Zobrazeno 1 - 10
of 1 804
pro vyhledávání: '"Autophagic flux"'
Autor:
Yang Wen, Xue Sun, Lingge Zeng, Shumei Liang, Deyu Li, Xiangtian Chen, Fanrui Zeng, Chao Zhang, Qiongyao Wang, Qinsong Zhong, Ling Deng, Linlang Guo
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Small cell lung cancer (SCLC) is characterized by rapid development of chemoresistance and poor outcomes. Cyclin‐dependent kinase 4/6 inhibitors (CDK4/6is) are widely used in breast cancer and other cancer types. However, the molecular mec
Externí odkaz:
https://doaj.org/article/98628396adf645e4bd067c93c6042796
Publikováno v:
PeerJ, Vol 12, p e18209 (2024)
Cardiovascular disease (CVD) remains the major cause of morbidity and mortality around the world. Transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and autophagy. Emerging studies revealed that TFEB also mediates cellular ad
Externí odkaz:
https://doaj.org/article/3a94ec9645e445e4972ce166daf969d2
Publikováno v:
Animal Nutrition, Vol 16, Iss , Pp 409-421 (2024)
Rotaviruses (RV) are a major cause of severe gastroenteritis, particularly in neonatal piglets. Despite the availability of effective vaccines, the development of antiviral therapies for RV remains an ongoing challenge. Retinoic acid (RA), a metaboli
Externí odkaz:
https://doaj.org/article/daf25a72c9514e03b82467f2211d6824
Autor:
Xueya Yao, Yingxiang Liu, Yongheng Sui, Miao Zheng, Ling Zhu, Quanfu Li, Michael Garnet Irwin, Liqun Yang, Qionghui Zhan, Jie Xiao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117038- (2024)
Introduction: Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist, is widely used for sedation and anesthesia in patients undergoing hepatectomy. However, the effect of DEX on autophagic flux and liver regeneration remains uncle
Externí odkaz:
https://doaj.org/article/491175ef92fb4474907ea269bcdc5c9d
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116819- (2024)
Background and purpose: Our previous research discovered that cinnamamide derivatives are a new type of potential cardioprotective agents myocardial ischemia-reperfusion (MIR) injury, among which Compound 10 exhibits wonderful beneficial action in vi
Externí odkaz:
https://doaj.org/article/3cdb3b5796a84d4e88e478e9dfaa3f9d
Autor:
Lamya Alsadhan, Yasser A. Elnakady, Badr A. Aldahmash, Aisha Alqarni, Layali M. Almutairi, Mansour I. Almansour, Ahmed Rady
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 6, Pp 103235- (2024)
Cancer continues to be a prominent global threat, and current chemotherapy options often involve tubulin-targeting compounds disrupting microtubule function. Autophagy's role in cancer varies across cell types, tumor stages, and carcinogenic stimuli.
Externí odkaz:
https://doaj.org/article/8efb56013915453aa2f1ea467b5a00a6
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101705- (2024)
(Macro)autophagy is a cellular degradation system for unnecessary materials, such as aggregate-prone TDP-43, a central molecule in neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Abemaciclib (
Externí odkaz:
https://doaj.org/article/6e41ffab52e64792978198969ecabe96
Autor:
Changhai Chen, Wen Ou, Chaobo Yang, Haiqiong Liu, Tao Yang, Huaqiang Mo, Weizhe Lu, Jing Yan, Aihua Chen
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33371- (2024)
Queen bee acid (QBA), which is exclusively found in royal jelly, has anti-inflammatory, antihypercholesterolemic, and antiangiogenic effects. A recent study demonstrated that QBA enhances autophagic flux in the heart. Considering the significant role
Externí odkaz:
https://doaj.org/article/89cb2e182e894ce4973efd0811d9901f
Autor:
María Paz Hernández-Cáceres, Daniela Pinto-Nuñez, Patricia Rivera, Paulina Burgos, Francisco Díaz-Castro, Alfredo Criollo, Maria Jose Yañez, Eugenia Morselli
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 2, Pp 264-271 (2024)
The brain is, after the adipose tissue, the organ with the greatest amount of lipids and diversity in their composition in the human body. In neurons, lipids are involved in signaling pathways controlling autophagy, a lysosome-dependent catabolic pro
Externí odkaz:
https://doaj.org/article/e1663c66758146ab8112d833c18a8d55
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27571- (2024)
The role of fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) demethylase, in non-small cell lung cancer (NSCLC) has recently received widespread attention. However the underlying mechanisms of FTO-mediated autophagy regulati
Externí odkaz:
https://doaj.org/article/5e5597590dcb4a96af3bd93e368f3361