Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

Autor: Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach

Publikováno v: PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)

α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in

Externí odkaz: https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b

Leveraging blood-based transcriptomics to detect acute cellular rejection in lung transplant

Autor: Auyon J. Ghosh, MD, MPH, Matthew Moll, MD, MPH, Shikshya Shrestha, PhD, Sergio Poli, MD, Stephen J. Glatt, PhD, Hilary J. Goldberg, MD, Andrew M. Courtwright, MD, Souheil Y. El-Chemaly, MD

Publikováno v: JHLT Open, Vol 4, Iss , Pp 100081- (2024)

Acute cellular rejection (ACR) is one of the main risk factors for chronic allograft dysfunction, the primary contributor to poor long-term survival in lung transplant recipients. We sought to develop a blood-based transcriptomic risk score (TRS) to

Externí odkaz: https://doaj.org/article/bb29725f0f1b4a8fae559b9f86c175c5

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study

Autor: Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan, Craig P. Hersh, the COPDGene Investigators

Publikováno v: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-9 (2020)

Abstract Background Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D

Externí odkaz: https://doaj.org/article/aa4abaa66f2c4839ad162342221a690e

Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies

Autor: Matthew Moll, Sharon M. Lutz, Auyon J. Ghosh, Phuwanat Sakornsakolpat, Craig P. Hersh, Terri H. Beaty, Frank Dudbridge, Martin D. Tobin, Murray A. Mittleman, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho

Publikováno v: BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)

Introduction Family history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (Polygenic Risk Score, PRS). Whether the PRS and family history provide compleme

Externí odkaz: https://doaj.org/article/97ef5f120575410ba14b9fa725e334df

Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease

Autor: Matthew Moll, Adel Boueiz, Auyon J. Ghosh, Aabida Saferali, Sool Lee, Zhonghui Xu, Jeong H. Yun, Brian D. Hobbs, Craig P. Hersh, Don D. Sin, Ruth Tal-Singer, Edwin K. Silverman, Michael H. Cho, Peter J. Castaldi, James D. Crapo, Barry J. Make, Elizabeth A. Regan, Terri Beaty, Ferdouse Begum, Michael Cho, Dawn L. DeMeo, Adel R. Boueiz, Marilyn G. Foreman, Eitan Halper-Stromberg, Lystra P. Hayden, Jacqueline Hetmanski, John E. Hokanson, Nan Laird, Christoph Lange, Sharon M. Lutz, Merry-Lynn McDonald, Margaret M. Parker, Dmitry Prokopenko, Dandi Qiao, Phuwanat Sakornsakolpat, Emily S. Wan, Juan Pablo Centeno, Jean-Paul Charbonnier, Harvey O. Coxson, Craig J. Galban, MeiLan K. Han, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, Pietro Nardelli, John D. Newell, Aleena Notary, Andrea Oh, James C. Ross, Raul San Jose Estepar, Joyce Schroeder, Jered Sieren, Berend C. Stoel, Juerg Tschirren, Edwin Van Beek, Bram van Ginneken, Eva van Rikxoort, Gonzalo Vegas Sanchez-Ferrero, Lucas Veitel, George R. Washko, Carla G. Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Katherine Pratte, Matt Strand, Gregory Kinney, Kendra A. Young, Surya P. Bhatt, Jessica Bon, Alejandro A. Diaz, Susan Murray, Xavier Soler, Russell P. Bowler, Katerina Kechris, Farnoush Banaei-Kashani

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 205:161-170

Rationale: The ability of peripheral blood biomarkers to assess COPD risk and progression is unknown. Genetics and gene expression may capture important aspects of COPD-related biology that predict...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97e212e59738bc6a7d7afd610ced65f5
https://doi.org/10.1164/rccm.202107-1584oc