Výsledky vyhledávání - "Autophagosome maturation"

Akademický článek

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

Autor: Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes

Publikováno v: FASEB BioAdvances, Vol 1, Iss 11, Pp 688-705 (2019)

Abstract Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD

Externí odkaz: https://doaj.org/article/cdb8ba9ea62e4c0dade8fba235ccd388

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Akademický článek

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Akademický článek

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Akademický článek

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UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma

Autor: Hongyu Ding, YongJie Xu, Ronggui Hu, Xiangyan Zhang, Hui Chen, Yingjie Nie, LiLing Gu, Runsang Pan, Yun Yang, Chuanyin Li, Fang Liu

Publikováno v: Molecular Oncology, Vol 15, Iss 12, Pp 3738-3752 (2021)
Molecular Oncology

ATM serine/threonine kinase (ATM; previously known as ataxia‐telangiectasia mutated) plays a critical role in maintaining genomic stability and regulates multiple downstream pathways, such as DNA repair, cell cycle arrest, and apoptosis. As a serin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19e2b11561c135e914cc7616bd3d023
https://doaj.org/article/c30d625dab974349afe266e11ed47685

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Akademický článek

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AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network

Autor: Piyali Majumder, Daisy Edmison, Catherine Rodger, Sruchi Patel, Evan Reid, Swetha Gowrishankar

The adaptor protein complex-4 or AP-4 is known to mediate autophagosome maturation through regulating sorting of transmembrane cargo such as ATG9A at the Golgi. There is a need to understand AP-4 function in neurons, as mutations in any of its four s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed348329a7516b6def0da700eb4d992b
https://www.repository.cam.ac.uk/handle/1810/340002

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Machinery, regulation and pathophysiological implications of autophagosome maturation

Autor: Patrice Codogno, Hong Zhang, Yan G Zhao

Publikováno v: Nature Reviews. Molecular Cell Biology

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby cytosolic materials are sequestered in a double-membrane autophagosome and subsequently delivered to lysosomes, where they are broken down. In multicellular orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48b33f6236481f210f67e031272f42f
https://doi.org/10.1038/s41580-021-00392-4

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Double-Transmembrane Domain of SNAREs Decelerates the Fusion by Increasing the Protein-Lipid Mismatch

Autor: Bing Bu, Zhiqi Tian, Dechang Li, Kai Zhang, Wei Chen, Baohua Ji, Jiajie Diao

Publikováno v: Journal of Molecular Biology. :168089

Membrane fusion mediated by Soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) proteins is an important cellular process. For neuronal SNAREs, the single transmembrane domain has been proposed to pass zippering energy to me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eb68934ed76996fb922aaac3eaa4dc
https://doi.org/10.1016/j.jmb.2023.168089

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Inhibition of p97/VCP function leads to defective autophagosome maturation, cell cycle arrest and apoptosis in mouse Sertoli cells

Autor: Sevil Cayli, Cansu Sahin, Hilal Nakkas, Tuba Ozdemir Sanci

Publikováno v: Theriogenology. 158:196-206

p97/valosin-containing protein (VCP) is expressed in many cells and plays critical functions in a broad range of diverse cellular processes. Because it is expressed in the mouse testes, predominantly in Sertoli cells, and is known to play a critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a7e2d7eeb1b7d9464151bbc270c83c
https://doi.org/10.1016/j.theriogenology.2020.09.017

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