Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Auyon J Ghosh"'
Autor:
Matthew Moll, Julian Hecker, John Platig, Jingzhou Zhang, Auyon J. Ghosh, Katherine A. Pratte, Rui-Sheng Wang, Davin Hill, Iain R. Konigsberg, Joe W. Chiles, III, Craig P. Hersh, Peter J. Castaldi, Kimberly Glass, Jennifer G. Dy, Don D. Sin, Ruth Tal-Singer, Majd Mouded, Stephen I. Rennard, Gary P. Anderson, Gregory L. Kinney, Russell P. Bowler, Jeffrey L. Curtis, Merry-Lynn McDonald, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105429- (2024)
Summary: Background: Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to define high-risk COPD subtypes using genetics (polygenic risk score
Externí odkaz:
https://doaj.org/article/a0549eb45ebc4c8e9d1d5f0c4da19d8b
Autor:
Auyon J. Ghosh, MD, MPH, Matthew Moll, MD, MPH, Shikshya Shrestha, PhD, Sergio Poli, MD, Stephen J. Glatt, PhD, Hilary J. Goldberg, MD, Andrew M. Courtwright, MD, Souheil Y. El-Chemaly, MD
Publikováno v:
JHLT Open, Vol 4, Iss , Pp 100081- (2024)
Acute cellular rejection (ACR) is one of the main risk factors for chronic allograft dysfunction, the primary contributor to poor long-term survival in lung transplant recipients. We sought to develop a blood-based transcriptomic risk score (TRS) to
Externí odkaz:
https://doaj.org/article/bb29725f0f1b4a8fae559b9f86c175c5
Autor:
Matthew Moll, Brian D. Hobbs, Aravind Menon, Auyon J. Ghosh, Rachel K. Putman, Takuya Hino, Akinori Hata, Edwin K. Silverman, John Quackenbush, Peter J. Castaldi, Craig P. Hersh, Michael J. McGeachie, Don D. Sin, Ruth Tal-Singer, Mizuki Nishino, Hiroto Hatabu, Gary M. Hunninghake, Michael H. Cho
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Interstitial lung abnormalities (ILA) are radiologic findings that may progress to idiopathic pulmonary fibrosis (IPF). Blood gene expression profiles can predict IPF mortality, but whether these same genes associate with ILA and
Externí odkaz:
https://doaj.org/article/51223a4fadff458db042a84805083d53
Autor:
Auyon J. Ghosh, Brian D. Hobbs, Jeong H. Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P. Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise, Fernando J. Martinez, Daniel McGoldrick, Michael H. Cho, Dawn L. DeMeo, Edwin K. Silverman, Peter J. Castaldi, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Craig P. Hersh
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These features have not been wel
Externí odkaz:
https://doaj.org/article/ded6f4fb9d3741b1812f3299d3b1e25c
Autor:
Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan, Craig P. Hersh, the COPDGene Investigators
Publikováno v:
BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D
Externí odkaz:
https://doaj.org/article/aa4abaa66f2c4839ad162342221a690e
Autor:
Jewel Imani, Kaifeng Liu, Ye Cui, Jean-Pierre Assaker, Junwen Han, Auyon J. Ghosh, Julie Ng, Shikshya Shrestha, Anthony M. Lamattina, Pierce H. Louis, Anne Hentschel, Anthony J. Esposito, Ivan O. Rosas, Xiaoli Liu, Mark A. Perrella, Jamil Azzi, Gary Visner, Souheil El-Chemaly
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Lung allograft rejection results in the accumulation of low–molecular weight hyaluronic acid (LMW-HA), which further propagates inflammation and tissue injury. We have previously shown that therapeutic lymphangiogenesis in a murine model of lung al
Externí odkaz:
https://doaj.org/article/3872cafd531f498db289be7c44439e4d
Autor:
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Externí odkaz:
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
Autor:
Harry Ramcharran, Jason H. T. Bates, Joshua Satalin, Sarah Blair, Penny L. Andrews, Donald P. Gaver, Louis A. Gatto, Guirong Wang, Auyon J. Ghosh, Benjamin Robedee, James Vossler, Nader M. Habashi, Nirav Daphtary, Michaela Kollisch-Singule, Gary F. Nieman
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 133(5)
Ventilator-induced lung injury (VILI) is a significant risk for patients with acute respiratory distress syndrome (ARDS). Management of the patient with ARDS is currently dominated by the use of low tidal volume mechanical ventilation, the presumptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05348faf8cd5f172930d16585e937824
https://pubmed.ncbi.nlm.nih.gov/36135956
https://pubmed.ncbi.nlm.nih.gov/36135956
Autor:
Matthew Moll, Sharon M. Lutz, Auyon J. Ghosh, Phuwanat Sakornsakolpat, Craig P. Hersh, Terri H. Beaty, Frank Dudbridge, Martin D. Tobin, Murray A. Mittleman, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Publikováno v:
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
Introduction Family history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (Polygenic Risk Score, PRS). Whether the PRS and family history provide compleme
Externí odkaz:
https://doaj.org/article/97ef5f120575410ba14b9fa725e334df
Autor:
Akinori Hata, Aravind A. Menon, Jason L. Sanders, Gary M. Hunninghake, George R. Washko, Samuel Y. Ash, Rachel K. Putman, Takuya Hino, Auyon J. Ghosh, David A. Lynch, Hiroto Hatabu, Ivan O. Rosas, Edwin K. Silverman, Michael H. Cho, Mizuki Nishino
Publikováno v:
Chest. 161:999-1010
Most pulmonary conditions reduce FVC, but studies of patients with combined pulmonary fibrosis and emphysema demonstrate that reductions in FVC are less than expected when these two conditions coexist clinically.Do interstitial lung abnormalities (IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ed4115db1d2149a4bd2b2b242afb61
https://doi.org/10.1016/j.chest.2021.10.034
https://doi.org/10.1016/j.chest.2021.10.034