Zobrazeno 1 - 10
of 376
pro vyhledávání: '"Autophagy-lysosome"'
Autor:
Ranran Zhang, Xiaoyan Huang, Chunling Zhou, Qian Zhang, Dongsheng Jia, Xiaoliang Xie, Ju Zhang
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of Menispermum dauricum DC, exhibits promising anti-Alzheimer’s disease (AD) effects, but its underlying mechanisms remain inadequately investigate
Externí odkaz:
https://doaj.org/article/f71749cdbe3644e28b73c103cba9f1ea
Autor:
Arun Kumar, Manti Kumar Saha, Vipin Kumar, Anupam Bhattacharya, Sagar Barge, Ashis K. Mukherjee, Mohan C. Kalita, Mojibur R. Khan
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-26 (2024)
Abstract Background Proteostasis is a critical aging hallmark responsible for removing damaged or misfolded proteins and their aggregates by improving proteasomal degradation through the autophagy-lysosome pathway (ALP) and the ubiquitin–proteasome
Externí odkaz:
https://doaj.org/article/aa0932f2118e495c882362803d5f1708
Autor:
Qinghu Yang, Chengxiang Yan, Yahan Sun, Zhen Xie, Liang Yang, Ming Jiang, Junjun Ni, Beining Chen, Sen Xu, Zhaoyue Yuan, Yanyan Wu, Xia Liu, Zengqiang Yuan, Zhantao Bai
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer's disease (AD) risk; however, the underlying mechanisms are not fully understood. Here, it is found that the injection of chondroitinase ABC (ChABC), mimicking ECM remodel
Externí odkaz:
https://doaj.org/article/bcfa97501e494d9699f74a4679329739
Autor:
Yixian Li, Peng Yang, Ran Meng, Shuting Xu, Lingling Zhou, Kang Qian, Pengzhen Wang, Yunlong Cheng, Dongyu Sheng, Minjun Xu, Tianying Wang, Jing Wu, Jinxu Cao, Qizhi Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1380-1399 (2024)
Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer's disease (AD) collectively culminate in neuronal deterioration. In the context of AD, autophagy dysfunction, a multi-link obstacle involving autophagy down
Externí odkaz:
https://doaj.org/article/8bd04ee938174169b40471e454fdf68d
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 39, Iss 12, Pp 1200-1212 (2023)
Abstract Dysregulated maturation and activation of dendritic cells (DCs) play a significant role in the progression of systemic lupus erythematosus (SLE). The autophagy–lysosome pathway has been identified as a potential mechanism to inhibit DC act
Externí odkaz:
https://doaj.org/article/18a8b55c67f547c489c80e5c496a02e6
Autor:
Zhendong Xu, Jichang Hu, Zhen Wei, Yu Lei, Henok Kessete Afewerky, Yang Gao, Lu Wan, Longfei Li, Ling Lei, Yi Liu, Fang Huang, Tong Yu, Jian‐Zhi Wang, Hong‐Lian Li, Rong Liu, Xiaochuan Wang
Publikováno v:
MedComm, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract Senile plaque, composed of amyloid β protein (Aβ) aggregates, is a critical pathological feature in Alzheimer's disease (AD), leading to cognitive dysfunction. However, how Aβ aggregates exert age‐dependent toxicity and temporal cogniti
Externí odkaz:
https://doaj.org/article/62d0d1779abc4c23b5ba94d28a53baad
Autor:
He Sun, Miao Li, Yunling Li, Na Zheng, Jiaxin Li, Xiang Li, Yingying Liu, Qianyun Ji, Liping Zhou, Jingwen Su, Wanxu Huang, Zhongbo Liu, Peng Liu, Libo Zou
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7709 (2024)
Gastrodin (GAS) is the main chemical component of the traditional Chinese herb Gastrodia elata (called “Tianma” in Chinese), which has been used to treat neurological conditions, including headaches, epilepsy, stroke, and memory loss. To our know
Externí odkaz:
https://doaj.org/article/5c6e1a850ae744a48024f10a675a78a2
Autor:
Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-21 (2023)
Abstract Background There are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggreg
Externí odkaz:
https://doaj.org/article/63f416f66800494bb59e84f43141648f
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1150-1167 (2023)
Abstract Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the quality of life of cancer patients, decreases the efficiency of therapeutic strategies and ultimately contributes to decrease their lifespan. The depletion
Externí odkaz:
https://doaj.org/article/6d18acfa69684c46835f375c7225d4db