Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ava, Keyvani Chahi"'
Publikováno v:
HemaSphere, Vol 8, Iss 8, Pp n/a-n/a (2024)
Abstract Strict control over hematopoietic stem cell decision making is essential for healthy life‐long blood production and underpins the origins of hematopoietic diseases. Acute myeloid leukemia (AML) in particular is a devastating hematopoietic
Externí odkaz:
https://doaj.org/article/bf6d0938780a4c0ab6b271858aea0e8d
Sex Differences in Glomerular Protein Expression and Effects of Soy-Based Diet on Podocyte Signaling
Autor:
Afreeda Mahesaniya, Casey R. Williamson, Ava Keyvani Chahi, Claire E. Martin, Alexander E. Mitro, Peihua Lu, Laura A. New, Katrina L. Watson, Roger A. Moorehead, Nina Jones
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 9 (2022)
Background: Kidney disease is a major public health issue arising from loss of glomerular podocyte function, and there are considerable sex differences in its prognosis. Evidence suggests a renoprotective effect of estrogen and soy diet-derived phyto
Externí odkaz:
https://doaj.org/article/342064edf3344362bea5086c11991eb8
Autor:
Ana Vujovic, Laura de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian A. Yee, Sampath K. Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
Publikováno v:
Blood Cancer Discovery. 4:180-207
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d13c8425215d000309cd12391bf1f8
https://doi.org/10.1158/2643-3230.bcd-22-0086
https://doi.org/10.1158/2643-3230.bcd-22-0086
Autor:
Muluken S. Belew, Sonam Bhatia, Ava Keyvani Chahi, Stefan Rentas, Jonathan S. Draper, Kristin J. Hope
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1384-1397 (2018)
Summary: MSI2, which is expressed predominantly in hematopoietic stem and progenitor cells (HSPCs), enforces HSPC expansion when overexpressed and is upregulated in myeloid leukemias, indicating its regulated transcription is critical to balanced sel
Externí odkaz:
https://doaj.org/article/696a4f9d5be34658b2a9828b04d556c1
Autor:
Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Veronique Voisin, Gabriela Krivdova, Eric Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope
Publikováno v:
Blood. 140:992-1008
Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136c7c0a928ffbfa41375aa2c6c2a365
https://doi.org/10.1182/blood.2021014698
https://doi.org/10.1182/blood.2021014698
Autor:
Claire E. Martin, Noah J. Phippen, Ava Keyvani Chahi, Manali Tilak, Sara L. Banerjee, Peihua Lu, Laura A. New, Casey R. Williamson, Mathew J. Platt, Jeremy A. Simpson, Mira Krendel, Nicolas Bisson, Anne-Claude Gingras, Nina Jones
Publikováno v:
Journal of the American Society of Nephrology. 33:1546-1567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2316411dd8535b9902c84cf4cbe57a84
https://doi.org/10.1681/asn.2021101343
https://doi.org/10.1681/asn.2021101343
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Table S5 shows the log2 fold change of differentially expressed transcripts from the ELAVL1 knockout RN2c RNA-sequencing data set.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238801bda66a9156f6af773fa36da1b5
https://doi.org/10.1158/2643-3230.22725570
https://doi.org/10.1158/2643-3230.22725570
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Supplemental Figure S4 shows the validation of ELAVL1 knockdown by western blot and effects of ELAVL1 loss on human primary AML cells in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cb536bc316f972180d6869ba2df29c
https://doi.org/10.1158/2643-3230.22725594
https://doi.org/10.1158/2643-3230.22725594
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c408b73a88713bd19863989035bb281
https://doi.org/10.1158/2643-3230.c.6572000
https://doi.org/10.1158/2643-3230.c.6572000
Autor:
Ana Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
SUMMARYAcute myeloid leukemia (AML) progression and relapse is fueled by self-renewing leukemic stem cells (LSCs) whose molecular determinants have been difficult to discern from normal hematopoietic stem cells (HSCs) or to uncover in screening appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::661491ba6391e52016995ed0d18dbb29
https://doi.org/10.1101/2022.06.11.494613
https://doi.org/10.1101/2022.06.11.494613