) plaques and intracellular tau tangles. For decades, therapeutic strategies against the pathological symptoms
Autor:
Thomas P. Davis, Ava Faridi, Pu Chun Ke, Stephen J. Kent, Hannah G. Kelly, Wen Yang, Pengyu Chen, Anthony W. Purcell, Pouya Faridi, Chuanyu Wang
Publikováno v:
Biomacromolecules
Alzheimer’s disease (AD) is a primary neurological disease with no effective cure. A hallmark of AD is the presence of intracellular tangles and extracellular plaques derived from the aberrant aggregation of tau- and beta-amyloid (Aβ). Aβ present
Autor:
Emily H. Pilkington, Thomas P. Davis, Pouya Faridi, Sijie Lin, Ruhong Zhou, Anthony W. Purcell, Yunxiang Sun, Pu Chun Ke, Aleksandr Kakinen, Ibrahim Javed, Ava Faridi, Feng Ding
Publikováno v:
Science Bulletin. 64:26-35
Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence sug
Autor:
Chi Zhang, Thomas P. Davis, Ava Faridi, Ye Yang, Feng Ding, Yunxiang Sun, Pu Chun Ke, Weiguo Cao, Aleksandr Kakinen
Publikováno v:
Nanoscale
Featuring small sizes, caged structures, low cytotoxicity and the capability to cross biological barriers, fullerene hydroxy derivatives named fullerenols have been explored as nanomedicinal candidates for amyloid inhibition. Understanding the surfac
Autor:
Emily H. Pilkington, Ava Faridi, Thomas P. Davis, Aleksandr Kakinen, Ove J. R. Gustafsson, Ibrahim Javed, Pu Chun Ke, Miaoyi Wang
Publikováno v:
Journal of materials chemistry. B. 6(38)
The protein corona is a concept central to a range of disciplines exploiting the bio–nano interface. As the literature continues to expand in this field, it is essential to condense and contextualize the in vitro and in vivo proteome databases accu
Autor:
AVA FARIDI
Proteins and peptides can aggregate and misfold into long twisted fibrils called amyloids. This phenomenon leads to toxicity and cell degeneration and contributes to a range of human diseases, including type 2 diabetes, Alzheimer’s and Parkinson’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31037657e318ce9577f1fa42c2350afd
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:1803-1809
Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of human diseases. The amyloid aggregation of human islet amyloid polypeptide (IAPP) and alpha synuclein (αS), specifically, is a hallmark of type 2 diabetes (T2D) an
Autor:
Antoni Sánchez-Ferrer, Mei Zhao, Thomas P. Davis, Tianyu Yu, Ava Faridi, Pu Chun Ke, Aleksandr Kakinen, Sijie Lin, Guotao Peng, Raffaele Mezzenga, Ibrahim Javed
Publikováno v:
Nano Letters. 18:5797-5804
Amyloid diseases are global epidemics with no cure available. Herein, we report a first demonstration of in vivo mitigation of amyloidogenesis using biomimetic nanotechnology. Specifically, the amyloid fragments (ba) of β-lactoglobulin, a whey prote
Autor:
Paul Wilson, Ava Faridi, Thomas P. Davis, Cleidi Zampronio, Pu Chun Ke, Juan Ramon Hernandez-Fernaud, Yanting Xing, Ove J. R. Gustafsson, Aleksandr Kakinen, Feng Ding, Emily H. Pilkington
Publikováno v:
ACS Nano. 12:6066-6078
Amyloids may be regarded as native nanomaterials that form in the presence of complex protein mixtures. By drawing an analogy with the physicochemical properties of nanoparticles in biological fluids, we hypothesized that amyloids should form a prote