Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Autophagy-lysosomal pathway"'
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106568- (2024)
Substantial work has been devoted to better understand the contribution of the myriad of genes that may underly the development of Parkinson's disease (PD) and their role in disease etiology. The small GTPase Ras-like without CAAX2 (RIT2) is one such
Externí odkaz:
https://doaj.org/article/3adcfb657fbd42559f2904e87d26312a
Autor:
Moritz Meyer-Jens, Kristin Wenzel, Karina Grube, Julia Rüdebusch, Elisabeth Krämer, Martin Bahls, Kilian Müller, Hannah Voß, Hartmut Schlüter, Stephan B. Felix, Lucie Carrier, Stephanie Könemann, Saskia Schlossarek
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 7, Iss , Pp 100059- (2024)
Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor–neprilysin inhibitors and has been used for the treatment of heart failure (HF) for several years. The mechanisms that mediate the beneficial effects of Sac/Val are not yet
Externí odkaz:
https://doaj.org/article/d2ef4d241de746f5a3ef0a5e68bc9de6
Autor:
Abdul Alim Al-Bari
Publikováno v:
All Life, Vol 15, Iss 1, Pp 568-601 (2022)
Autophagy process coordinates lysosomal destruction of cytoplasmic materials including damaged organelles and proteins. The double-membranous ‘autophagosome’ selectively sequesters the cytosolic components, followed by ‘autolysosome’ formatio
Externí odkaz:
https://doaj.org/article/0601bf7aa58144d389d28681125f01c0
Akademický článek
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Akademický článek
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Autor:
Hao Yu, Minghe Fan, Xiying Chen, Xiuhuan Jiang, Juan J. Loor, Ahmad Aboragah, Cai Zhang, Hongxu Bai, Zhiyuan Fang, Taiyu Shen, Zhe Wang, Yuxiang Song, Xinwei Li, Guowen Liu, Xiaobing Li, Xiliang Du
Publikováno v:
Journal of Dairy Science, Vol 105, Iss 8, Pp 6997-7010 (2022)
ABSTRACT: Activated autophagy-lysosomal pathway (ALP) can degrade virtually all kinds of cellular components, including intracellular lipid droplets, especially during catabolic conditions. Sustained lipolysis and increased plasma fatty acids concent
Externí odkaz:
https://doaj.org/article/28de0d8ad64b49579b82beb0d899bd83
Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/626dc3b840e843139dd95c32d25a00f6
Autor:
Fahad Mubariz, Afsoon Saadin, Nicholas Lingenfelter, Chinmoy Sarkar, Aditi Banerjee, Marta M. Lipinski, Ola Awad
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson’s disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the defective lysosomal clearance of autophagic substrates and aggregate-p
Externí odkaz:
https://doaj.org/article/0f914e2d22a64207b8445354ba5f321e
Autor:
Junsheng Yang, Chaoyue Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The autophagy-lysosomal pathway (ALP) is the major biological pathway responsible for clearing intracellular protein aggregates, therefore a promising target for treating diseases featuring the accumulation of aggregation-prone proteins, such as Hunt
Externí odkaz:
https://doaj.org/article/9bd076d04b9c4d0ab43b09bb0a71aa26
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-26 (2022)
Abstract Living organisms constantly need to adapt to their surrounding environment and have evolved sophisticated mechanisms to deal with stress. Mitochondria and lysosomes are central organelles in the response to energy and nutrient availability w
Externí odkaz:
https://doaj.org/article/c80740e5d0984065af7db6e09eb47634