Zobrazeno 1 - 10
of 1 517
pro vyhledávání: '"Autoimmune uveitis"'
Autor:
Kristin Hösel, Büsra Chasan, Jan Tode, Stefan Rose-John, Johann Baptist Roider, Christoph Ehlken
Publikováno v:
Journal of Ophthalmic Inflammation and Infection, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Purpose The aim of this study was to assess the functional and clinical impact of intravitreal administration of a neutralizing anti-IL-6 antibody in the treatment of experimental autoimmune uveitis (EAU) in mice. Methods EAU was induced in
Externí odkaz:
https://doaj.org/article/ab15c184b47b45a2943cd1cf13fb8556
Autor:
Zhao Fan, Yu Jing-Sheng
Publikováno v:
Open Life Sciences, Vol 19, Iss 1, Pp 168-77 (2024)
Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immune responses. They are widely distributed in various tissues and organs, including the eyes. In the ocular context, permanent DCs are present at the peripheral edge of the
Externí odkaz:
https://doaj.org/article/a4117fa856df4e39a455557a6344e89f
Autor:
Yaning Liu, Wanyun Zhang, Hongmiao Wang, Hui Liu, Qiuyue Yu, Xiang Luo, Xiaojie Feng, Peizeng Yang
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 284, Iss , Pp 116979- (2024)
The effect of fine particulate matter (PM2.5) on the development of uveitis remains unclear. Therefore, this study was designed to investigate the role of PM2.5 in experimental autoimmune uveitis (EAU) and its potential mechanism. Our results showed
Externí odkaz:
https://doaj.org/article/211afb168dd84942bfc93877ab1e8484
Autor:
Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang, Fanying Jiang, Yanan Guo, Mengqing Xiang
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-24 (2024)
Abstract Autoimmune uveitis is a leading cause of severe vision loss, and animal models provide unique opportunities for studying its pathogenesis and therapeutic strategies. Here we employ scRNA-seq, RNA-seq and various molecular and cellular approa
Externí odkaz:
https://doaj.org/article/47a9b7f43a8c447a876177cb900f6df3
Autor:
Yanan Duan, Xiteng Chen, Hui Shao, Yongtao Li, Zhihui Zhang, Huan Li, Chuan Zhao, Hong Xiao, Jiawei Wang, Xiaomin Zhang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Autoimmune uveitis is an inflammatory disease triggered by an aberrant immune response. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) are emerging as potential therapeutic agents for this condition. CD73, a
Externí odkaz:
https://doaj.org/article/08962d62a53048b3be50f9a569f15383
Autor:
Lei Zhu, He Li, Xuening Peng, Zhaohuai Li, Sichen Zhao, Dongting Wu, Jialing Chen, Si Li, Renbing Jia, Zuohong Li, Wenru Su
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background Dimethyl fumarate (DMF) is a fumaric acid ester that exhibits immunoregulatory and anti-inflammatory properties. However, the function of DMF in autoimmune uveitis (AU) is incompletely understood, and studies comprehensively explo
Externí odkaz:
https://doaj.org/article/c4a853a943bd40e4ae00bd3bd099c166
Autor:
Dirk Bauer, Michael R. R. Böhm, Xiaoyu Wu, Bo Wang, Tida Viola Jalilvand, Martin Busch, Maren Kasper, Katrin Brockhaus, Lena Wildschütz, Harutyun Melkonyan, Björn Laffer, Gerd Meyer Zu Hörste, Arnd Heiligenhaus, Solon Thanos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Crystallin βb2 (crybb2) is upregulated in regenerating retinas and in various pathological conditions of the retina, including uveoretinitis. However, the role of crybb2 in this disease is largely unknown. Therefore, we used recombinant crybb2 (rcry
Externí odkaz:
https://doaj.org/article/7e030ac7725d478789e7cd37ea90ca85
Autor:
Jiaxing Huang, Xiaotang Wang, Na Li, Wei Fan, Xingran Li, Qian Zhou, Jiangyi Liu, Wanqian Li, Zhi Zhang, Xiaoyan Liu, Shuhao Zeng, Hui Yang, Meng Tian, Peizeng Yang, Shengping Hou
Publikováno v:
Advanced Science, Vol 11, Iss 19, Pp n/a-n/a (2024)
Abstract Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases. Here, an increased
Externí odkaz:
https://doaj.org/article/702f5448020c483a8db4100423ee997d
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis
Autor:
Jiangyi Liu, Xingyun Liao, Na Li, Zongren Xu, Wang Yang, Hongxiu Zhou, Yusen Liu, Zhi Zhang, Guoqing Wang, Shengping Hou
Publikováno v:
MedComm, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract Autoimmune uveitis (AU) is a kind of immune‐mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and pr
Externí odkaz:
https://doaj.org/article/950c88ce32a247dba87b0802384468f3
Publikováno v:
International Journal of Nanomedicine, Vol Volume 18, Pp 4347-4363 (2023)
Chang Huang,1,2,* Zhutian Zhang,1,2,* Jifeng Gu,3,* Dan Li,1,2 Shunxiang Gao,1,2 Rong Zhang,1,2 Rong Shi,4 Jianguo Sun1,2 1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shan
Externí odkaz:
https://doaj.org/article/e96e4d50179c46b38a874f21038ac931