Zobrazeno 1 - 10
of 541
pro vyhledávání: '"Autophagy inhibition"'
Autor:
Jie Gao, Yonghua Zhai, Weihong Lu, Xianghe Jiang, Jingsheng Zhou, Lili Wu, Longhai Du, Chunqing Ou, Xinyi Zhang, Hanliang He, Jian Zhu, Zhengbiao Zhang, Meiyun Li, Yan Wu, Xiangqiang Pan
Publikováno v:
Bioactive Materials, Vol 41, Iss , Pp 597-610 (2024)
In the field of cancer therapy, inhibiting autophagy has emerged as a promising strategy. However, pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1 (PD-L1), enabling tumor immune evasion. To address th
Externí odkaz:
https://doaj.org/article/0132123d6b9148a8a2f00a01aa7fa5b6
Autor:
Yaoben Wang, Xiaobin Chen, Zhiyong Chen, Xin Wang, Hancheng Wang, Huajuan Zhai, Jiandong Ding, Lin Yu
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 336-353 (2024)
While mild hyperthermia holds great potential in the treatment of solid tumors, the thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed of the
Externí odkaz:
https://doaj.org/article/7b03dc1b52b14e38b358f74f08ce42fa
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear. In this study, we focused on its ability to inhibit triple-negative breast ca
Externí odkaz:
https://doaj.org/article/8445f70694ce4bf2905658613fb93402
Autor:
Weina Guo, Haifeng Zhou, Jingbo Wang, Junjie Lu, Yalan Dong, Zhenyu Kang, Xiaoyuan Qiu, Xiaohu Ouyang, Qianyun Chen, Junyi Li, Xiang Cheng, Keye Du, Mingyue Li, Zhihao Lin, Min Jin, Lei Zhang, Alexey Sarapultsev, Kuangyu Shi, Fangfei Li, Ge Zhang, Kongming Wu, Yueguang Rong, Vigo Heissmeyer, Yue Liu, Yunlun Li, Kun Huang, Shanshan Luo, Desheng Hu
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Aloperine (ALO), a quinolizidine‐type alkaloid isolated from a natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive. Here, it is demonstrated that ALO
Externí odkaz:
https://doaj.org/article/ae4118359ede4834ae5c0ac482316ba0
Autor:
Qiugu Chen, Yuan Liao, Yujiao Liu, Yue Song, Junbo Jiang, Zhen zhang, Anqi Li, Mengyi zheng, Xiaoyi Chen, Tingxiu Zhao, Jiangyong Gu, Yuhui Tan, Xiaoyi Liu, Yanjun Jiang, Kun Wang, Hua Yi, Jianyong Xiao, Shan Hu
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Background Clinically, although chemotherapy is one of the most commonly used methods of treating tumors, chemotherapeutic drugs can induce autophagic flux and increase tumor cell resistance, leading to drug tolerance. Therefore, theoretical
Externí odkaz:
https://doaj.org/article/854968aae8cc4dbdbef57391ccb2c1a5
Autor:
Yingying Mo, Ganfeng Li, Qixing Tan, Zhiru Jin, Bin Deng, Ping Fan, Lianghao Huang, Jian Liao, Qingyan Wang, Xing Chen, Ji Wu, Gang Huang
Publikováno v:
Materials & Design, Vol 236, Iss , Pp 112511- (2023)
Inspired by the fact that therapeutic efficacy for triple negative breast cancer (TNBC) is weaken due to the enhancement of autophagy levels after long-term use of chemotherapeutic agents, a theranostic nanoplatform (CQ@ICG@PFH@PDA-PEG5k) integrating
Externí odkaz:
https://doaj.org/article/5aed6191792442f1a5bdf652b3d51609
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 1781-1789 (2022)
Context Polyphyllin II (PPII) is a steroidal saponin isolated from Rhizoma Paridis. It exhibits significant antitumor activity such as anti-proliferation and pro-apoptosis in lung cancer.Objective To explore whether PPII induce autophagy and the rela
Externí odkaz:
https://doaj.org/article/a4497c4bc8824b799a47888eedf23a9b
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